DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and ZNF160

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	1239	Identity:	219/1239 - (17%)
Similarity:	348/1239 - (28%)	Gaps:	534/1239 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 QEKPACAEPVQPLKTMRHECQVCGVVLYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFEHY 187
            ||:..|.:|.|.             :||..:.|:.:....:.|      ||.|..        :.
Human    19 QEEWKCLDPAQR-------------ILYRDVMLENYWNLVSLG------LCHFDM--------NI 56

  Fly   188 VTMHNMPLSQAEE--YVKS--KHLPAPKEEE-VKAV-------CTLEDM--------ELLIPTVL 232
            ::|    |.:.:|  .|||  |....|:..| ||.|       ||::|:        |.:..||:
Human    57 ISM----LEEGKEPWTVKSCVKIARKPRTPECVKGVVTDIPPKCTIKDLLPKEKSSTEAVFHTVV 117

  Fly   233 -----RPE----DYVQPHPHI--------------------------DNDQLRDID-----HQLA 257
                 .|:    .:.:|..::                          |....|||:     :||.
Human   118 LERHESPDIEDFSFKEPQKNVHDFECQWRDDTGNYKGVLMAQKEGKRDQRDRRDIENKLMNNQLG 182

  Fly   258 VSMDEPVPSVDSLTSTLPPMDTPNVSIGTEYLVLPDGSLQQVNGSGVVIE--YIDDSKPNSSSNV 320
            ||....:|                             .||...|.|.:.|  .::.|..|.||
Human   183 VSFHSHLP-----------------------------ELQLFQGEGKMYECNQVEKSTNNGSS-- 216

  Fly   321 NVS-LQNLLSS---HNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVAR 381
             || ||.:.||   |......::|...:.....:.....||         :||..|.|.|:..:.
Human   217 -VSPLQQIPSSVQTHRSKKYHELNHFSLLTQRRKANSCGKP---------YKCNECGKAFTQNSN 271

  Fly   382 LKSHQLTHSNLPKFFCDQC-DFYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMC 445
            |.||:..||....:.|.:| ..:::||       .:..|:|...|:           :.|.|..|
Human   272 LTSHRRIHSGEKPYKCSECGKTFTVRS-------NLTIHQVIHTGE-----------KPYKCHEC 318

  Fly   446 --LFETSTVSQLRTHYKERHTVQPTEVQLRPSWTGE-PTTTRGVAAKQQTPAKILNHTDIPLGIK 507
              :|..:  |.|.||              |...||| |..........:..:.:..|..|..|.|
Human   319 GKVFRHN--SYLATH--------------RRIHTGEKPYKCNECGKAFRGHSNLTTHQLIHTGEK 367

  Fly   508 YPPGVLETQAPLPQPVVHQPMPDPMQQTEPMATTSTTITESGDINVVVDATPLFYAATSNSLLVT 572
                                   |.:..|                    ...||   |.||.|::
Human   368 -----------------------PFKCNE--------------------CGKLF---TQNSHLIS 386

  Fly   573 NPAPVTTVEETTGTASNHAFGIFPEISEGNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAI 637
            :....|..:.........||.:     ..:|.:::.:.
Human   387 HWRIHTGEKPYKCNECGKAFSV-----RSSLAIHQTIH--------------------------- 419

  Fly   638 CTIPADGMPVVDGDDIVIDNNNISLDFDAENLFEDFEEEEDDTVADEEDEADNEDENDNNDAATD 702
                                                                           |.
Human   420 ---------------------------------------------------------------TG 421

  Fly   703 QNLLLTSDDDDVDDFDDEQSKHL-----QKPY-CIYCNKKFTSQYKFENHMFVHRGLAPYRCELC 761
            :.....::...|..::....:|.     :||| |..|.|.|:.......|..:|.|..|::|..|
Human   422 EKPYKCNECGKVFRYNSYLGRHRRVHTGEKPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNEC 486

  Fly   762 TNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECES 826
            :.::.....|..|.:......|.:.....|...|..:.|..:.::.|  :.|.    || .||..
Human   487 SKVFTQNSQLANHRRIHTGEKPYKCNECGKAFSVRSSLTTHQAIHSG--EKPY----KC-IECGK 544

  Fly   827 DSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQ 891
            ....:.||.:|.||:.|            :.|::|..|.:.||..:.|:||.:
Human   545 SFTQKSHLRSHRGIHSG------------EKPYKCNECGKVFAQTSQLARHWR------------ 585

  Fly   892 TPHCGEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTG 956
             .|.||
Human   586 -VHTGE----------------------------------------------------------- 590

  Fly   957 VKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFD 1021
                                                                         .|:
Human   591 -------------------------------------------------------------KPY- 593

