DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30020 and znf142

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_690036.3	Gene:	znf142 / 561536	ZFINID:	ZDB-GENE-080512-2	Length:	1535	Species:	Danio rerio

Alignment Length:	1371	Identity:	254/1371 - (18%)
Similarity:	430/1371 - (31%)	Gaps:	456/1371 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QHICLECSKSLQVAYYFLQNALRAHEILCRKLCPKVSKR------LNGTLAQEQEKPACAEPVQP 134
            ||:|.||....:..:| |...:|.|....|..|.:.|.|      ||....:.|||...
Zfish   377 QHMCSECGYVTKWKHY-LSVHMRKHAGDLRYKCNQCSYRCHRMDQLNSHRLRHQEKSLI------ 434

  Fly   135 LKTMRHECQVCGVVLYNRLELKQHIR-QH-----AEGLSYNCKLCSFTSLKQRTLFEH------- 186
                   |:||......:.||:.|:: :|     |:...|.||.|.:|:..::.|..|
Zfish   435 -------CEVCAYSCKRKTELRSHMQLKHSTNADAQPPVYQCKFCPYTTKYRQALLSHENCRHTR 492

  Fly   187 ----------YVTMHNMPL----SQAEEYVKSKHL----PAPKEEEVKAVCTLEDMELLIPTVLR 233
                      |.|..|..|    .::..||....:    .|.||:|..:| .|.| .....|..
Zfish   493 TRMFRCALCRYTTFSNTGLFLHKKKSHGYVPGDVIWLKNYAEKEKEQSSV-DLTD-NFFSKTAA- 554

  Fly   234 PEDYVQPHPHIDNDQLRDIDHQLAVSMDEPVPSVDSLTSTLPPMDTPNVSIG-TEYLVLPDGSLQ 297
                    |...|.:.|:                          :|.|.:|| ::.:.|.|...:
Zfish   555 --------PQTSNLEYRE--------------------------ETSNKTIGDSQDVSLNDNEDE 585

  Fly   298 QVNGSGVVIEYIDDSKPNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGT 362
            .:.......|.:.:..||..     ....||.|....|:       ..:|:|           ..
Zfish   586 AIRAPIAQTEKMTERHPNDE-----ECSTLLYSSQTSME-------STQMIP-----------AE 627

  Fly   363 SIHKHKCKFCPKTFSTVARLKSHQLTHSNLPK--------------FFC----DQCDFYSLRSAD 409
            :.:.|...|.....|.......|.: |.|:|:              .:|    |..|...|...:
Zfish   628 TANIHNTAFNVHIGSNAGSHTLHSI-HQNIPEPSAENEDDDDDDDGVYCRAQSDSEDLTQLTGFE 691

  Fly   410 LIQHYKMVHHRVDEN-----GKTGKEQAQG--IESRV-----------YSCDMCLFETSTVSQLR 456
            |.|. ..|.....|.     .|..|:||:.  :|.||           |.|..|.:.|...:.|.
Zfish   692 LHQD-SFVQPSTSETCLQVLRKQDKDQAKALVLEGRVQMLVVRTQDNMYQCSRCSYVTRKQAALV 755

  Fly   457 THYKERHTVQPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNHT-------DIPLGIKYPPGVLE 514
            .|.|....|..|.::.:..         |:..|||...    ||       .:|.|.|
Zfish   756 RHSKTSCQVMKTGLRCQDC---------GMHFKQQRSL----HTHRLRKCRSLPSGGK------- 800

  Fly   515 TQAPLPQP-------VVHQPMPDPMQQTEPMATTSTTITESGDINVVVDATPLFYAATSNSLLVT 572
             ::.||..       |.|....:.:..|..:...|..:|   |:.:...|.|      ..||
Zfish   801 -KSDLPNAIGKSERCVGHSRSTNLISGTPTIQIESLEVT---DLRLKGSAEP------QGSL--- 852

  Fly   573 NPAPVTT--VEETTGTASNHAFG-----IFPEISEGNLPVNEAV----QQAPANSSSVSVFGDMQ 626
              :|:.|  ::||....|....|     ...::::.::.||:.|    ::....:.....|..::
Zfish   853 --SPIITDVIDETDSLPSTSEEGQATIRTINKLAKVDVSVNDEVSGYTEEGGRFTCRTCPFSSVR 915

  Fly   627 DFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAENLFEDFEEEEDDTVADEEDEADNE 691
            ....|.. .|.|:..|..:.:.:          ::..|:.|:.|.|.::|::|.....:.|.|:.
Zfish   916 KVTINRH-CATCSGSAPKIYLAE----------MAGQFEQEDHFNDSDQEDEDVDGANDSEGDSA 969

