DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30020 and ZNF521

DIOPT Version :10

Sequence 1:NP_610627.2 Gene:CG30020 / 36156 FlyBaseID:FBgn0050020 Length:1309 Species:Drosophila melanogaster
Sequence 2:NP_056276.1 Gene:ZNF521 / 25925 HGNCID:24605 Length:1311 Species:Homo sapiens


Alignment Length:1229 Identity:242/1229 - (19%)
Similarity:377/1229 - (30%) Gaps:433/1229 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 CTLEDM----ELLIPTVLRPEDYVQPHPHIDNDQLRDIDHQLAVSMDEPVPSVDSLTSTLPPMDT 279
            |.|||.    |.| ....|||         |.::|.          ||.|.|.||.....     
Human    17 CKLEDKTEDGEAL-DCKKRPE---------DGEELE----------DEAVHSCDSCLQVF----- 56

  Fly   280 PNVSIGTEYLV----LPDGSLQQVNGSGVVIEYIDD---SKPNSSSNVNVSLQNLLSSHNDPMDI 337
            .::|..||:.:    |.||           ::..||   |.|.||.:   |......||.:..|.
Human    57 ESLSDITEHKINQCQLTDG-----------VDVEDDPTCSWPASSPS---SKDQTSPSHGEGCDF 107

  Fly   338 DVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTHSNLPKFFCDQCD- 401
            .     .||..|.:   |.|           |:||.|:||.::.||.|:.:||:...|.|..|. 
Human   108 G-----EEEGGPGL---PYP-----------CQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSR 153

  Fly   402 -FYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMCLFETSTVSQLRTHYKERHTV 465
             |...||.|  :|.|:         .||.::        |.|..|....|....|:.|.|...:.
Human   154 LFKHKRSRD--RHIKL---------HTGDKK--------YHCSECDAAFSRSDHLKIHLKTHTSN 199

  Fly   466 QPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQPMPD 530
            :|.:..:         ..||..:.    :.:..|..                      ||:...|
Human   200 KPYKCAI---------CRRGFLSS----SSLHGHMQ----------------------VHERNKD 229

  Fly   531 PMQQTEPMA------TTSTTITESG-----DINV-VVDATPLFYAATSNSLLVTNPAPVTTVEET 583
            ..|....|.      |...:..|.|     |:.. :.:..|........:.|.........||||
Human   230 GSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEET 294

  Fly   584 TGTASNHAFGIFPEISEGNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVV 648
              :..||.               |.|......:|                    |:|.::....|
Human   295 --SLMNHM---------------EQVHSGEKKNS--------------------CSICSESFHTV 322

  Fly   649 DGDDIVIDNNNISLDFDAENLFEDFEEEEDDTVADEEDEADNEDENDN---------NDAATDQN 704
                              |.|:...:       :.::.|:.|...:.:         :....|.|
Human   323 ------------------EELYSHMD-------SHQQPESCNHSNSPSLVTVGYTSVSSTTPDSN 362

  Fly   705 LLLTSDD------------------DDVDDFDDEQSKHLQKPY-CIYCNKK-FTSQYKFENH--- 746
            |.:.|..                  ....|.....||..:..| ||||||: |:|....:.|   
Human   363 LSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKT 427

  Fly   747 MFVHRGLAPYRCELC----TNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYP 807
            |.:.:....:.|:.|    .:|||:.    :|.|.||:                           
Human   428 MHLDKPEQAHICQYCLEVLPSLYNLN----EHLKQVHE--------------------------- 461

  Fly   808 GRIKNPMLMCAKCP---FECESDSE-------MRKHLNAHHGINDGVSEHANEVFIIRKLPFECP 862
              .::|.|:.:..|   ::|...||       :::|:...||..:..::.:|..|        ||
Human   462 --AQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFF--------CP 516

  Fly   863 RCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCG---EAITTTMATSSSTISEPVNSVTVDGQHN 924
            .|...|...::|..|:::.|...:.....:|..|   |.:....:.|..|.|...|||....:| 
Human   517 HCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKH- 580

  Fly   925 EMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAA-- 987
             :.:...........:.||.             |:....|   |.||.::..:.....|:..|  
Human   581 -IKENHKNIPLALNYIHNGK-------------KSRALSP---LSPVAIEQTSLKMMQAVGGAPA 628

