DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and ZNF347

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	1199	Identity:	216/1199 - (18%)
Similarity:	335/1199 - (27%)	Gaps:	542/1199 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 LKTMRHECQVCGVVLYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFEHYVTMHNMPLSQAE 199
            :|.:.|:.:.....::..:.|::...|..||       |||..:::.|        |.:
Human    99 MKDLLHKGKSNTGEVFQTVMLERQESQDIEG-------CSFREVQKNT--------HGL------ 142

  Fly   200 EYVKSKHLPAPKEEEVKAVCTLEDMELLIPTVLRPEDYVQPHPHIDNDQLRD-----IDHQLAVS 259
            ||                  ...|.|.....||..::....|...::|: ||     |.:||.:|
Human   143 EY------------------QCRDAEGNYKGVLLTQEGNLTHGRDEHDK-RDARNKLIKNQLGLS 188

  Fly   260 MDEPVP-------------------SVDSLTSTLPPMDTP-NVS--IGTEY-------LVLPD-- 293
            :...:|                   |.::.:|..||...| ||.  |..:|       |:|..
Human   189 LQSHLPELQLFQYEGKIYECNQVEKSFNNNSSVSPPQQMPYNVKTHISKKYLKDFISSLLLTQGQ 253

  Fly   294 -----GSLQQVNGSGVVIEYIDDSKPNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRI 353
                 ||..:.||.|:|.       |.:|.         |:||.                 :...
Human   254 KANNWGSPYKSNGCGMVF-------PQNSH---------LASHQ-----------------RSHT 285

  Fly   354 KPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTHSNLPKFFCDQCDFYSLRSADLIQHYKMVH 418
            |.||         :||..|.|.|.|.:.|.:||:.|:...::.|::|.....|::.|.||.| :|
Human   286 KEKP---------YKCYECGKAFRTRSNLTTHQVIHTGEKRYKCNECGKVFSRNSQLSQHQK-IH 340

  Fly   419 HRVDENGKTGKEQAQGIESRVYSCDMCLFETSTVSQLRTHYKERHTVQPTEVQLRPSWTGEPTTT 483
                    ||:        :.|.|:.|    ..|....:|......:...|...:.:..|:....
Human   341 --------TGE--------KPYKCNEC----GKVFTQNSHLVRHRGIHTGEKPYKCNECGKAFRA 385

  Fly   484 RGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQPMPDPMQQTEPMATTSTTITES 548
            |...|                                   :||                  .|.|
Human   386 RSSLA-----------------------------------IHQ------------------ATHS 397

  Fly   549 GDINVVVDATPLFYAATSNSLLVTNPAPVTTVEET-TGTASNHAFGIFPEISEGNLPVNEAVQ-- 610
            |:.....:.....:  |.||.| ||...:.|.|:. .......|||:     ..:|.::..:.
Human   398 GEKPYKCNECGKVF--TQNSHL-TNHWRIHTGEKPYKCNECGKAFGV-----RSSLAIHLVIHTG 454

  Fly   611 QAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDA-ENLFEDFE 674
            :.|.......     :.|..|:.:|....|.....|        ...|.....|.| .||
Human   455 EKPYKCHECG-----KVFRRNSHLARHQLIHTGEKP--------YKCNECGKAFRAHSNL----- 501

  Fly   675 EEEDDTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPY-CIYCNKKFT 738
                                      |...::.|.                :||| |..|.|.||
Human   502 --------------------------TTHQVIHTG----------------EKPYKCNECGKVFT 524

  Fly   739 SQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIE 803
            ......||..:|.|:.||.|..|...:::...|..| :.:|..                     |
Human   525 QNSHLANHQRIHTGVKPYMCNECGKAFSVYSSLTTH-QVIHTG---------------------E 567

  Fly   804 KLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSF 868
            |.|            ||. ||........||..|.||:.|            :.|::|..|.:.|
Human   568 KPY------------KCN-ECGKVFTQNSHLARHRGIHTG------------EKPYKCNECGKVF 607

  Fly   869 AAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTDVGA 933
            ...:.|||| ||.|
Human   608 RHNSYLSRH-QRIH--------------------------------------------------- 620

  Fly   934 EKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATS 998
                                 ||.|
Human   621 ---------------------TGEK---------------------------------------- 624

  Fly   999 LESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKALSDNASSSCPINESYKLLS 1063
                                |:.:                ::..||.|::::
Human   625 --------------------PYKY----------------NEYGKAFSEHSN------------- 640

  Fly  1064 TTALETSPAKGLRSNSRLHRSSIHICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCAICN 1128
                                                  |..|:: :|:..:      .:||..|.
Human   641 --------------------------------------LTTHQV-IHTGEK------PYKCNECG 660