  Fly   692 -DENDNND-----------------------------------------AATDQNL---LLTSDD 711
             ||...:.                                         |.:|::|   :|:...
Zfish   970 VDERSPSSIPRFSCPNCPFLCHQKRALASHEVKGCLKQGEIQCPHCSFVAKSDKSLSHHILSHKK 1034

  Fly   712 D--------------DVDDFDDEQSKHLQ----------KPY-CIYCNKKFTSQYKFENHMFVHR 751
            |              |:..|..:|.:.|.          :|: |.:|:.....:|:.|.|..:|.
Zfish  1035 DKKATKGKRSGNLQCDLCSFTCKQERCLMQHVAVKHEGVRPHQCRFCSFSTVRRYRLEAHESMHT 1099

  Fly   752 GLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLM 816
            |:..:.||||...:.....|..|::.:|.:..|.                              .
Zfish  1100 GVGRHSCELCGQTFGTTSRLRLHHQRIHDKQATH------------------------------F 1134

  Fly   817 CAKCPFECESDSEMRKH-LNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQR 880
            |:.|.:...:.:::.:| |:.|.|                :|.:.|.:|...|::...|.:|..|
Zfish  1135 CSVCDYRAYNLNDINRHNLSCHTG----------------ELRYHCSQCDARFSSDGALKQHCHR 1183

  Fly   881 SHLVDTIIEMQTPHCGEAITT------TMATSSSTISEPVNSVTVDGQHN-EMMQTDVGAEKMTE 938
            .|     .:..|..|.:...|      ..|...|..||..|    |.|.| |.........|.|.
Zfish  1184 VH-----SDANTLPCTQCSFTCRGQAALKAHMQSDHSEKTN----DPQDNPEKRSKKSITHKCTV 1239

  Fly   939 ALGNG-----------DGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAA 992
            ...|.           |.:|:|              |.||
Zfish  1240 CSFNTNKRLLLVQHMLDEHEDG--------------PAEE------------------------- 1265

  Fly   993 AATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKALSDNASSSCPINE 1057
                              .||......|...:.::.|:..:|.              ..:|
Zfish  1266 ------------------KTLKCDVCGFSCTHQMVFDQHIRSH--------------GGTC---- 1294

  Fly  1058 SYKLLSTTALE--TSPAKGLRSNSRLHR-SSIHICKLCNQTFDELGKLVKHEMELHSNTERSRWG 1119
               |...|..|  |...:.:..:.|:|. ...:.|:.||....:..:| |:.|.:|.: ||
Zfish  1295 ---LFKCTECEFSTRNKQKITWHIRIHTGEKPYRCEKCNYACADPSRL-KYHMRIHMD-ER---- 1350

  Fly  1120 YQHKCAICNTSYRTLTLLKFHMKRHSNRKS-QCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMD 1183
             ::.|..|....:.:..||:||.:|:..|. .|:.|.........|..|.:.:|...::..|  :
Zfish  1351 -KYLCPECGYKCKWVNQLKYHMTKHTGAKPYACEDCEYRTNRADALRIHRETRHRDVRSFIC--E 1412

  Fly  1184 GCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRR 1248
            .|.|.|..:..|..||:....:..|:|.||.|..:....|::|...|..::.:.|..|.....::
Zfish  1413 KCGKAFKTRFLLKTHQRKHSEARPYVCSVCQKAFRWPAGLRHHYLSHTNQLPFYCLHCPYRAKQK 1477

  Fly  1249 GRLVTH 1254
            .::|.|
Zfish  1478 FQVVKH 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	9/29 (31%)
		C2H2 Zn finger	369..389	CDD:275368	3/19 (16%)
		C2H2 Zn finger	397..418	CDD:275368	6/24 (25%)
		C2H2 Zn finger	442..460	CDD:275368	5/17 (29%)
		C2H2 Zn finger	730..750	CDD:275368	5/19 (26%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1151..1172	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1180..1203	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1210..1230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1238..1254	CDD:275368	3/15 (20%)
znf142	XP_690036.3	COG5048	80..503	CDD:227381	33/139 (24%)
		C2H2 Zn finger	86..106	CDD:275368
		C2H2 Zn finger	114..134	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		C2H2 Zn finger	242..261	CDD:275368
		C2H2 Zn finger	266..316	CDD:275368
		C2H2 Zn finger	324..344	CDD:275368
		C2H2 Zn finger	352..372	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		C2H2 Zn finger	435..452	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1078..1098	CDD:275370	5/19 (26%)
		C2H2 Zn finger	1106..1127	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1135..1156	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1164..1185	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1193..1210	CDD:275368	3/16 (19%)
		C2H2 Zn finger	1270..1290	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1298..1318	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1326..1346	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1354..1374	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1382..1403	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1411..1431	CDD:275368	7/21 (33%)
		C2H2 Zn finger	1439..1459	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1467..1487	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5053
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000