DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and CG9932

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster

Alignment Length:	1901	Identity:	302/1901 - (15%)
Similarity:	520/1901 - (27%)	Gaps:	806/1901 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LNGTLAQEQEKP------ACAEPVQPLKTMR-HECQVCGVVLYNRLELKQHIRQ-HAEGLSYN-C 170
            :|....|:|::|      |..|.:...|..| :.|..|.....|......|:|. |.|.:..| |
  Fly    86 VNSVQQQQQQQPQQVGMDAKEEGLPQCKIKRNYSCNHCAYFTQNPRYHLTHLRDVHGEKIVINKC 150

  Fly   171 KLCSFTSLKQRTLFEHYVTMH----NMPLSQAEEYVK---SKHLPAPKEEEVKAVCTLEDMELLI 228
            |||.:.|...:.|..|...:|    .:|....:...|   |:.....:.||...|...:.:.:.:
  Fly   151 KLCLYASRHFQKLVRHMKMVHGCTDGIPSGHGQARGKRGMSREARKRRLEESVGVMGGQSLTVTV 215

  Fly   229 PTV----------LRPEDYVQPHPHIDNDQLRD-----------------IDHQLAVSMD----- 261
            |.|          |..|:.:|......|.:.|:                 .:.|:.|..|
  Fly   216 PDVPTLEQVKRELLLQEEKLQRDIQAFNQRQREEQQREQQRELELVATSAYERQMQVLRDYERQS 280

  Fly   262 ---EPVPSVDSLTSTLPPMDTPNVSIGTEYLVLPDGSLQQVNGSGVVIEYIDDSKPNSSSNVNVS 323
               .|.||..|.::| ||      |.|.|    |...|.:.:.......|....:.:.
  Fly   281 PAEPPTPSPTSGSAT-PP------SNGEE----PQNRLLKCSACEFTTLYRTQLRAHE------- 327

  Fly   324 LQNLLSSHNDPMDIDVNEL-----IVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVAR-- 381
                |:.|........::.     |.......::....|.:        ||..|  .|.|..:
  Fly   328 ----LAEHGKTKFFRCDKCSYVTHIKARFSKHVKYHSMPMI--------KCVTC--DFRTPYKWN 378

  Fly   382 LKSHQLTHSNLPKFFCDQCDFYSLRSADLIQH---YKMVHHRVDENGKTGKEQAQGIESRVYSCD 443
            |..|...|.....|.|..|||    :||:.|.   ::|.|| |...|..|....:. :::|.:.:
  Fly   379 LDRHMKNHGGAGAFKCAACDF----TADIKQSLTVHEMNHH-VPPVGNAGSIWPRR-QNKVGASE 437

  Fly   444 MCLFETSTVSQLRTHYKERHTVQPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNH--------- 499
            ||....|..::|...|...:.....:        |.......::..::.|.. |:|
  Fly   438 MCEDFLSDSAELEDQYNNNNVDDELD--------GVDDADEAMSGGEEQPLH-LHHYGKRSKYDD 493

  Fly   500 TDIPLGIKYPPGVLETQAPL--PQPVVHQPMP----------DPMQQTEPMATTSTTITESGDIN 552
            .:.|..:....|.....:.:  |.|...:.||          |.:..::....:.:::||.
  Fly   494 EEEPTDLSQKGGCSSDTSSVGTPTPRAQRTMPNLIPISKGAKDVLNLSKETNASRSSLTEI---- 554

  Fly   553 VVVDATPLFYAATSNSLL----VTNPAPVTTVEETTGTAS--NHAFGIFPEISEG----NLPVNE 607
                |:..|.....:.:|    |...:|.|||.....|.|  ........::..|    || |.:
  Fly   555 ----ASMFFNEKQISEMLDKSDVPQLSPATTVASQNSTRSQLTKKSSFMDKLKTGAQHENL-VCQ 614

  Fly   608 AVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPAD--GMPVVDGDD-IVIDNN----------N 659
            ....|...|.|: :.|       .:..|:...|..|  |:...|||| :.||.:          |
  Fly   615 CGHVAKCLSESI-IHG-------KSCHASAVIIDEDEAGLHEDDGDDRLEIDEDDEDHHSHSALN 671

