DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30020 and LOC568955

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_697406.4	Gene:	LOC568955 / 568955	-ID:	-	Length:	541	Species:	Danio rerio

Alignment Length:	688	Identity:	127/688 - (18%)
Similarity:	207/688 - (30%)	Gaps:	298/688 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 TIPAD-GMPVVD-GDDIVIDNNNISLDFDAENLFEDFEEEEDDTV-------------------- 681
            ::.|| ||||.. .|:.....|.:.::.|.|:. .|.|.|.::..
Zfish    58 SVAADMGMPVYGFSDEDCSSYNRLGIESDFEDP-RDTESEREEMAPEAAFAPYLSCRQCGQLLGD 121

  Fly   682 ------------ADEEDE-------ADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQK 727
                        .|.:|.       |||..||.|: :.:|.|...|. ...:..|....|.||::
Zfish   122 PLSGLYCLQCGETDRQDRSLEPTHPADNTLENLNH-SRSDGNTSKTF-SCKLCSFSSRYSNHLKR 184

  Fly   728 -------------PYCIYCNKKFTSQYKFENHMFVHRGLAPYRCELCT----NLYNMKRLLIKHY 775
                         |:|:|.:.:..:   .:.|:..|.|..||:|:.||    :|.|:||
Zfish   185 HMKTHNGEKPYQCPHCVYASAQLVN---LQRHVRTHTGEKPYKCQFCTFACNSLGNLKR------ 240

  Fly   776 KTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGI 840
               |:||.|::                          ..|.||.|.|...:...::||..:|.
Zfish   241 ---HQRMHTQE--------------------------KELSCAHCDFRASNSHSLKKHTKSHK-- 274

  Fly   841 NDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMAT 905
                                        ..|||                        |:|.....
Zfish   275 ----------------------------EDKTT------------------------ALTEESVV 287

  Fly   906 SSSTI---SEPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEE 967
            |..|:   |:|......|..||..:.:.:....:..             ::|...:::| :||
Zfish   288 SDLTLHISSDPDFLQNYDHHHNHHLPSHLPPPALLH-------------NEGLSGESDP-LPE-- 336

  Fly   968 LDPVTLDAATAVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDI---MRD 1029
                                                        .|||      |...:   :.|
Zfish   337 --------------------------------------------LLFP------FSCRVCGAVLD 351

  Fly  1030 EAQQSSPNIHDVSKALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHICKLCNQ 1094
            :.:.::|.|  .||...|..|.|.| ::..||...|:                      |....|
Zfish   352 DEEATAPQI--CSKCTLDMLSKSSP-DKDDKLFPCTS----------------------CPFVTQ 391

  Fly  1095 TFDELGKLVKHEMELHSNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKS-QCKLCPKSF 1158
            ..:.|.:    .|:.||..:      .:||..|:.:......||.|.:.|:..|. :|::|..:.
Zfish   392 YPNHLAR----HMKTHSGEK------PYKCPQCSYASAHFDNLKRHHRVHTGEKPYKCRVCDYAC 446

  Fly  1159 VTIAELERHTKAKHSKDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHL 1223
            ..:|.|:||.:. ||..|..:                              |.||:.....:::|
Zfish   447 GNLANLKRHERI-HSGSKPFQ------------------------------CSVCSYSCNQSMNL 480

  Fly  1224 KNHMSVHKGEITYKCPKCD------RSYLRRGRLVTHA 1255
            |.||..|.||..:||..|.      .:|.|..:...||
Zfish   481 KRHMLRHTGEKPFKCQHCGYTTGHWDNYKRHQKKHGHA 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368	3/19 (16%)
		C2H2 Zn finger	758..777	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1089..1110	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1124..1144	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	0/22 (0%)
		C2H2 Zn finger	1210..1230	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1238..1254	CDD:275368	4/21 (19%)
LOC568955	XP_697406.4	C2H2 Zn finger	169..189	CDD:275368	4/19 (21%)
		zf-H2C2_2	181..206	CDD:290200	5/24 (21%)
		COG5048	193..>467	CDD:227381	82/497 (16%)
		C2H2 Zn finger	197..217	CDD:275368	4/22 (18%)
		zf-H2C2_2	209..234	CDD:290200	8/27 (30%)
		C2H2 Zn finger	225..245	CDD:275368	9/28 (32%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	383..403	CDD:275368	5/45 (11%)
		zf-H2C2_2	395..420	CDD:290200	7/34 (21%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
		zf-H2C2_2	423..446	CDD:290200	7/22 (32%)
		C2H2 Zn finger	439..459	CDD:275368	6/20 (30%)
		zf-H2C2_2	451..476	CDD:290200	9/55 (16%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		zf-H2C2_2	479..502	CDD:290200	10/22 (45%)
		C2H2 Zn finger	495..515	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100