DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and zfat

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_012820307.2	Gene:	zfat / 734084	XenbaseID:	XB-GENE-981323	Length:	1212	Species:	Xenopus tropicalis

Alignment Length:	1240	Identity:	231/1240 - (18%)
Similarity:	390/1240 - (31%)	Gaps:	505/1240 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 SRVYSCDMCLFETSTVSQLRTHYKERHTVQPTE-----VQLRPSWTGEPTTTRGVAAKQQTPAKI 496
            |.::.|.:|...:...|:|..|..:.||.:...     :.|||           :||..::
Frog    11 SSIFMCKLCNLFSPNHSELVLHVSDNHTEEGLTAGDIIIPLRP-----------LAASNRS---- 60

  Fly   497 LNHTDIPLGIKYPPGVLETQAPLPQPVVHQPMPDPMQQTEPMATTSTTITESGDINVVVDATPLF 561
               .|....:|...|                        .|..:|..:|.|
Frog    61 ---GDDLSAVKRKRG------------------------RPKGSTKKSIAE-------------- 84

  Fly   562 YAATSNSLLVTNPAPVTTVEETTGTASNHAFGIFPEISEGNLPVNEAVQQAPANSSSVSVFGDMQ 626
                               ||:|..:||.:..:.||..|...||.|.::....:.:    |.:::
Frog    85 -------------------EESTEQSSNASGDLLPETDEKPDPVPENLECRKCSRT----FSNVR 126

  Fly   627 DFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAENLFEDFEEEEDDTVADEEDEADNE 691
            ....:     ||.|      |::.|:.|...|    ||:.:     |.:.|.|...:.:.:....
Frog   127 QLKKH-----ICII------VLNDDEDVTSGN----DFEGK-----FIQPESDKERERQPKRSRV 171

  Fly   692 DENDNNDAATDQN----------LLLTSD-------------------DDDVDDFDDEQSKHLQK 727
            .:.|.:....|.:          :|||:.                   :.:::....||.:..:|
Frog   172 QKTDKSAQPKDSDKAQGVHPIVRVLLTAHEAIPGATKIIPIEAETPEAEPEINPQTSEQEQVQRK 236

  Fly   728 PY----------------------------CIYCNKKFTSQYKFENHMFVHRGLAPYRCELCT-- 762
            .|                            |.||||.|..::..:.|:.:|....||:|.||:
Frog   237 GYQEYAIQQIPTELATKANRVGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTKEKPYKCSLCSYA 301

  Fly   763 -----NL------------------------------------------------YNMKRLLIKH 774
                 ||                                                |:..:.||||
Frog   302 SAIKANLSVHMRKHTGEKFSCDHCTFSCLSKGHLKVHVERVHKKIKQHCRFCKKKYSDVKNLIKH 366

  Fly   775 YKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLM-CAKCPFECESDSEMRKHLNAHH 838
            .|..|..:..:  ||...|::        :|.....|..:|. |..|..:.:::.|..:|:..|.
Frog   367 IKETHDLLDKK--VQETFDEL--------RLLTREGKRQLLYDCHICERKFKNELERDRHMLVHG 421

  Fly   839 G--------INDGVSEHANEVFIIRKLPF--ECPRCIRSFAAKTTLSRHLQRSH------LV--D 885
            .        ...|.:::.:....|||.||  .|..|.:.|.:...|..|::..|      ||  |
Frog   422 DERPFACELCGHGATKYQSLELHIRKHPFVYVCSFCCKKFVSTVRLKAHIKERHSDAQEALVYND 486

  Fly   886 TI------IEMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHN---EMMQTDVGAEKMTEALG 941
            :|      :|..:....||:        ..|..|...:|::|..:   |:..|.......|:|||
Frog   487 SINQSFCLLEPGSDIQPEAL--------RDIENPAKPLTLNGDLSLVPELHSTGQENTIQTDALG 543

  Fly   942 -NGDGNEEG-----------GT-----DDGTGVKAEPA---------------VP---------- 964
             ..:|.:|.           ||     ::|...||.|.               ||
Frog   544 TTSEGQQESMGAFQVAEKEPGTCLPILENGVDPKAGPLSTLGSVENEISCKGFVPLSSENENNHF 608

  Fly   965 EEELDPVT-LDAATAVTTTA---IAAAI---------SAAAAATATSLESPVATTASSSTTLFPT 1016
            ..|.:||. |.:|.|....|   :.:|:         |....:|..:...|..||..||..|...
Frog   609 SSEHEPVEGLHSAPATNQAADNILGSAVLEEGARNVSSRTEQSTEVAEGGPNPTTEPSSHLLASN 673