  Fly   660 ISLDFD-----------------------------AENLFEDFEEEEDDTVADEE---------- 685
            :|:...                             |..:::....|..|...|.:
  Fly   672 LSVTGSTRCQHCRHRCKSSTDLMHHLKQCVEAIRCANEMYDSNSGESGDRRPDSQSLQQQAAVQQ 736

  Fly   686 ------DEADNE-----------DENDNNDAATDQNLLLTSDDDD-----------------VDD 716
                  ::|..|           |:|::|...:.......|::::                 :..
  Fly   737 QRVCIWNKATKEIIAAAAASLQQDKNNHNLVKSPTGSQAASNEENSYYGVETAPGYGEVTKKMTP 801

  Fly   717 FDDEQSKHLQKPY-CIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKH--YKTV 778
            .::..:..|:|.| |.:|:...::..:|..|:..|....|:.|.||:...|.:..:.||  .||:
  Fly   802 EEEAANSSLKKVYKCPHCSFWASTASRFHVHIVGHLNKKPFECSLCSYRSNWRWDITKHIRLKTI 866

  Fly   779 H---------------------------------------KRMPTRDMV------------QAKG 792
            .                                       |.|.:.:|.            .||.
  Fly   867 RDPSHKTAKVLMNDETGRRNYTKYNKYITLMKVTEEDGDPKLMKSGEMTPNQVASLAFLKDYAKV 931

  Fly   793 DKVSVARTNIEKLYPGR-------------IKNPML----------------------------- 815
            ..||.....:|.:.|.:             |:.|:|
  Fly   932 GSVSGQDITLEPVLPNKPNVLDDAHLADNLIRIPLLATMMNAAMAQQQHQQQQQKEHQSTMITPS 996

  Fly   816 --------------------------------------MCAKCPFECESDSEMRKHLNAHH---- 838
                                                  .|.||.|..::...:..|:..|:
  Fly   997 VTISPVKRSNQASVMQGKPSDDLITEVHQEGNEKRTVYRCRKCNFGHQNRDAVLAHVKIHYQDAS 1061

  Fly   839 --GINDGVSE--------------HANEVFIIRKLPFECPRCI---------RSFAAKTT----- 873
              ..|.|.|.              :.|:||        ...|:         .|.:|.|:
  Fly  1062 YPKSNSGNSSTSPLQVSVGGSPQFYMNKVF--------AAMCLSQTQSQSSPNSGSAGTSPAISA 1118

  Fly   874 --LSRHLQRSHLVDTIIEMQTPHC----GEAI---------TTTMATSSS--------------- 908
              |.|.:|.:.      ...||:.    |.|:         .||.|:::|
  Fly  1119 GLLQRAIQEAQ------HSPTPNASALSGLALALAGGKPQANTTKASAASILEHGEQKASQNEAS 1177

  Fly   909 --TISEPVNSVTVDGQHNEMMQTDVGAEKMTEAL--------GNGDGNEEGGTDDGTGVKAE--- 960
              :::.| |:.|.:...:...: |..|..:.:.|        ||...|....:..|.|::.:
  Fly  1178 ADSLTSP-NTTTTNSTTSRTTK-DTTARSLQDLLTSPRSARNGNHPSNANSNSVVGNGLRLDAVY 1240

  Fly   961 -----------PAVPEEELD-------PVTLDAATAVTTTAIA---------------------- 985
                       |..|...:.       |||.......|.|.:|
  Fly  1241 VASSTNNTTTPPPPPTNSVSKPNASPLPVTTTPTPISTATPLAHPLGAGNHRSSSSHHNDQNHAP 1305

  Fly   986 ---------------------------------------------------AAISAAAAATATSL 999
                                                               ||.||:|:|::|:
  Fly  1306 PSHMAGDGCHLASGLTHAHIINTNTKANPSSNSFPSSSSSSSSSSMASTSSAAGSASASASSTT- 1369

