DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and ZNF208

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	1292	Identity:	257/1292 - (19%)
Similarity:	420/1292 - (32%)	Gaps:	413/1292 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CLECSKSLQVAYYFLQNA-LRAHEIL-----------CRKLCPKVSKRLNGTLAQEQEKPACAEP 131
            |.||.|:      |.|:| |..|:|:           |.|...|||...........|||
Human   259 CEECGKA------FNQSAILTKHKIIHTGEKPNKCEECGKAFSKVSTLTTHKAIHAGEKP----- 312

  Fly   132 VQPLKTMRHECQVCGVVLYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFEHYVTMHNMPLS 196
                    ::|:.||........|..|...||....|.||.|.....|...|.:|.|........
Human   313 --------YKCKECGKAFSKVSTLITHKAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPY 369

  Fly   197 QAEE------------YVKSKHL---PAPKEEEVKAVCTLEDMELLIPTVLRPEDYV----QPHP 242
            :.||            |.|..|.   |...||..|.....        ::|...:.:    :|:.
Human   370 KCEECGKAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSMF--------SILTKHEVIHTGEKPYK 426

  Fly   243 HID-----NDQLRDIDHQLAVSMDEPVPSVD-----SLTSTLPPMDTPNVSIGTEYLVLPDG--- 294
            ..:     |.....::|:...:.:.|....:     |:.|.|           |::.|:.:|
Human   427 CEECGKAFNWSSNLMEHKKIHTGETPYKCEECGKGFSMFSIL-----------TKHKVIHNGEKP 480

  Fly   295 ----SLQQVNGSGVVIEYIDDSKP----------NSSSNVNVSLQNLLSSHNDPMDIDVNELIVE 345
                ...:...:|        .||          |.|||        |..|.
Human   481 YKCEECDKATHAG--------EKPYKCEECGKAFNWSSN--------LMEHK------------- 516

  Fly   346 EMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTHSNLPKFFCDQCDFYSLRSADL 410
                :|....||         :||:.|.|:|||.:.|..|::.|:....:.|::|. .:.:.:..
Human   517 ----RIHTGEKP---------YKCEECGKSFSTFSILTKHKVIHTGEKPYKCEECG-KAYKWSST 567

  Fly   411 IQHYKMVH-----HRVDENGKTGKEQAQGIE-------SRVYSCDMCLFETSTVSQLRTHYKERH 463
            :.::|.:|     ::.:|.||...:.|..|:       .:.|.|:.|....|.||.|.|| |..|
Human   568 LSYHKKIHTVEKPYKCEECGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFSKVSTLTTH-KAIH 631

  Fly   464 TVQPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQPM 528
            ..:      :|....|...| .:.....|..|.::..:.|...|
Human   632 AGE------KPYKCKECGKT-FIKVSTLTTHKAIHAGEKPYKCK--------------------- 668

  Fly   529 PDPMQQTEPMATTSTTITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGTASNHAFG 593
                              |.|      .|...|...|.:.::.|...|...  |..|.|.|.:..
Human   669 ------------------ECG------KAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNWSSN 707

  Fly   594 IF--PEISEGNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVID 656
            :.  ..|..|..|..  .::...:.|:.||.         |....|.|          |:.
Human   708 LMEHKRIHTGEKPYK--CEECGKSFSTFSVL---------TKHKVIHT----------GEK---- 747

  Fly   657 NNNISLDFDAENLFEDFE-------EEEDDTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDV 714
                  .:..|...:.::       .::..|| ::..:.:...:..|..|...::..:.:|
Human   748 ------PYKCEECGKAYKWSSTLSYHKKIHTV-EKPYKCEECGKAFNRSAILIKHKRIHTD---- 801

  Fly   715 DDFDDEQSKHLQKPY-CIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTV 778
                       :||| |..|.|.|:.......|..:|.|..||:|:.|...::...:|.|| |.:
Human   802 -----------EKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKECGKAFSKFSILTKH-KVI 854

  Fly   779 HK-RMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGIND 842
            |. ..|.:.....|..|.....:..:|::.|  :.|.    ||. ||.....|...|..|..|:.
Human   855 HTGEKPYKCEECGKAYKWPSTLSYHKKIHTG--EKPY----KCE-ECGKGFSMFSILTKHEVIHT 912

  Fly   843 GVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSS 907
            |            :.|::|..|.::|:..:..|:| :::|..:...:.:.  ||:|.     .||
Human   913 G------------EKPYKCEECGKAFSWLSVFSKH-KKTHAGEKFYKCEA--CGKAY-----KSS 957

  Fly   908 STISEPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGN-------------------EEGGTDD 953
            ||:|           :::.:.|:....|..|. |.|...                   ||.|...
Human   958 STLS-----------YHKKIHTEEKPYKYEEC-GKGFSTFSILTKHKVIHTGEKPYKCEECGKAF 1010