  Fly  1022 FDYDIMRDEAQQSSPNIHDVSKALSDNASSSCPINESYKLLSTTALET--SPAKGLRSNSRLHRS 1084
                           ..:|..:|.||.:|          |....|:.|  .|.|
Human   594 ---------------KCNDCGRAFSDRSS----------LTFHQAIHTGEKPYK----------- 622

  Fly  1085 SIHICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKS 1149
                |..|.:.|.....|..|. .:|:..:      .:||..|..::...:.|..|...|:..|.
Human   623 ----CHECGKVFRHNSYLATHR-RIHTGEK------PYKCNECGKAFSMHSNLTTHKVIHTGEKP 676

  Fly  1150 -QCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTR-YICPV 1212
             :|..|.|.|...:.|..|.:. |:.:|..||  :.|.|.|:.:..|..|| |.|...: |.|..
Human   677 YKCNQCGKVFTQNSHLANHQRT-HTGEKPYRC--NECGKAFSVRSSLTTHQ-AIHTGKKPYKCNE 737

  Fly  1213 CNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHALIIH--DLRFTTEELGNLSSLA 1275
            |.|....|.||.||..:|.||..|:|.:|.:::..|..|.|| :.||  :.|:...|.|.:...:
Human   738 CGKVFTQNAHLANHRRIHTGEKPYRCTECGKAFRVRSSLTTH-MAIHTGEKRYKCNECGKVFRQS 801

  Fly  1276 TNQA 1279
            :|.|
Human   802 SNLA 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..418	CDD:275368	4/21 (19%)
		C2H2 Zn finger	442..460	CDD:275368	7/19 (37%)
		C2H2 Zn finger	730..750	CDD:275368	5/19 (26%)
		C2H2 Zn finger	758..777	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1089..1110	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1124..1144	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1210..1230	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1238..1254	CDD:275368	4/15 (27%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630	15/79 (19%)
		KRAB	8..47	CDD:279668	8/40 (20%)
		zf-C2H2	257..279	CDD:278523	8/21 (38%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	271..295	CDD:290200	7/23 (30%)
		C2H2 Zn finger	287..307	CDD:275368	6/26 (23%)
		zf-H2C2_2	299..324	CDD:290200	7/35 (20%)
		C2H2 Zn finger	315..335	CDD:275368	8/35 (23%)
		zf-H2C2_2	327..350	CDD:290200	8/36 (22%)
		C2H2 Zn finger	343..363	CDD:275368	1/19 (5%)
		zf-H2C2_2	355..380	CDD:290200	8/70 (11%)
		COG5048	367..810	CDD:227381	126/785 (16%)
		C2H2 Zn finger	371..391	CDD:275368	7/42 (17%)
		C2H2 Zn finger	399..419	CDD:275368	3/24 (13%)
		zf-H2C2_2	411..436	CDD:290200	3/114 (3%)
		C2H2 Zn finger	427..447	CDD:275368	2/19 (11%)
		zf-H2C2_2	439..463	CDD:290200	7/23 (30%)
		C2H2 Zn finger	455..475	CDD:275368	5/19 (26%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		zf-H2C2_2	496..519	CDD:290200	4/22 (18%)
		C2H2 Zn finger	511..531	CDD:275368	3/19 (16%)
		zf-H2C2_2	523..548	CDD:290200	7/31 (23%)
		C2H2 Zn finger	539..559	CDD:275368	7/20 (35%)
		zf-H2C2_2	551..576	CDD:290200	10/36 (28%)
		C2H2 Zn finger	567..587	CDD:275368	7/32 (22%)
		C2H2 Zn finger	595..615	CDD:275368	7/29 (24%)
		zf-H2C2_2	607..632	CDD:290200	9/49 (18%)
		C2H2 Zn finger	623..643	CDD:275368	5/20 (25%)
		zf-H2C2_2	635..659	CDD:290200	6/30 (20%)
		C2H2 Zn finger	651..671	CDD:275368	4/19 (21%)
		zf-H2C2_2	663..688	CDD:290200	8/24 (33%)
		C2H2 Zn finger	679..699	CDD:275368	6/20 (30%)
		zf-H2C2_2	691..715	CDD:290200	8/26 (31%)
		C2H2 Zn finger	707..727	CDD:275368	8/22 (36%)
		zf-H2C2_2	719..744	CDD:290200	9/25 (36%)
		C2H2 Zn finger	735..755	CDD:275368	8/19 (42%)
		zf-H2C2_2	747..770	CDD:290200	10/22 (45%)
		C2H2 Zn finger	763..783	CDD:275368	6/20 (30%)
		zf-H2C2_2	775..800	CDD:290200	8/25 (32%)
		C2H2 Zn finger	791..811	CDD:275368	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930