DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and CG10366

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_609995.1	Gene:	CG10366 / 35258	FlyBaseID:	FBgn0032814	Length:	578	Species:	Drosophila melanogaster

Alignment Length:	652	Identity:	136/652 - (20%)
Similarity:	216/652 - (33%)	Gaps:	225/652 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SPYSD--PISGAEVDYKLSCRCCLKTNVE-----YVKLDSVSVARSLDPADATEKIPLLRCLLFC 65
            :|:.|  |.|    |::..||.|.|.:|:     ::|.:....|.|::.|.|..|       .|.
  Fly    14 APHVDRNPSS----DWRQWCRLCAKDDVQGNLNVFLKNEDSGEAASMELATAIGK-------YFW 67

  Fly    66 VSADNAPELPQHICLECSKSLQVAYYFLQNALRAHEILCRKLCPKVSKRLNGTLAQEQEKPACAE 130
            |:.....|||:.||.||...:.....|.:...|..::.|         .|..|  ..||:|
  Fly    68 VNITRGEELPETICSECLSLVTSLVNFSERITRVQKLYC---------ILQST--PSQERP---- 117

  Fly   131 PVQPLKTMRHECQVCGVVLYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFE-HYVTMHNMP 194
                                |..||:.                .|..|.:.|..| |||.
  Fly   118 --------------------NLHELRS----------------KFGLLDEETQTEVHYVD----- 141

  Fly   195 LSQAEEYVKSKHLPAPK-EEEVKAVCTLEDMELLIPTVLRPE------DYVQPHPHIDNDQLRDI 252
                         ..|| :|:::.:......||..|  |.||      |..|..|..:.|: :|.
  Fly   142 -------------KKPKLDEQLEFLPEESPYELANP--LTPEEKQESVDQEQDQPTEEPDE-QDA 190

  Fly   253 DHQLAVSMDEPVPSVDSLTSTLPP---MDTPNVSIGTEYLVLPDGSLQQVNGSGVVIEYIDDSKP 314
            |::         |:.|.:..:|..   :...|.|.|:     .|||......:|   |...||:.
  Fly   191 DYE---------PNEDRVLMSLCDVYGIQEDNSSAGS-----LDGSSPSTEKAG---EDAADSEK 238

  Fly   315 NSSSN-------VNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRI------------------- 353
            ....|       .:.:||..|...:...:....:|...:...:.|:
  Fly   239 RHQCNECLRSYATSKTLQRHLRQDHGQTEPTTEQLQCPDCPKKFRLHYQLERHMKWHVPLPKRKQ 303

  Fly   354 ---------------------------KPKPAV---IGTSIH----------KH------KCKFC 372
                                       :|:|.:   .|..:|          ||      :|:.|
  Fly   304 YACSSCDKKFATSASAQQHEQYMHLDERPRPVICEQCGVGVHSMSALKEHVLKHTDYAPFECEVC 368

  Fly   373 PKTFSTVARLKSHQLTHSNLP-KFFCDQCDFYSLRSADLIQHYKMVH-----HRVDENGKTGKEQ 431
            .|.|.:..|||.|:.||.  | |:.|.:|.. .|.|...:..:::||     |:.|..|:..| :
  Fly   369 KKCFKSANRLKHHKETHD--PHKYICPECGM-QLNSRTTLNRHRLVHTDQMQHKCDYCGREFK-R 429

  Fly   432 AQGIESRV--------YSCDMCLFETSTVSQLRTHYKERHTVQPTEVQLRPSWTGEPTTTRGVAA 488
            |:.:::.:        ||||.|....:..|..|||.|:.|   |.|:..:.:..|..:..|.:..
  Fly   430 AKALKNHLILHTGLKPYSCDFCDRTFANGSNCRTHKKKSH---PEELAAQEAAGGGRSHNRNIPK 491

  Fly   489 KQQTPAKILNHTDI-----------PLGIKYPPGVLETQAPLP---QPVVHQPMPDPMQQTEPMA 539
            .:...|...|..::           ..|.|..|...:|.|..|   |....:|.|||..:....|
  Fly   492 LEALKAFTKNKDNLSPVATKQSGCFAFGKKPRPATKDTPASNPAVIQDAQPEPAPDPGGENATQA 556

  Fly   540 TT 541
            .|
  Fly   557 DT 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	23/85 (27%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		C2H2 Zn finger	397..418	CDD:275368	4/20 (20%)
		C2H2 Zn finger	442..460	CDD:275368	7/17 (41%)
		C2H2 Zn finger	730..750	CDD:275368
		C2H2 Zn finger	758..777	CDD:275368
		C2H2 Zn finger	1089..1110	CDD:275368
		C2H2 Zn finger	1124..1144	CDD:275368
		C2H2 Zn finger	1151..1172	CDD:275368
		C2H2 Zn finger	1180..1203	CDD:275368
		C2H2 Zn finger	1210..1230	CDD:275368
		C2H2 Zn finger	1238..1254	CDD:275368
CG10366	NP_609995.1	zf-AD	28..108	CDD:285071	23/95 (24%)
		PTZ00423	131..>230	CDD:240413	29/133 (22%)
		COG5048	<222..408	CDD:227381	33/191 (17%)
		C2H2 Zn finger	242..263	CDD:275368	4/20 (20%)
		C2H2 Zn finger	275..295	CDD:275368	1/19 (5%)
		C2H2 Zn finger	306..357	CDD:275368	4/50 (8%)
		C2H2 Zn finger	365..385	CDD:275368	8/19 (42%)
		C2H2 Zn finger	392..412	CDD:275368	4/20 (20%)
		zf-C2H2	418..440	CDD:278523	5/22 (23%)
		C2H2 Zn finger	420..440	CDD:275368	4/20 (20%)
		zf-H2C2_2	432..457	CDD:290200	5/24 (21%)
		C2H2 Zn finger	448..466	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100