DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and ZNF462

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_006717272.1	Gene:	ZNF462 / 58499	HGNCID:	21684	Length:	2567	Species:	Homo sapiens

Alignment Length:	1547	Identity:	274/1547 - (17%)
Similarity:	439/1547 - (28%)	Gaps:	612/1547 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 HECQVCGVVLYNRLELKQHIRQH-----------AEGLSYNCKLCSFTSLKQRTLFEHYVTMH-N 192
            :.|..|.:...|..:|:||..:|           ...|.|.|:.||:||...|:|..||..|| .
Human   886 YRCLECYIDYTNFEDLQQHYGEHHPEAMNVLNFDHSDLIYRCRFCSYTSPNVRSLMPHYQRMHPT 950

  Fly   193 MPLSQA---EEYVKSKH--------------------------------LPAPKEEEVKAVCTLE 222
            :.::.|   ..||..:.                                |||...:......|.|
Human   951 VKINNAMIFSSYVVEQQEGLNTESQTLREILNSAPKNMATSTPVARGGGLPATFNKNTPKTFTPE 1015

  Fly   223 ---DMELLIPTVL----------RPE------DYVQPHPHIDNDQLR--------DIDH-----Q 255
               ..:.|:.||:          .|.      .|.:.||.......|        .:|.     |
Human  1016 CENQKDPLVNTVVVYDCDVCSFASPNMHSVLVHYQKKHPEEKASYFRIQKTMRMVSVDRGSALSQ 1080

  Fly   256 LAVSMDEPV-PSVDSLTSTLPPMDTPNVSIGTEYLVLPDGSLQQVNGSGVVIEYIDDSKPNSSSN 319
            |:..:..|: |.:.::.|. ||...|...:.||.......|....:..||::.|
Human  1081 LSFEVGAPMSPKMSNMGSP-PPPQPPPPDLSTELYYCKHCSYSNRSVVGVLVHY----------- 1133

  Fly   320 VNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKS 384
                                     ::..|:|::              ..|:..:...|.|.::.
Human  1134 -------------------------QKRHPEIKV--------------TAKYIRQAPPTAAMMRG 1159

  Fly   385 --------------HQLTHSNLPK---------FFCDQCDFYSLRSADLIQHYKMVHHRVDENGK 426
                          .||..|:..:         |||..||:.:.....::.||:..|.....|..
Human  1160 VEGPQGSPRPPAPIQQLNRSSSERDGPPVENEMFFCQHCDYGNRTVKGVLIHYQKKHRDFKANAD 1224

  Fly   427 TGKEQAQGIES---------------------------RVYSCDMCLFETSTVSQLRTHYKERHT 464
            ..::....|.|                           |...|..|.:.:.....||.|.|:.|.
Human  1225 VIRQHTATIRSLCDRNQKKPASCVLVSPSNLERDKTKLRALKCRQCSYTSPYFYALRKHIKKDHP 1289

  Fly   465 VQPTEVQLRPSWTGEPTTTRG-VAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQ-- 526
            .....|.....|    ....| :.|.......|.:||: |.|:     :|..|...|:..|..
Human  1290 ALKATVTSIMRW----AFLDGLIEAGYHCEWCIYSHTE-PNGL-----LLHYQRRHPEHYVDYTY 1344

  Fly   527 --------PMPDPMQQTEPM-------------ATTSTTITE----------SGDINVVVDATPL 560
                    |.|.|...|.|.             |.:...||.          :||.:|::|
Human  1345 MATKLWAGPDPSPPSLTMPAEAKTYRCRDCVFEAVSIWDITNHYQAFHPWAMNGDESVLLD---- 1405

  Fly   561 FYAATSNSLLVTNPA---PVTTVEETTG--TASNHAFGIFPE-----ISEGNLPVNEAVQQAPAN 615
                    ::....|   |:.:.||..|  ...|.....|||     ..:..|...:::|.|.||
Human  1406 --------IIKEKDAVEKPILSSEELAGPVNCENSIPTPFPEQEAECPEDARLSPEKSLQLASAN 1462

  Fly   616 SSSVSVFGDMQDFIDNTDVAAICTI-----------------PADGMPVVDGD---DIVID---- 656
            .:           |.:|...  ||:                 ...||.|...|   ||.|:
Human  1463 PA-----------ISSTPYQ--CTVCQSEYNNLHGLLTHYGKKHPGMKVKAADFAQDIDINPGAV 1514

  Fly   657 ---------NNNI------------SLDFDAENLFEDFEEEEDDTVADEEDEADNEDENDNNDAA 700
                     |..|            |:...||:...|.|:..|
Human  1515 YKCRHCPYINTRIHGVLTHYQKRHPSIKVTAEDFVHDVEQSAD---------------------- 1557

  Fly   701 TDQNLLLTSDDDDVDDFDDEQSKHLQKPYCIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLY 765
            ..||             |.|::..:.|                       :|...|||:||...:
Human  1558 ISQN-------------DVEETSRIFK-----------------------QGYGAYRCKLCPYTH 1586

