DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cag and TIGD2

DIOPT Version :9

Sequence 1:	NP_001260876.1	Gene:	cag / 36157	FlyBaseID:	FBgn0017414	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	NP_001369309.1	Gene:	TIGD2 / 166815	HGNCID:	18333	Length:	525	Species:	Homo sapiens

Alignment Length:	137	Identity:	42/137 - (30%)
Similarity:	78/137 - (56%)	Gaps:	11/137 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RKPRTSLTLEEKMEVIQSQERNKLSVRDLAKRFNIGKTQAADILKHKQSI-----KEGLLSGELK 66
            ::.|..||:::|:::|:..|.. :|.:.|:..:.||::...||.|:|:.|     .....||..|
Human     4 KRKRVVLTIKDKLDIIKKLEEG-ISFKKLSVVYGIGESTVRDIKKNKERIINYANSSDPTSGVSK 67

  Fly    67 LNQMRRNPLSQRGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELG-HSNFSASSGWLEK 130
            ...|:    |....::|.:..:||::.:|:.||:||.:..|:||.....|| ..:|:||||||.:
Human    68 RKSMK----SSTYEELDRVMIEWFNQQKTDGIPVSGTICAKQAKFFFDALGMEGDFNASSGWLTR 128

  Fly   131 WRKRHNV 137
            :::||.:
Human   129 FKQRHGI 135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cag	NP_001260876.1	CENP-B_N	7..60	CDD:282122	15/57 (26%)
cag	NP_001260876.1	CENPB	78..141	CDD:197828	22/61 (36%)
TIGD2	NP_001369309.1	HTH	4..52	CDD:419669	14/48 (29%)
		HTH_Tnp_Tc5	76..135	CDD:397365	22/58 (38%)
		DDE_1	207..385	CDD:367380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343623at2759
OrthoFinder	1	1.000	-	-		FOG0000365
OrthoInspector	1	1.000	-	-		otm40429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820