DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and CG18011

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_610559.1	Gene:	CG18011 / 36068	FlyBaseID:	FBgn0033491	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	1154	Identity:	195/1154 - (16%)
Similarity:	317/1154 - (27%)	Gaps:	494/1154 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 VNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKS 384
            :.:.||:|||.|.                 |:.:.|.|                         :.
  Fly    31 IELGLQSLLSRHY-----------------QLEVSPDP-------------------------QK 53

  Fly   385 HQLTHSNLPKFFCDQCDFYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMCLFET 449
            .||        .|:.|....:|..|:        ..::...:..|:.|||.:|:.
  Fly    54 QQL--------LCEVCVTNLIRLFDI--------DELEREREAAKDAAQGKDSKA---------- 92

  Fly   450 STVSQLRTHYKERHTVQPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNHTDIPLGI---KYPPG 511
                       |...:..||||..|. ..:|       ||:..|::.|.....|:.|   :.|..
  Fly    93 -----------EEDPIIITEVQATPP-AAKP-------AKKTVPSRPLTKVLRPVPIIPTREPSA 138

  Fly   512 VLETQAPLPQPVVHQPMPDPMQQTEPMATTSTTITESGDINVVVDATPLFYAATSN----SLLVT 572
            .:..:|.....|.    ||..:..||..|.||.       :.|..:.|...:..::    |:|:.
  Fly   139 RIRNRAAAASNVT----PDTSRSPEPPETPSTE-------DAVSKSEPKLVSKVADQEHFSVLIQ 192

  Fly   573 N--PAPVTTVEETTGTASNHAFGIFPEISEGNLPVNEAVQ-----QAPA-----NSSSVSVFGDM 625
            |  ......||:.|......               :||||     :||.     ||.:|
  Fly   193 NILDEEEAVVEDETAVKEES---------------SEAVQVTEETEAPGQIVILNSEAV------ 236

  Fly   626 QDFIDNTDVAAICTIPADGMPVVDGDDIV---IDNNNISLDFDAENLFEDFEEEEDDTVADEEDE 687
                  ||     |.|.:.:.:.:.:|::   :||..:.....:..|....||.:.|
  Fly   237 ------TD-----TNPDENVYIYEHEDVMDPNLDNVKVKPISCSSRLVAQAEESQSD-------- 282

  Fly   688 ADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQS------------------------------ 722
             |:.||.:.::... .|.:...:.|:||:..:..:
  Fly   283 -DDIDEGETSNVVL-FNFVDIKEKDEVDNIPEYLATVVKTSFEKLTFQWCTVCKHCSLKCPTFES 345

  Fly   723 --KHLQKPY-------------------------------------------CIYCNKKFTSQYK 742
              .||.|.:                                           |..|...|::..:
  Fly   346 LFSHLSKAHKSRRDVYECPIEGCNKELKGRKFLAMHLVLLHAPVAEIPIYGSCPECKLTFSNILQ 410

  Fly   743 FENHMFVH-----RGLAPYRCELCT-NLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTN 801
            :..|...|     ||...| ||:|: ...:.||........:.|..|....|      ...|.||
  Fly   411 YNKHSCAHVIKKKRGFRSY-CEMCSLEFPSWKRFNFHSQFHLEKHRPRACFV------CDYATTN 468

  Fly   802 IEKLYP----------------------------------GRIKNPMLMCAKCPFECESDSEMRK 832
            |::|:.                                  ..:.:....|::|....||...:..
  Fly   469 IDELFQHLNYSHEPVGTLFCDLCDRTFRDPSVFMEHNKSHANVSSTTYSCSECMANFESRGRLNG 533

  Fly   833 HLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGE 897
            |:.|.||                 ....|..|.|.||.:.|.:.|::: ||   |||.....|
  Fly   534 HMRAMHG-----------------SVISCELCSREFATEATYNIHMKK-HL---IIEKDVHVC-- 575

  Fly   898 AITTTMATSSSTISEPVNSVTVDGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPA 962
            :....::.|..|:...||||                  .|...|:
  Fly   576 STCGLLSDSRETLLAHVNSV------------------KTACFGS-------------------- 602

  Fly   963 VPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIM 1027
                                                                      ..|.:::
  Fly   603 ----------------------------------------------------------KIDVELL 609

  Fly  1028 RDEAQQSSPNIHDVSKALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHICKLC 1092
            ||                    :..|....||       .:.........:|.:|:..:.:|:.|
  Fly   610 RD--------------------AYVCEYCSSY-------FKEKDCLQAHRDSGVHKDGVFLCQPC 647

  Fly  1093 NQTFDELGKLVKHEM----ELHSNTERSR--------------------WG--YQHK-------- 1123
            .:.|..: ||.:|.:    :|.|::...|                    |.  |.||
  Fly   648 GKEFPHM-KLYRHHLRNYQQLRSDSTHRRLEICVYYMCDQENCTESYVNWNSLYTHKRRTHESAS 711

  Fly  1124 --------------CAICNTSYRTLTLLKFHMKR-HSNRKSQCKLCPKSFVTIAELERHTKAKHS 1173
                          |..|....|:...|..|:.| |:|....|.||..|:.:...|.:|....|.
  Fly   712 KQAEKSSKSAQEWVCQFCLKECRSKMSLSVHVARSHNNDNVTCPLCNSSYKSHDALAKHHAYWHE 776

  Fly  1174 KDKTLRCFMDGCRKTFAFKHHLIRHQKASHLS-TRYICPVCNKEEKSNVHLKNHMSVHKGEITYK 1237
            ..:...||     |....:.:...|....|.: .||.|.||.|.......::.|..:| |: :|.
  Fly   777 PIECPECF-----KIVKNRRNYDTHVNVVHSNKKRYSCSVCQKGFYHKSEMEAHQKLH-GQ-SYS 834

  Fly  1238 CPKCDRSYLRRGRLVTHALIIHDLRFTTE------ELGNLSSLATNQAR 1280
            |.:|..:...:..|..|.|..|..||..|      ..|....|.|:..|
  Fly   835 CEQCSFTTRNKKSLSVHVLGQHYKRFAFECNVCKKRFGRSQGLKTHMQR 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368	2/19 (11%)
		C2H2 Zn finger	397..418	CDD:275368	4/20 (20%)
		C2H2 Zn finger	442..460	CDD:275368	0/17 (0%)
		C2H2 Zn finger	730..750	CDD:275368	4/19 (21%)
		C2H2 Zn finger	758..777	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/24 (25%)
		C2H2 Zn finger	1124..1144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	4/22 (18%)
		C2H2 Zn finger	1210..1230	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1238..1254	CDD:275368	3/15 (20%)
CG18011	NP_610559.1	PRK14950	<98..>184	CDD:237864	24/104 (23%)
		C2H2 Zn finger	488..508	CDD:275368	0/19 (0%)
		C2H2 Zn finger	518..538	CDD:275368	5/19 (26%)
		C2H2 Zn finger	545..565	CDD:275368	7/20 (35%)
		C2H2 Zn finger	575..596	CDD:275371	7/40 (18%)
		SFP1	<682..747	CDD:227516	10/64 (16%)
		C2H2 Zn finger	754..775	CDD:275368	6/20 (30%)
		C2H2 Zn finger	780..801	CDD:275368	4/25 (16%)
		C2H2 Zn finger	809..829	CDD:275368	5/19 (26%)
		C2H2 Zn finger	864..885	CDD:275368	4/20 (20%)
		C2H2 Zn finger	891..917	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930