  Fly  1000 ESPVATTASSSTTLF----------PT-------------------------------PTPF--- 1020
            .||....||||.:.:          ||                               |:|:
  Fly  1370 SSPPPPAASSSASAYMAAMAPQKHVPTVAQMSHPQTRFHSHSPGSPSLLTMADGDRREPSPYRCG 1434

  Fly  1021 ------DFDYDIMR----------------------------------DEAQQSSPNIHDVSKAL 1045
                  ::.:.|.|                                  ..:.:|..:||:.|..:
  Fly  1435 HCHQVSNWKHVIQRHCRLKHSGDIRIETLERGASVSANAPPIYRPLGAGASNESQSHIHNPSNPI 1499

  Fly  1046 SD---------NASSSCPINESYKLLST---------TALETSPA---KGLRSNSRLHRSSIH-- 1087
            :.         ||:|:...|.:..||.|         |.|..|.|   ....:...:..::.:
  Fly  1500 TSNILKSGSNTNANSNINSNSAQPLLLTTKQLEQIFHTPLSASAAAVVNAANTQQDIQAAAAYWA 1564

  Fly  1088 -ICK--LCNQTFDELGKL--------------VKHEMELHSNTERSRWGYQHKCAICNTSYRTLT 1135
             .||  :.|.:.:||.:|              .:|.:....|..:|:   |.||.:|.....:.:
  Fly  1565 AACKAVVANSSAEELLQLQQNDQIEITRLPTTTEHSIGSSGNNTKSK---QQKCPVCPYISESKS 1626

  Fly  1136 LLKFHMKRHSNRKSQCKLCPKSFVTIAE--LERHTKAKHSKDKT--------------------- 1177
            .:.:|:..|...:.:|:||  :||...:  |..|.:..|.:...
  Fly  1627 QMNYHVSLHKPTQYECRLC--TFVCAKKQHLSSHMRTVHQQQMVASGAGAAAGAAGGVGGGGAAS 1689

  Fly  1178 --------------------------------------------------------LRCFMDGCR 1186
                                                                    |..:...|.
  Fly  1690 LGLDFSVALQLAAAAKQVQQLPASTPLSIDLSQIQMDAASDAELNPQQLPPEYQYKLISYCPRCP 1754

  Fly  1187 KTFAFKH------------HLIRH--QKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYK 1237
            ..||.||            ||:.|  |:.......|:|..|.........|:.|.:||......|
  Fly  1755 ARFAQKHNDERNAKQELEQHLLAHSDQEPEDQDPSYVCAYCEYRTSEETMLQLHRAVHMSHYQEK 1819

  Fly  1238 CPKCDRSYLRRGRLVTHALIIHDLRFTTEELGNLSSLATNQARPNDLK-----------VATPVG 1291
            |.:..|:            ...|:.:...:|..|:...|.....|:|.           |:|..|
  Fly  1820 CQELYRN------------CKEDVEYPAPKLLQLTGPETIWVVDNELSLQLLQQTTGGAVSTSTG 1872

  Fly  1292 LLDGRKDVSGASEENG 1307
            ..|.:..:.....|:|
  Fly  1873 GFDNQNSLLKKQLESG 1888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368	6/21 (29%)
		C2H2 Zn finger	397..418	CDD:275368	8/23 (35%)
		C2H2 Zn finger	442..460	CDD:275368	4/17 (24%)
		C2H2 Zn finger	730..750	CDD:275368	4/19 (21%)
		C2H2 Zn finger	758..777	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1089..1110	CDD:275368	7/36 (19%)
		C2H2 Zn finger	1124..1144	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1151..1172	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1180..1203	CDD:275368	9/36 (25%)
		C2H2 Zn finger	1210..1230	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1238..1254	CDD:275368	2/15 (13%)
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368	1/19 (5%)
		C2H2 Zn finger	366..386	CDD:275368	6/21 (29%)
		C2H2 Zn finger	394..414	CDD:275368	8/23 (35%)
		C2H2 Zn finger	816..836	CDD:275370	4/19 (21%)
		C2H2 Zn finger	844..862	CDD:275370	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100