  Fly   766 NMKRLLIKHYKTVHKRMPTRDMVQAKGDK------------VSVARTNIEKLYPGR--------- 809
            .....|..||:..|.: |..|:......|            ||.::.:|.:...|.
Human  1587 GTLEKLKIHYEKYHNQ-PEFDVFSQSPPKLPVPLEPEMTTEVSPSQVSITEEEVGEEPVSTSHFS 1650

  Fly   810 ----IKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLP------FECPRC 864
                :.:.:..|..|.:.|.:    ||.:..|:.|     :|.|    :|..|      |:|..|
Human  1651 TSHLVSHTVFRCQLCKYFCST----RKGIARHYRI-----KHNN----VRAQPEGKNNLFKCALC 1702

  Fly   865 IRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSSSTISEPVNSVTVDG-------Q 922
            ..:...:..|:.|.|:.|.:|...    .||        ..:|.|||:..|.|.:..       |
Human  1703 AYTNPIRKGLAAHYQKRHDIDAYY----THC--------LAASRTISDKPNKVIIPSPPKDDSPQ 1755

  Fly   923 HNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAV-PEEELDPVTLDAATAVTTTAIAA 986
            .:|.::..|  ||...:|.:.....:.|..... :|..|.| |:::.........|||
Human  1756 LSEELRRAV--EKKKCSLCSFQSFSKKGIVSHY-MKRHPGVFPKKQHASKLGGYFTAV------- 1810

  Fly   987 AISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSS--PNIHDVSKALSDNA 1049
                    .|...|.|         ||.......:|:...:..|||:..  |
Human  1811 --------YADEHEKP---------TLMEEEERGNFEKAEVEGEAQEIEWLP------------- 1845

  Fly  1050 SSSCPINESYKLLSTTALETSPAKGLRSNSRLHRS------------------SIHICKLCNQTF 1096
                     ::.:....|..|.|:.|..:...|.|                  |.:.||.|:...
Human  1846 ---------FRCIKCFKLSFSTAELLCMHYTDHHSRDLKRDFIILGNGPRLQNSTYQCKHCDSKL 1901

  Fly  1097 DELGKLVKHEMELHSN--------------------------------------------TERSR 1117
            ....:|..| :.:|:.                                            .||..
Human  1902 QSTAELTSH-LNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLEEVPKIKERKV 1965

  Fly  1118 WGYQHKCAICNTSYRTLTLLKFHMKRHSNRKS--------------------------------- 1149
            .||  ||..|...:.||..:..|:::|....:
Human  1966 VGY--KCKFCVEVHPTLRAICNHLRKHVQYGNVPAVSAAVKQEADDPAHLFLDGLEAAKDASGAL 2028

  Fly  1150 ------------------------QCKLCPKSFVTIAELERHTK-----AKHSKDKTLRCFMDGC 1185
                                    .|..|.:..:::..|..|.:     |..:::....|  ..|
Human  2029 VGRVDGEHCLLDGMLEDETRPGGYHCSQCDRVLMSMQGLRSHERSHLALAMFTREDKYSC--QYC 2091

  Fly  1186 RKTFAFKHHLIRHQKASHLSTR-YICPVCNKEEKSNVHLKNH-MSVHKGEITYKCPKCDRSYLRR 1248
            ....||:|:|.||.:..|...: :.|.:|:.:...|..||.| :..|.||..|||..|..|.:..
Human  2092 SFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTI 2156

  Fly  1249 GRLVTHALIIHDLRFTTEELGNLSSLATNQARPNDLKVATPVGLLDGRKDVS 1300
            .:|..|:|.:|....|... ..:.||.::.:..:..| |||...::...|.|
Human  2157 SQLKEHSLKVHGKALTLPR-PRIVSLLSSHSHHSSQK-ATPAEEVEDSNDSS 2206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368	5/33 (15%)
		C2H2 Zn finger	397..418	CDD:275368	5/20 (25%)
		C2H2 Zn finger	442..460	CDD:275368	5/17 (29%)
		C2H2 Zn finger	730..750	CDD:275368	0/19 (0%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1124..1144	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1151..1172	CDD:275368	5/25 (20%)
		C2H2 Zn finger	1180..1203	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1210..1230	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1238..1254	CDD:275368	4/15 (27%)
ZNF462	XP_006717272.1	C2H2 Zn finger	2054..2074	CDD:275368	4/19 (21%)
		C2H2 Zn finger	2088..2108	CDD:275368	8/21 (38%)
		C2H2 Zn finger	2117..2138	CDD:275368	6/20 (30%)
		zf-H2C2_5	2144..2169	CDD:316431	9/24 (38%)
		C2H2 Zn finger	2146..2167	CDD:275368	6/20 (30%)
		C2H2 Zn finger	2317..2337	CDD:275368
		C2H2 Zn finger	2363..2383	CDD:275368
		C2H2 Zn finger	2391..2412	CDD:275368
		C2H2 Zn finger	2477..2497	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100