  Fly   988 ------ISAAAAATATSLESPVATTASSSTTLFPTPT-PFDFDYDIMRDEAQQSSPNIHDVSKAL 1045
                  |.....|..|||:|......:...|:.|..| |          :..:..||    .::|
Human   629 RPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCP----------QCNKEFPN----QESL 679

  Fly  1046 SDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHI-----CKLCNQTFDELGKLVKH 1105
            ..:.:....|..:|.:..:...:.:....|:.    |...:|.     |.||.:.||....:..|
Human   680 LKHVTIHFMITSTYYICESCDKQFTSVDDLQK----HLLDMHTFVFFRCTLCQEVFDSKVSIQLH 740

  Fly  1106 EMELHSNTER------SRWGYQ--------------------HKCAICNTSYRTLTLLKFHMKRH 1144
            ....|||.::      ..|.::                    |||..|..|:.|...|:.|:..|
Human   741 LAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTH 805

  Fly  1145 SNRKSQCKLCPKSFVTIAELERHTKAKHS--KDKTLRCFMDG----------------------- 1184
            | :|..||.|.|:|..|..||:|.:.||.  :.||..|..:|                       
Human   806 S-KKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTNSQESH 869

  Fly  1185 ---------------------CRKTFAFKHHLIRHQ----------------KASHLSTRYICPV 1212
                                 |...:..:..|..||                ||..:...|.|.|
Human   870 NSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNV 934

  Fly  1213 CNKEEKSNVHLKNHMSVHKGEIT-YKCPKCDRSYLRRGRLVTHALIIHDLRFTTEELGN 1270
            |::...|...|:.||..|.|.:. |.||.|...:.....|..|. :.|.....|   ||
Human   935 CSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLLTLTEHK-VTHSKSLDT---GN 989

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30020NP_610627.2 zf-AD 25..103 CDD:214871
C2H2 Zn finger 369..389 CDD:275368 9/19 (47%)
C2H2 Zn finger 397..418 CDD:275368 8/22 (36%)
C2H2 Zn finger 442..460 CDD:275368 5/17 (29%)
C2H2 Zn finger 730..750 CDD:275368 10/23 (43%)
C2H2 Zn finger 758..777 CDD:275368 6/22 (27%)
C2H2 Zn finger 1089..1110 CDD:275368 6/20 (30%)
C2H2 Zn finger 1124..1144 CDD:275368 6/19 (32%)
C2H2 Zn finger 1151..1172 CDD:275368 9/20 (45%)
C2H2 Zn finger 1180..1203 CDD:275368 8/82 (10%)
C2H2 Zn finger 1210..1230 CDD:275368 7/19 (37%)
C2H2 Zn finger 1238..1254 CDD:275368 4/15 (27%)
ZNF521NP_056276.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..108 9/29 (31%)
C2H2 Zn finger 120..140 CDD:275368 9/19 (47%)
COG5048 128..>216 CDD:227381 27/119 (23%)
C2H2 Zn finger 148..168 CDD:275368 8/30 (27%)
zf-H2C2_2 162..185 CDD:463886 8/41 (20%)
C2H2 Zn finger 176..196 CDD:275368 6/19 (32%)
C2H2 Zn finger 204..224 CDD:275368 3/54 (6%)
C2H2 Zn finger 248..265 CDD:275368 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..397 5/47 (11%)
C2H2 Zn finger 407..428 CDD:275368 9/20 (45%)
C2H2 Zn finger 439..460 CDD:275368 7/24 (29%)
C2H2 Zn finger 479..498 CDD:275368 4/18 (22%)
C2H2 Zn finger 636..656 CDD:275368 5/19 (26%)
C2H2 Zn finger 666..686 CDD:275368 4/33 (12%)
C2H2 Zn finger 696..713 CDD:275368 1/20 (5%)
C2H2 Zn finger 724..745 CDD:275368 6/20 (30%)
C2H2 Zn finger 754..774 CDD:275368 1/19 (5%)
C2H2 Zn finger 785..805 CDD:275368 6/19 (32%)
C2H2 Zn finger 811..829 CDD:275368 9/17 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..882 0/18 (0%)
C2H2 Zn finger 888..909 CDD:275368 4/20 (20%)
C2H2 Zn finger 932..952 CDD:275368 7/19 (37%)
C2H2 Zn finger 961..981 CDD:275368 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1188
C2H2 Zn finger 1227..1247 CDD:275368
C2H2 Zn finger 1258..1279 CDD:275368
C2H2 Zn finger 1288..1307 CDD:275368
Blue background indicates that the domain is not in the aligned region.

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