DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and Zfp462

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_006537978.1	Gene:	Zfp462 / 242466	MGIID:	107690	Length:	2556	Species:	Mus musculus

Alignment Length:	1695	Identity:	329/1695 - (19%)
Similarity:	511/1695 - (30%)	Gaps:	640/1695 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPISGAEVDYKLSCRCCLKTNVEYVKL-DSVSVARSLDPADATEKIPLLRCLLFCVSADNAPELP 75
            :|:||       |.....:|.||:..: |...:|..|....||.          ..|.......|
Mouse    43 EPLSG-------SMNASNQTEVEFSSIKDEFVIAEDLPGQSATA----------LGSGGYYGHSP 90

  Fly    76 ----QHI------------CLECSKSLQVAYYFLQNALRAHEILCRKLCPKVSKRLNGTLAQEQE 124
                |||            |..|     |.|:..:|.|..|           :::::|  ||.:|
Mouse    91 GYYGQHITPNPKPTNKFFQCKFC-----VRYFRSKNLLIEH-----------TRKVHG--AQAEE 137

  Fly   125 KPACAEPVQPLKTMRHECQVCGVVLYNRLELKQHIRQHAEGLS--YNCKLCSFTSLKQRTLFEHY 187
            .|. ..||.            |.:.||       |..| ||..  ::|:.|::.|.::..:.:|.
Mouse   138 SPT-GPPVP------------GSLNYN-------IMMH-EGFGKVFSCQFCTYKSPRRARIIKHQ 181

  Fly   188 VTMHNMPLSQAEEYVKSKHLPAPKEEEVKAVCTLED--MELLIPTVLRP--EDYVQP-------- 240
            ...|...|   :|.......|||..:.:....:|:|  .||....|.|.  |..|:|
Mouse   182 KMYHKNSL---KESTAPPPAPAPLPDPLVPPVSLQDPCKELPAEVVERSILESMVKPLTKSRGNF 243

  Fly   241 --------HPHIDNDQLRDIDHQL-----------------------AVSMDEPVPSVDS--LTS 272
                    .|..:    |..||.:                       |.:.:||.|:.:|  |:.
Mouse   244 CCEWCSYQTPRRE----RWCDHMMKKHRSMVKILSSIRQQEGPNVSEAQNDNEPSPTSNSTYLSM 304

  Fly   273 TLPPMDTPNVSIGT------EYLVLPDGSLQQVNGSGVVIEYIDDSKPNSSSNVNV---SLQNLL 328
            .....:.||.::..      ..::.|:.|......|.:....:....|::|..||:   |...:.
Mouse   305 NAASREMPNANVSNFRGSMGNSIMRPNSSSTSKFSSSMSYPQMKPKSPHNSGLVNLTERSRYGMS 369

  Fly   329 SSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTHSN-- 391
            ...|...|:|.|.::.:....: .:....:..|.|:..|:          .:.|.:.||..|:
Mouse   370 DMTNSSADLDTNSMLNDSSSDE-DLNEVDSENGLSVLDHQ----------ASGLSAEQLMGSDGN 423

  Fly   392 -------------LPKFFCDQCDFYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCD 443
                         :.:|.|..|.|.::....:.:|.:.:|    .:|||.          ||.||
Mouse   424 KLLETKGIPFRRFMNRFQCPFCPFLTMHRRSISRHIENIH----LSGKTA----------VYKCD 474

  Fly   444 MCLFETSTVSQLRTHYKERH-------TVQPTEVQLRPSW-----TGEPTTTRGVAA-------K 489
            .|.|...:..:|..| |:.|       ||......|..|.     :.|.::..|..:       :
Mouse   475 ECPFTCKSSLKLGAH-KQCHTGTSDWDTVNSQSESLSSSLNEGMVSYESSSINGRKSGVMLDPLQ 538

  Fly   490 QQTPAKILNHTDIPLGIKYPPGVLETQAPLPQP------VVHQPMPDPMQQTEPMATTSTTITES 548
            ||.|.:    ...||    ||.......|||||      ..|| :|.|.||.:|
Mouse   539 QQQPPQ----PPPPL----PPPPPPPSQPLPQPPPPPLQSPHQ-VPPPTQQPQP----------- 583

  Fly   549 GDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGTAS--------NHAF-GIFPEISEG--- 601
                 ...|.||            :|...|....:|.|..        .|:| ...|:. ||
Mouse   584 -----PTQAPPL------------HPYKCTMCSYSTMTLKGLRVHQQHKHSFCDNLPKF-EGQPS 630

  Fly   602 NLPVNEAVQQAPANSSSV-----SVFG--DMQDFIDNTDVAAICTIPADGMPVVDGD--DIVIDN 657
            :||:.......|::|::|     |:.|  ...:|:...:.......|.|..||....  |.:..|
Mouse   631 SLPLENETDSHPSSSNTVKKSQTSILGLSSKNNFVAKANRKLASDFPLDLSPVKKRTRIDEIASN 695

  Fly   658 -----NNISLDFDAENLFEDFEEEEDDTVADEEDEADNEDE-------------------NDNND 698
                 |...|..||....||.||||||...:.|.|.|.|:|                   .|.::
Mouse   696 LQSKINQTKLQEDAIINVEDDEEEEDDNEVEIEVELDREEEATDPIMEVPTAFSAQQIWARDASE 760

  Fly   699 AATDQN-----------------LLLTSDDDDV-------------------------------- 714
            |..:.|                 |.|:.|::|.
Mouse   761 AQKEPNYRSITHDYTATNGAEIELTLSEDEEDYYGSSASMKDQVSNAALLNTQPAIYGTEPSNEN 825

