DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30020 and si:dkey-154p10.3

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_692110.2	Gene:	si:dkey-154p10.3 / 563659	ZFINID:	ZDB-GENE-070912-380	Length:	646	Species:	Danio rerio

Alignment Length:	867	Identity:	147/867 - (16%)
Similarity:	259/867 - (29%)	Gaps:	334/867 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 EPVQPLKTMRHECQVCGVVLYN-RLELKQHIRQHAEGL---SYNCKLCSFTSLKQRTLFEHYVTM 190
            :.|||:.....|..|...:..| .:.::.|:....|..   .|.|::|.|||..:..:..|.:..
Zfish     9 QDVQPVTLRLAEENVTSSLYCNSAVGIEAHVSTLVEAFLVEVYRCRICQFTSSHKAKISHHVMER 73

  Fly   191 HNMPLSQAEEYVKSKHLPAPKEEEVKAVCTLEDMELLIPTVLRPEDYVQPHPHIDNDQLRDIDHQ 255
            |: |:|..      .|||..::|:.:::|    :|:.:    ..|:.|:   |..:....:.|.|
Zfish    74 HD-PVSPC------PHLPCLEKEDEESLC----VEMRV----NDEEEVE---HNSSPYDLESDLQ 120

  Fly   256 LAVSMDEPVPSVDSLTSTLP---------PMDTPNVSIGTEYLVLPDGSLQQVNGSGVVIEYIDD 311
            .....:|....::.::..||         |... ::.:|:.    .||:|.......|...:.:|
Zfish   121 SGSKSNEDQMDMERISFLLPMYGMFQNISPRSC-DIGLGSS----SDGNLHVAQTCEVSTLFEED 180

  Fly   312 SKPNSSSNVNV-----SLQNLLSSHNDPMDIDVNELIVEEMMPQIRI-------------KPKPA 358
            ...::|....|     :..:|....|..||.:|.:   |||.....:             :|..|
Zfish   181 RHDDNSDEERVFQLEDASTDLTVPLNSGMDTEVQD---EEMAQSAHLMTLGLCRISSTKGQPSSA 242

  Fly   359 VIGTSIHKHK----------------------CKFCPKTFSTVARLKSHQLTHSNLPKFFCDQCD 401
            ....|:.:.:                      |..|....|:...|..|...||....|.|.:|.
Zfish   243 TSAKSLPEGEQDAGDASMDAVMQKTEEDGGLACILCQTVASSRVMLDVHLKCHSGEQGFRCPRCG 307

  Fly   402 FYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMCLFETSTVSQLRTHYKERHTVQ 466
            :.|...||:..|:::  |        ||.:.    ::.:.|.:|. .:...:..|..::|||..|
Zfish   308 WESEEWADMEHHWRL--H--------GKRKG----TKRHRCSVCP-RSFRRADSRDAHEERHNHQ 357

  Fly   467 PTEVQLRPSWTGEPTT---------------------TRG------VAAKQQTPAKILNHTDIPL 504
            ...   |.|.:|||..                     .:|      ...|::|..|.|.|
Zfish   358 RHH---RRSESGEPVQCSFCLEWCHSGKEWEIHQHCHVQGGFKCLHCDFKEKTWKKTLKH----- 414

  Fly   505 GIKYPPGVLETQAPLPQPVVHQPMPDPMQQTEPMATTSTTITESGDINVVVDATPLFYAATSNSL 569
                               :|      .|..:..|.....|..|.||
Zfish   415 -------------------IH------TQHKQAEANQDNQIAHSRDI------------------ 436

  Fly   570 LVTNPAPVTTVEETTGTASNHAFGIFPEISEGNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDV 634
                       ::.:.:|.      :||......|
Zfish   437 -----------QQLSSSAK------YPECLRRMQP------------------------------ 454

  Fly   635 AAICTIPADGMPVVDGDDIVIDNNNISLDFDAENLFEDFEEE--EDDTVADEEDEADNEDENDNN 697
                                             .|:....::  ::..|..|:.....:|...:.
Zfish   455 ---------------------------------ELWSQIRKKKVKNRAVGKEKSNEGGKDRVKHL 486

  Fly   698 DAATDQNLLLTSDDDDVDDFDDEQSKHLQKPYCI-YCNKKFTSQYKFENHMFVHRGLAPYRCELC 761
            .|.|...|.:|.                :|.:|. .|:|||:::.....||.:|:|..|::|..|
Zfish   487 KAETSVGLTVTR----------------RKEFCCNLCDKKFSTKLTMRRHMGIHQGDKPFKCPHC 535

  Fly   762 TNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECES 826
            .....:|..||:|.: :|..                     ||.|         .|.:|.:....
Zfish   536 HYCTRLKASLIQHLR-IHTG---------------------EKPY---------KCLQCSYASID 569

  Fly   827 DSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDT----I 887
            .|.:|:|...|                .::.|:.|..|..|...|..|..|.:|.|..::    :
Zfish   570 RSSLRRHSRTH----------------TQEKPYCCQYCPYSSIQKKCLDLHSRRHHTGESFPCHL 618

  Fly   888 IEMQTP------------HCGE 897
            .:..||            |.||
Zfish   619 CQYSTPDRQLLVRHMRKHHTGE 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368	5/19 (26%)
		C2H2 Zn finger	397..418	CDD:275368	6/20 (30%)
		C2H2 Zn finger	442..460	CDD:275368	3/17 (18%)
		C2H2 Zn finger	730..750	CDD:275368	7/20 (35%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368
		C2H2 Zn finger	1124..1144	CDD:275368
		C2H2 Zn finger	1151..1172	CDD:275368
		C2H2 Zn finger	1180..1203	CDD:275368
		C2H2 Zn finger	1210..1230	CDD:275368
		C2H2 Zn finger	1238..1254	CDD:275368
si:dkey-154p10.3	XP_692110.2	C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		C2H2 Zn finger	303..323	CDD:275368	6/21 (29%)
		C2H2 Zn finger	334..350	CDD:275368	3/16 (19%)
		COG5048	<500..632	CDD:227381	38/178 (21%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		zf-H2C2_2	517..539	CDD:290200	7/21 (33%)
		C2H2 Zn finger	532..552	CDD:275368	6/20 (30%)
		C2H2 Zn finger	560..580	CDD:275368	5/19 (26%)
		zf-H2C2_2	572..594	CDD:290200	6/37 (16%)
		C2H2 Zn finger	588..608	CDD:275368	6/19 (32%)
		C2H2 Zn finger	616..636	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100