DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30020 and Zfp689

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_780372.2	Gene:	Zfp689 / 71131	MGIID:	1918381	Length:	500	Species:	Mus musculus

Alignment Length:	539	Identity:	97/539 - (17%)
Similarity:	148/539 - (27%)	Gaps:	224/539 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   728 PYCIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKG 792
            |.|..|...|......|:|........||.|..|...::...||:.| :..|.
Mouse   149 PICPDCGCTFPDHLALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSH-RRAHS------------ 200

  Fly   793 DKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSE---MRKHLNAHHGINDGVSEHANEVFII 854
                                     .:||:.|:...:   .||:|:.|..|:.|
Mouse   201 -------------------------GECPYVCDQCGKRFSQRKNLSQHQVIHTG----------- 229

  Fly   855 RKLPFECPRCIRSFAAKTTLSRHL-----QRSHLVDTIIEMQTPHCGE--AITTTMATSSSTISE 912
             :.|:.||.|.|.|....:|:.|.     ::.|        |.|.||.  |..:.:|....|
Mouse   230 -EKPYHCPDCGRCFRRSRSLANHRTTHTGEKPH--------QCPSCGRRFAYPSLLAIHQRT--- 282

  Fly   913 PVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAAT 977
                      |                               ||.|           |.|.
Mouse   283 ----------H-------------------------------TGEK-----------PYTC---- 291

  Fly   978 AVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVS 1042
                                                          .:..|...|:::..||
Mouse   292 ----------------------------------------------LECSRRFRQRTALVIH--- 307

  Fly  1043 KALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHR-SSIHICKLCNQTFDELGKLVKHE 1106
                                                .|:|. ...:.|..|.:.|....:||.|.
Mouse   308 ------------------------------------QRIHTGEKPYPCPDCERRFSSSSRLVSHR 336

  Fly  1107 MELHSNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKS-QCKLCPKSFVTIAELERHTKA 1170
             .:||. ||     .:.|..|...:...:.|..|...|:..|. .|..|.::|.....|..| ::
Mouse   337 -RVHSG-ER-----PYACENCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRRSGSLAIH-RS 393

  Fly  1171 KHSKDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEIT 1235
            .|:::|...|  |.|.:.||:...|..|::.......|.|.:|:|......||..|..:|.||..
Mouse   394 THTEEKLHAC--DDCGRRFAYPSLLASHRRVHSGERPYACDLCSKRFAQWSHLSQHQLLHTGEKP 456

  Fly  1236 YKCPKCDRSYLRRGRLVTH 1254
            :.|.:|.|.:.:|..|..|
Mouse   457 FPCLECGRCFRQRWSLAVH 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368	5/19 (26%)
		C2H2 Zn finger	758..777	CDD:275368	5/18 (28%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1151..1172	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1180..1203	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1210..1230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1238..1254	CDD:275368	5/15 (33%)
Zfp689	NP_780372.2	KRAB	29..88	CDD:214630
		KRAB	29..68	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..144
		C2H2 Zn finger	151..171	CDD:275368	5/19 (26%)
		COG5048	171..>466	CDD:227381	88/506 (17%)
		C2H2 Zn finger	179..199	CDD:275368	5/20 (25%)
		C2H2 Zn finger	207..227	CDD:275368	5/19 (26%)
		zf-H2C2_2	219..244	CDD:290200	10/36 (28%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		zf-H2C2_2	247..272	CDD:290200	7/32 (22%)
		C2H2 Zn finger	263..283	CDD:275368	6/32 (19%)
		zf-H2C2_2	276..300	CDD:290200	9/128 (7%)
		C2H2 Zn finger	291..311	CDD:275368	5/108 (5%)
		zf-H2C2_2	303..328	CDD:290200	7/63 (11%)
		C2H2 Zn finger	319..339	CDD:275368	6/20 (30%)
		zf-H2C2_2	332..356	CDD:290200	9/30 (30%)
		C2H2 Zn finger	347..367	CDD:275368	4/19 (21%)
		zf-H2C2_2	360..384	CDD:290200	7/23 (30%)
		C2H2 Zn finger	375..395	CDD:275368	5/20 (25%)
		C2H2 Zn finger	403..423	CDD:275368	7/21 (33%)
		zf-H2C2_2	416..440	CDD:290200	6/23 (26%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		C2H2 Zn finger	459..475	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930