DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and Zfp335

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001093956.2	Gene:	Zfp335 / 259270	RGDID:	628751	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	1428	Identity:	245/1428 - (17%)
Similarity:	398/1428 - (27%)	Gaps:	621/1428 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LDSVSVARSLDPADATEKI------P--LLRCLLFCVSADNAPELPQHICLE-------CSKSLQ 87
            |.|...|.|.|...|.:||      |  :..|:......:...|..|::.|:       .:.|:.
  Rat   117 LVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMS 181

  Fly    88 VAYYFLQNALRAHEILCRKLCPKVSKRLNGTLAQEQEKPACAEP---VQPLKTMRHECQVCGVVL 149
            .:  .|.|:|.|.|.|..      ......|..:..|:|. .||   .||...:..|..:.|:..
  Rat   182 TS--TLANSLAAIEALAD------GPTSTSTCLEPAEQPP-GEPSSLAQPPAPVVEELDLQGLEA 237

  Fly   150 YNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFEHYVTMHNMP-LSQAE-------------E 200
            ...:.:.|         .:.||:|.:.|..:.||..|....|..| |:.|.             .
  Rat   238 MMEVVVVQ---------QFKCKMCQYRSSTKATLLRHMRERHFRPALAVAAAAAGKRGRVRKWGT 293

  Fly   201 YVKSKHLPAPKEEE-------VKAVCTLED-----------------MELLIPTVLRPEDYV-QP 240
            ..|:.....|:|||       ..|:..||:                 ::...|:.|||.... :|
  Rat   294 STKTTEEEGPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTLRPRRRPGRP 358

  Fly   241 H--PHIDNDQLRDIDHQLAVSMDEPVPSVDSLTSTLPP----MDTPNVSIGTEYLVLPDGSLQQV 299
            .  |.::...|.|       .:.||:.|..|..|  ||    ::.|:.|           .|:.:
  Rat   359 RKLPRLETSDLHD-------GIGEPLVSSQSTQS--PPELQDLEAPSSS-----------DLRAL 403

  Fly   300 N--GSGVVIEYIDDSKPNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGT 362
            .  |.|:|...:..|          ..:|...|..|..|:.          |:.|.:|....:|.
  Rat   404 GKVGRGLVETGVSQS----------DAENAAPSCQDEADVP----------PRRRGRPSRRFLGK 448

  Fly   363 SIHK------------HKCKFCPKTFSTVARLKSHQLTH-SNLPKFF-CDQCDFYSLRSADLIQH 413
            ...|            :.|:.|...|.:...|:.|..:| :..|:.| |.||.:.|.|.:.|.:|
  Rat   449 KYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEH 513

  Fly   414 YKMVHHRVDENGKTGKEQAQGIESRVYSCDMC----LFETSTVSQLRTHYKERHTVQPTEVQLRP 474
              |.:|               :.|:.|.||.|    ::....:.....|.::|        :.||
  Rat   514 --MFNH---------------VGSKPYKCDECSYTSVYRKDVIRHAAVHSQDR--------KKRP 553

  Fly   475 SWTGEPTTTRGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQPMPDPMQQTEPMA 539
                :||                            |.:    :..|.||..:..|...:.|:.|.
  Rat   554 ----DPT----------------------------PKL----SSFPCPVCGRVYPMQKRLTQHMK 582

  Fly   540 TTSTTITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGTASNHAFGIFPEISEGNLP 604
            |.||
  Rat   583 THST------------------------------------------------------------- 586

  Fly   605 VNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAENL 669

  Rat   587 ----------------------------------------------------------------- 586

  Fly   670 FEDFEEEEDDTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPY-CIYC 733
                                                                    :||: |..|
  Rat   587 --------------------------------------------------------EKPHMCDKC 595

  Fly   734 NKKFTSQYKFENHMFVH-RGLA--PYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKV 795
            .|.|..:|.|:.|:..| :.:|  .::||.|..:...|:.|:.|..:
  Rat   596 GKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLS------------------ 642

  Fly   796 SVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFE 860
                         .:.:....|:.||:....:..:..|:...|   .|..            ||.
  Rat   643 -------------HVSDKPFKCSFCPYRTFREDFLLSHVAVKH---TGAK------------PFA 679

  Fly   861 CPRCIRSFAAKTTLSRHLQRSHL-----------------------VDTIIEMQTPH-------- 894
            |..|..|...|..|..|::..|.                       :..|.|::..|
  Rat   680 CEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPL 744

  Fly   895 -----------------------CGEAI-------------TTTMATSSSTISEPVNSVTVDGQH 923
                                   |.:|:             :|.|||.::          :|...
  Rat   745 SSAGPEAPQEPAPFQPPETPPLLCPDALGGATIIYQQGAEESTAMATQTA----------LDLLL 799

  Fly   924 NEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEEL-----DPVTLDAATAVTTTA 983
            |...|.::||..:..|:                ||:|..  |.||     .|.:.|....|.|..
  Rat   800 NMSAQRELGATALQVAV----------------VKSEDV--EAELTSTARQPSSEDTTPRVVTLH 846

  Fly   984 IAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFD-FDYDIMRDEAQQSSPNIHDVSKALSD 1047
            :|.:.|:.||      ||.:..:......|  .|.||. ..|.::      ::|.:       ..
  Rat   847 VAESGSSVAA------ESQLGPSDLQQIAL--PPGPFSGASYSVI------TAPPV-------EG 890

  Fly  1048 NASSSCPINESYKLLSTTALETSPAKGLRS---NSRLHRSSIHICKLCNQTFDELGKLVKHEMEL 1109
            .||:|.|   .|:       |..|.:..::   |..|..:..|.....:.|  :|     |.:||
  Rat   891 RASASGP---PYR-------EEPPGEAAQAVVVNDTLKEAGTHYIMAADGT--QL-----HHIEL 938

  Fly  1110 HSNTERS-----------RW-------------------------GYQHKCAICNTSYRTLTLLK 1138
            .::...|           :|                         |.|........:...|.||.
  Rat   939 TADGSISFPSPDTLAPGTKWPLLQCGGPPRDGPEVLSPTKTHHTGGSQGSSTPPPATSHALGLLV 1003

  Fly  1139 FH----MKRHSNRKSQCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDGCRKTFAFKHHLIRHQ 1199
            .|    ....|.:|..||:|.::|.:.||:|.|.:| |:.....:|  ..|..: |.:...:|..
  Rat  1004 PHSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRA-HAGPAAFKC--PDCPFS-ARQWPEVRAH 1064

  Fly  1200 KASHLSTR-YICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHALIIHDL 1261
            .|.|.|.| :.|..|:...|:...|:.||..|..|..:.|..|.:.:.|.|.|..|...:|.:
  Rat  1065 MAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSI 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	20/82 (24%)
		C2H2 Zn finger	369..389	CDD:275368	5/19 (26%)
		C2H2 Zn finger	397..418	CDD:275368	8/20 (40%)
		C2H2 Zn finger	442..460	CDD:275368	4/21 (19%)
		C2H2 Zn finger	730..750	CDD:275368	7/19 (37%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1124..1144	CDD:275368	4/23 (17%)
		C2H2 Zn finger	1151..1172	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1180..1203	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1210..1230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1238..1254	CDD:275368	5/15 (33%)
Zfp335	NP_001093956.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..398		24/124 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..442		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..766		1/33 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1013		6/51 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100