DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and ZNF665

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	571	Identity:	109/571 - (19%)
Similarity:	188/571 - (32%)	Gaps:	174/571 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   726 QKPY-CIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQ 789
            :||| |..|.|.|.:..|...|..:|.|..||:|:.|...:.....|..|.:......|.:....
Human   287 EKPYKCNECGKAFRAHSKLTTHQVIHTGEKPYKCKECGKCFTQNSHLASHRRIHTGEKPYKCNEC 351

  Fly   790 AKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHG--------INDGVSE 846
            .|...|..:.|..:.::.|  :.| ..|.:|......:|.:.||...|.|        .....|.
Human   352 GKAFSVRSSLTTHQTIHTG--EKP-YKCNECGKVFRHNSYLAKHRRIHTGEKPYKCNECGKAFSM 413

  Fly   847 HAN----EVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSS 907
            |:|    ::....:.||:|..|::.|...:.|:.| :|.|..:.  ..:...||:|.:   ..||
Human   414 HSNLTKHQIIHTGEKPFKCNECVKVFTQYSHLANH-RRIHTGEK--PYRCDECGKAFS---VRSS 472

  Fly   908 STISEPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVT 972
            .|..:.::                                       ||.|
Human   473 LTTHQAIH---------------------------------------TGEK-------------- 484

  Fly   973 LDAATAVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPN 1037
                                                          |:                .
Human   485 ----------------------------------------------PY----------------K 487

  Fly  1038 IHDVSKALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHICKLCNQTFDELGKL 1102
            .:|..|..:.|:                  ..:..:|:.|..:.::     |..|.:.|.:..:|
Human   488 CNDCGKVFTQNS------------------HLASHRGIHSGEKPYK-----CDECGKAFSQTSQL 529

  Fly  1103 VKHEMELHSNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKS-QCKLCPKSFVTIAELER 1166
            .:| ..:|:..:      .:||..|..::...:.|..|...|:.:|. :|..|.|.|...:.|..
Human   530 ARH-WRVHTGEK------PYKCNECGKAFSVHSSLTIHQTIHTGQKPYKCNDCGKVFRHNSYLAI 587

  Fly  1167 HTKAKHSKDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHK 1231
            |.:. |:.:|..:|  :.|.|.|:...:|..||........|.|..|.|....|.||.||..:|.
Human   588 HQRI-HTGEKPYKC--NECGKAFSVHSNLATHQVIHTGEKPYKCNECGKVFTQNSHLANHRRIHT 649

  Fly  1232 GEITYKCPKCDRSYLRRGRLVTHALIIH--DLRFTTEELGNLSSLATNQAR 1280
            ||..|:|.:|.:::..|..|.|| :.:|  |..:...:.|.:.:..:|.|:
Human   650 GEKPYRCNECGKAFSVRSTLTTH-MAVHTGDKPYKCNQCGKVFTQNSNLAK 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368	6/19 (32%)
		C2H2 Zn finger	758..777	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1089..1110	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1124..1144	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1210..1230	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1238..1254	CDD:275368	4/15 (27%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	73/446 (16%)
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	348..368	CDD:275368	3/19 (16%)
		C2H2 Zn finger	376..396	CDD:275368	5/19 (26%)
		C2H2 Zn finger	404..424	CDD:275368	3/19 (16%)
		C2H2 Zn finger	432..452	CDD:275368	6/20 (30%)
		C2H2 Zn finger	460..480	CDD:275368	6/22 (27%)
		C2H2 Zn finger	488..508	CDD:275368	4/37 (11%)
		C2H2 Zn finger	516..536	CDD:275368	5/20 (25%)
		C2H2 Zn finger	544..564	CDD:275368	4/19 (21%)
		C2H2 Zn finger	572..592	CDD:275368	6/20 (30%)
		zf-H2C2_2	584..608	CDD:316026	7/26 (27%)
		C2H2 Zn finger	600..620	CDD:275368	7/21 (33%)
		zf-H2C2_2	612..637	CDD:316026	7/24 (29%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..664	CDD:316026	10/23 (43%)
		C2H2 Zn finger	656..676	CDD:275368	6/20 (30%)
		zf-H2C2_2	669..693	CDD:316026	6/24 (25%)
		C2H2 Zn finger	684..704	CDD:275368	3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930