  Fly  1129 TSYRTLTLLKFHMKRHSNRKS-QCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDGCRKTFAFK 1192
            ..:...:.|..|.:.|:..|. ||..|.|:|...::|.||.:. |:.:|...|  :.|.|.|:.:
Human   661 KVFTQNSHLARHRRVHTGGKPYQCNECGKAFSQTSKLARHQRV-HTGEKPYEC--NQCGKAFSVR 722

  Fly  1193 HHLIRHQKASHLSTR-YICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHAL 1256
            ..|..|| |.|...: |.|..|.|....|.||..|..:|.||..|||.:|.:::.:..:|..|..
Human   723 SSLTTHQ-AIHTGKKPYKCNECGKVFTQNSHLARHRGIHTGEKPYKCNECGKAFSQTSKLARHQR 786

  Fly  1257 IIHDLRFTTE---ELGN----LSSLATNQ 1278
            |     .|.|   |.|.    .|||.|:|
Human   787 I-----HTGEKPYECGKPFSICSSLTTHQ 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..418	CDD:275368	7/20 (35%)
		C2H2 Zn finger	442..460	CDD:275368	4/17 (24%)
		C2H2 Zn finger	730..750	CDD:275368	7/19 (37%)
		C2H2 Zn finger	758..777	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1089..1110	CDD:275368	2/20 (10%)
		C2H2 Zn finger	1124..1144	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1151..1172	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1180..1203	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1210..1230	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1238..1254	CDD:275368	3/15 (20%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	265..284	CDD:275368	9/51 (18%)
		COG5048	273..728	CDD:227381	141/888 (16%)
		zf-H2C2_2	276..301	CDD:290200	11/59 (19%)
		C2H2 Zn finger	292..312	CDD:275368	8/19 (42%)
		zf-H2C2_2	304..329	CDD:290200	6/24 (25%)
		C2H2 Zn finger	320..340	CDD:275368	7/20 (35%)
		zf-H2C2_2	333..357	CDD:290200	11/44 (25%)
		C2H2 Zn finger	348..368	CDD:275368	4/23 (17%)
		zf-H2C2_2	360..383	CDD:290200	3/22 (14%)
		C2H2 Zn finger	376..396	CDD:275368	5/72 (7%)
		zf-H2C2_2	388..413	CDD:290200	6/79 (8%)
		C2H2 Zn finger	404..424	CDD:275368	6/22 (27%)
		zf-H2C2_2	416..439	CDD:290200	5/23 (22%)
		C2H2 Zn finger	432..452	CDD:275368	4/24 (17%)
		zf-H2C2_2	444..469	CDD:290200	3/29 (10%)
		zf-C2H2	458..480	CDD:278523	3/26 (12%)
		C2H2 Zn finger	460..480	CDD:275368	3/24 (13%)
		zf-H2C2_2	472..495	CDD:290200	4/30 (13%)
		C2H2 Zn finger	488..508	CDD:275368	6/50 (12%)
		zf-H2C2_2	500..525	CDD:290200	11/71 (15%)
		C2H2 Zn finger	516..536	CDD:275368	7/19 (37%)
		zf-H2C2_2	528..552	CDD:290200	8/23 (35%)
		C2H2 Zn finger	544..564	CDD:275368	4/20 (20%)
		zf-H2C2_2	556..581	CDD:290200	10/59 (17%)
		C2H2 Zn finger	572..592	CDD:275368	7/20 (35%)
		zf-H2C2_2	584..609	CDD:290200	10/36 (28%)
		C2H2 Zn finger	600..620	CDD:275368	9/20 (45%)
		C2H2 Zn finger	628..648	CDD:275368	5/87 (6%)
		zf-H2C2_2	640..665	CDD:290200	6/82 (7%)
		C2H2 Zn finger	656..676	CDD:275368	4/19 (21%)
		zf-H2C2_2	668..693	CDD:290200	9/24 (38%)
		C2H2 Zn finger	684..704	CDD:275368	7/20 (35%)
		zf-H2C2_2	697..720	CDD:290200	8/25 (32%)
		C2H2 Zn finger	712..732	CDD:275368	8/22 (36%)
		COG5048	723..>817	CDD:227381	32/94 (34%)
		zf-H2C2_2	724..749	CDD:290200	9/25 (36%)
		C2H2 Zn finger	740..760	CDD:275368	7/19 (37%)
		zf-H2C2_2	752..777	CDD:290200	10/24 (42%)
		C2H2 Zn finger	768..788	CDD:275368	5/24 (21%)
		C2H2 Zn finger	795..813	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930