  Fly   954 G------------TGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESPVATT 1006
            .            ||   |.....||.|                     .|.:..:||....||.
Human  1011 NWSSNLMEHKKIHTG---ETPYKCEECD---------------------KAFSWPSSLTEHKATH 1051

  Fly  1007 ASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKA------LSDNASSSCPINESYKLLSTT 1065
            |...        |:                ...:..||      |:::.::... .|.||
Human  1052 AGEK--------PY----------------KCEECGKAFSWPSRLTEHKATHAG-EEPYK----- 1086

  Fly  1066 ALETSPAKGLRSNSRLHRSSIHI------CKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKC 1124
            ..|...|....||...|: .||.      |:.|.::|.....|.||:: :|:..:      .:||
Human  1087 CEECGKAFNWSSNLMEHK-RIHTGEKPYKCEECGKSFSTFSILTKHKV-IHTGEK------PYKC 1143

  Fly  1125 AICNTSYRTLTLLKFHMKRHSNRKS-QCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDGCRKT 1188
            ..|..:|:..:.|.:|.|.|:..|. :|:.|.|.||..:.|.:| |..|:.:|..:|  :.|.|.
Human  1144 EECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKGFVMFSILAKH-KVIHTGEKLYKC--EECGKA 1205

  Fly  1189 FAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSY 1245
            :.:...|..|:|.......|.|..|.|...:...|..|..:|.||..|||.:|.:::
Human  1206 YKWPSTLRYHKKIHTGEKPYKCEECGKAFSTFSILTKHKVIHTGEKPYKCEECGKAF 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	11/38 (29%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..418	CDD:275368	3/20 (15%)
		C2H2 Zn finger	442..460	CDD:275368	8/17 (47%)
		C2H2 Zn finger	730..750	CDD:275368	5/19 (26%)
		C2H2 Zn finger	758..777	CDD:275368	5/18 (28%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1151..1172	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1180..1203	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1210..1230	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1238..1254	CDD:275368	2/8 (25%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381	87/440 (20%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368	10/25 (40%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	4/19 (21%)
		zf-H2C2_2	384..407	CDD:290200	7/22 (32%)
		C2H2 Zn finger	399..419	CDD:275368	4/27 (15%)
		C2H2 Zn finger	427..447	CDD:275368	2/19 (11%)
		zf-H2C2_2	439..463	CDD:290200	2/23 (9%)
		C2H2 Zn finger	455..475	CDD:275368	5/30 (17%)
		C2H2 Zn finger	499..519	CDD:275368	6/44 (14%)
		zf-H2C2_2	511..536	CDD:290200	11/58 (19%)
		C2H2 Zn finger	527..547	CDD:275368	8/19 (42%)
		C2H2 Zn finger	555..575	CDD:275368	3/20 (15%)
		zf-H2C2_2	568..592	CDD:290200	5/23 (22%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	596..619	CDD:290200	4/22 (18%)
		C2H2 Zn finger	611..631	CDD:275368	9/20 (45%)
		C2H2 Zn finger	639..659	CDD:275368	4/20 (20%)
		C2H2 Zn finger	667..687	CDD:275368	6/64 (9%)
		COG5048	691..1133	CDD:227381	110/585 (19%)
		C2H2 Zn finger	695..715	CDD:275368	4/21 (19%)
		zf-H2C2_2	707..732	CDD:290200	3/26 (12%)
		C2H2 Zn finger	723..743	CDD:275368	4/28 (14%)
		C2H2 Zn finger	751..771	CDD:275368	1/19 (5%)
		zf-H2C2_2	764..788	CDD:290200	2/24 (8%)
		C2H2 Zn finger	779..799	CDD:275368	2/19 (11%)
		C2H2 Zn finger	807..827	CDD:275368	5/19 (26%)
		C2H2 Zn finger	835..855	CDD:275368	6/20 (30%)
		C2H2 Zn finger	863..883	CDD:275368	3/19 (16%)
		zf-H2C2_2	876..899	CDD:290200	7/29 (24%)
		C2H2 Zn finger	891..911	CDD:275368	6/20 (30%)
		C2H2 Zn finger	919..939	CDD:275368	5/20 (25%)
		C2H2 Zn finger	947..967	CDD:275368	8/37 (22%)
		C2H2 Zn finger	976..995	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1003..1023	CDD:275368	3/19 (16%)
		zf-H2C2_2	1015..1039	CDD:290200	7/47 (15%)
		C2H2 Zn finger	1031..1051	CDD:275368	7/40 (18%)
		C2H2 Zn finger	1059..1079	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1087..1107	CDD:275368	5/20 (25%)
		zf-H2C2_2	1099..1124	CDD:290200	7/25 (28%)
		C2H2 Zn finger	1115..1135	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1143..1163	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1171..1191	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1199..1219	CDD:275368	6/21 (29%)
		zf-H2C2_2	1212..1236	CDD:290200	7/23 (30%)
		C2H2 Zn finger	1227..1247	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1255..1275	CDD:275368	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930