DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and CG17803

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001303488.1	Gene:	CG17803 / 42141	FlyBaseID:	FBgn0038547	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	143/830 - (17%)
Similarity:	225/830 - (27%)	Gaps:	369/830 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   544 TITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGTASNHAF--GIFPEISEGNLPVN 606
            |:..|..:|..:  ..||.|...:|     .|..||......|.::.||  ..|.|.|.|
  Fly    22 TMRSSRQVNKKL--VKLFLAEADDS-----DATCTTSTALDTTTADSAFFDSDFEEESTG----- 74

  Fly   607 EAVQQA---PANSSS-----VSVFGDMQDFIDNTDVAAICTIPA-DGMPVVDG------------ 650
              :|:.   ||:...     :|...|.||..|..::|.:..|.. .|:.:..|
  Fly    75 --LQECDPPPASKCRTCFRIISRHEDAQDLYDRVNIALLHHIKVITGVWIQQGVKELPHHICSTC 137

  Fly   651 DDIVIDNNNISLDFDA-----ENLFEDFEEEEDDTVADEEDEADNED----------------EN 694
            .:.|    |.|::|.|     :.......|:.:..:.|||.|::.|:                |:
  Fly   138 QETV----NKSMEFRAKCQQVDKKLRQTTEKYNIQICDEEMESELENVLYEESAQQAKGVVGLED 198

  Fly   695 DNNDAATDQNLLLTSDD--------------DDVD-------DFDDEQSKHLQKPYCI-YCNKKF 737
            .:::...|...:|..||              |::|       ||..||:|...:...| .|..|
  Fly   199 FSSELLPDSEGVLDEDDFPLDAEPTQFSLSEDELDLDRDTEKDFALEQNKSCNEIISIRKCKTK- 262

  Fly   738 TSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNI 802
                  |....|..|...|            ::::..|.::.:..|...:...|..::.|:....
  Fly   263 ------EEIGKVDHGAKVY------------KVVLGEYNSLKETAPKYSLSLPKKPQLRVSPEEK 309

  Fly   803 EKLYPGRIKNPML--MCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCI 865
            .:....||:...|  :|.||.......|:::.||..|:                |...||||.|.
  Fly   310 NRRRRERIQAKPLNYVCDKCGHTFRQRSQLQMHLLRHN----------------RAKNFECPECP 358

  Fly   866 RSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTD 930
            :.|....|.:.|::..|                                     .|:|
  Fly   359 KKFYDLYTRNIHVRALH-------------------------------------KGEH------- 379

  Fly   931 VGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAAT 995

  Fly   380 ----------------------------------------------------------------- 379

  Fly   996 ATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKALSDNASSSCPINESYK 1060
                                   ||.
  Fly   380 -----------------------PFP--------------------------------------- 382

  Fly  1061 LLSTTALETSPAKGLRSNSRLHRSSIHICKLCNQTFDELGKLVKHEMELHSNTERSR-------- 1117
                                        |..||::|.......:||.::|....|.|
  Fly   383 ----------------------------CNHCNESFANASSRHRHERDVHGAGNRIRTRVKSKEE 419

  Fly  1118 WGYQHKCAICNTSYRTLTLLKFHMKRHS-NRKSQCKLCPKSFVTIAELERHTKAKHSKDKTLRCF 1181
            ...:|.|..|..||.:...|..||..|: :|..|||:|...|...:.::|| :|.|.| ..:||
  Fly   420 GSSRHYCTQCTKSYTSKKGLVLHMNFHNGSRPFQCKICQMKFADPSAMKRH-QALHDK-FPIRC- 481

  Fly  1182 MDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYL 1246
             |.|.|.|..:..|.:||                            .||.|...::|..||..|.
  Fly   482 -DICLKGFLLRSQLTKHQ----------------------------DVHTGMHPHRCEICDVHYR 517

  Fly  1247 RRGRLVTHALIIHDL------RFTTEELGNLSSLATNQARPNDLKVATPV 1290
            .|..|..|...  ||      :...||:..|.....:..:..|.:..||:
  Fly   518 HRYNLNKHKNT--DLHRDNMQKAIKEEVNGLQQAFKDIDKEMDFESQTPM 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368	4/20 (20%)
		C2H2 Zn finger	758..777	CDD:275368	1/18 (6%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1151..1172	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1180..1203	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1210..1230	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1238..1254	CDD:275368	6/15 (40%)
CG17803	NP_001303488.1	zf-AD	86..160	CDD:214871	14/77 (18%)
		COG5048	<323..528	CDD:227381	69/451 (15%)
		zf-C2H2	324..346	CDD:278523	6/21 (29%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		C2H2 Zn finger	354..375	CDD:275368	6/20 (30%)
		C2H2 Zn finger	383..401	CDD:275368	5/17 (29%)
		C2H2 Zn finger	426..446	CDD:275368	7/19 (37%)
		C2H2 Zn finger	454..474	CDD:275368	7/20 (35%)
		C2H2 Zn finger	481..501	CDD:275368	8/49 (16%)
		C2H2 Zn finger	509..528	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930