  Fly  1017 PTP----------------------------------------------FDFDYDI-MRDEAQQS 1034
            |.|                                              :...||: :|...::
Frog   674 PPPSSPGETAAFMAILNGLHKRQLSTALMQKIRKIYGELECEYCGKLFWYQVHYDMHVRTHTRE- 737

  Fly  1035 SPNIHDVSKALSDNASSSC----PINESYKLLSTTALE----TSPAK-GLRSNSRLH---RSSIH 1087
              :::..|:....:.:.:|    .|.:...||.....|    :||.| .|:::.::|   ....:
Frog   738 --HLYYCSQCSYSSITKNCLKRHVIQKHSSLLLKCPSEGCNYSSPDKYKLQTHIKIHTDLEKKTY 800

  Fly  1088 ICKLCNQTFDE-----------------------LGKLVK-----------------HEMELHSN 1112
            .|..|.::|.:                       ||:.|:                 :.|:..|:
Frog   801 SCPSCEKSFSDDRLIKSHIKTNHPEVPSSLISEVLGRKVQMKGLIGKRAVKCPFCDSYFMKNGSD 865

  Fly  1113 TERSRWGYQ----HKCAICNTSYRTLTLLKFHMKRHSNRKSQ-CKLCPKSFVTIAELERHTKAKH 1172
            .:|..|.::    .||::|:.:.|:.:.||.||.|||..|:. |.:|.|.|.:...|:.| |..|
Frog   866 LQRHIWAHEGLKPFKCSMCDYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSH-KLLH 929

  Fly  1173 SKD-KTLRCFMDGCRKTFAFKHHLIRHQKASHLSTR-YICPVCNKEEKSNVHLKNH--------- 1226
            :.| |..:|.:  |..|...|.||:||.: .|.|.: :.|.:|:........||.|
Frog   930 TSDGKQFKCTV--CEFTAVQKRHLVRHME-QHTSFKPFGCALCHYSCNIPGSLKRHYNKKHPDKQ 991

  Fly  1227 -MSVHKGEIT---------YKCPKCDRSY-----------LRRG-RLV----------------- 1252
             ::...|||:         .|||.|...|           .:.| :||
Frog   992 CVNAGTGEISQEAVLLQGGMKCPVCSFVYGTKWEFNRHLKNKHGLKLVENEGDAKWESLDTTEET 1056

  Fly  1253 ----------------THALI--IHDLRFTTEELGNLSSLATN--------QARPND-LKVATPV 1290
                            |.|.:  :.|||:|::....|...|.|        .|.|:| ..||:.|
Frog  1057 CTQYLHIADTETDVQGTEAAVAALQDLRYTSDTSDKLDPTAVNILQQIIELGAEPHDAAAVASVV 1121

  Fly  1291 GLLDG 1295
            .:..|
Frog  1122 AMAPG 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368	5/17 (29%)
		C2H2 Zn finger	730..750	CDD:275368	7/19 (37%)
		C2H2 Zn finger	758..777	CDD:275368	10/73 (14%)
		C2H2 Zn finger	1089..1110	CDD:275368	7/60 (12%)
		C2H2 Zn finger	1124..1144	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1151..1172	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1180..1203	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1210..1230	CDD:275368	5/29 (17%)
		C2H2 Zn finger	1238..1254	CDD:275368	7/60 (12%)
zfat	XP_012820307.2	zf-C2H2	265..287	CDD:395048	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		zf-H2C2_5	293..317	CDD:404746	6/23 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		C2H2 Zn finger	322..343	CDD:275368	0/20 (0%)
		C2H2 Zn finger	350..371	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	428..448	CDD:275368	3/19 (16%)
		C2H2 Zn finger	454..472	CDD:275368	5/17 (29%)
		C2H2 Zn finger	714..734	CDD:275368	3/19 (16%)
		zf-H2C2_5	740..764	CDD:404746	3/23 (13%)
		C2H2 Zn finger	742..792	CDD:275368	10/49 (20%)
		COG5048	<761..926	CDD:227381	36/165 (22%)
		C2H2 Zn finger	802..821	CDD:275368	3/18 (17%)
		C2H2 Zn finger	852..873	CDD:275368	4/20 (20%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		C2H2 Zn finger	909..929	CDD:275368	7/20 (35%)
		zf-H2C2_5	936..959	CDD:404746	8/25 (32%)
		C2H2 Zn finger	938..958	CDD:275368	8/22 (36%)
		C2H2 Zn finger	966..987	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1013..1031	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100