  Fly   715 DDFDD------------------EQSKHLQK--PY-------------------CIYCNKKFTS- 739
            .||.|                  ..|.|.|:  ||                   |:.|...:|:
Mouse   826 TDFGDSGRLYYCKHCDFNNKSARSVSTHYQRMHPYIKFSFRYILDPNDHSAVYRCLECYIDYTNF 890

  Fly   740 ----QYKFENH-------MFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMV----- 788
                |:..|:|       .|.|..|. |||..|:......|.|:.||:.:|..:...:.:
Mouse   891 EDLQQHYGEHHPEAMNVLNFDHSDLI-YRCRFCSYTSPNVRSLMPHYQRMHPTVKINNAMIFSSY 954

  Fly   789 ---QAKGDKVSVARTNIEKLYPGRIKN--PMLMCAKCPF---------------------ECESD 827
               |.:|       .|.|......|.|  |..|....|.                     ||||.
Mouse   955 VVEQQEG-------LNAESQTLREILNSAPKSMATSTPVARGGGLPATFNKNTPPKTFTPECESQ 1012

  Fly   828 SEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQT 892
            .:                ...|.|.:     ::|..|  |||:          .::...::..|.
Mouse  1013 KD----------------PSVNTVVV-----YDCDVC--SFAS----------PNMHSVLVHYQK 1044

  Fly   893 PHCGEAITTTMATSSSTISEPVNSVTVD-GQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTG 956
            .|..|      ..|...|.:.:..|:|| |.....:..:||| .|:..:.|          .|:.
Mouse  1045 KHPEE------KASYFRIQKTMRMVSVDRGSALSQLSFEVGA-PMSPKMSN----------MGSP 1092

  Fly   957 VKAEPAVPEEELD-------------------------PVTLDAATAVTTTAIAAAISAAAAATA 996
            ...:|..|:..::                         |.....|..:......||:...|....
Mouse  1093 PPPQPPPPDLSIELYYCKHCSYSNRSVVGVLVHYQKRHPEIKVTAKYIRQAPPTAAMMRGAEGLQ 1157

  Fly   997 TSLESPVATTASSS-TTLFPTPTPFDF----DYD--------IMRDEAQQSSPNIHDVSKALSDN 1048
            .|...|.....:|| ....|..|...|    ||.        |...:..:......||.:..:..
Mouse  1158 DSPRPPAPLQLNSSERDCPPVETEMFFCQHCDYGNRTVKGVLIHYQKKHRDFKANADVIRQHTAT 1222

  Fly  1049 ASSSCPINESYKLLSTTALETSPAKGL-RSNSRLHRSSIHICKLCNQTFDELGKLVKHEMELH-- 1110
            ..|.|..|:  |..|...|   ||.|: |..::|....   |:.|:.|......|.||..:.|
Mouse  1223 IRSLCDRNQ--KPASCVLL---PASGMERDKTKLRALK---CRQCSYTSPYFYALRKHIKKDHPA 1279

  Fly  1111 ---SNTERSRWGY-------QHKCAICNTSYRTLT-LLKFHMKRHSN------------------ 1146
               :.|...||.:       .:.|..|..|:...: ||..:.:||..
Mouse  1280 LKATVTSIMRWAFLDGLIEAGYHCEWCIYSHMEPSGLLLHYQRRHPEHYVDYTYMATKLWAGPDP 1344

  Fly  1147 -----------RKSQCKLCPKSFVTIAELERHTKAKHS--------------KDKTLRCFMDGCR 1186
                       :..:|:.|....|:|.::..|.:|.|.              |:|      ||..
Mouse  1345 SSPTLTMSAEAKTYRCRDCVFEAVSIWDITNHYQAFHPWAMNGDESVLLDIIKEK------DGVD 1403

  Fly  1187 KTFAFKHHLI--------------------------RHQKASHL--------STRYICPVCNKEE 1217
            |.......||                          ..:|:.||        ||.|.|.|| :.|
Mouse  1404 KALLAPEELIGPVNCENSIPNPLPEQEAECPEDARLSPEKSIHLASANPAISSTPYQCTVC-QSE 1467

  Fly  1218 KSNVH-LKNH------------------MSVHKGEITYKCPKCDRSYLRRGRLVTHALIIHD-LR 1262
            .:|:| |..|                  :.::.|.: |||..|.....|...::||....|. ::
Mouse  1468 YNNLHGLLTHYGKKHPGMKVKAADFAQDIDINPGAV-YKCRHCPYINTRIHGVLTHYQKRHPAIK 1531

  Fly  1263 FTTEE 1267
            .|.|:
Mouse  1532 VTAED 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	20/97 (21%)
		C2H2 Zn finger	369..389	CDD:275368	3/19 (16%)
		C2H2 Zn finger	397..418	CDD:275368	4/20 (20%)
		C2H2 Zn finger	442..460	CDD:275368	6/17 (35%)
		C2H2 Zn finger	730..750	CDD:275368	7/31 (23%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	6/48 (13%)
		C2H2 Zn finger	1210..1230	CDD:275368	8/38 (21%)
		C2H2 Zn finger	1238..1254	CDD:275368	3/15 (20%)
Zfp462	XP_006537978.1	C2H2 Zn finger	2043..2063	CDD:275368
		zf-H2C2_5	2075..2099	CDD:404746
		C2H2 Zn finger	2077..2097	CDD:275368
		C2H2 Zn finger	2106..2127	CDD:275368
		C2H2 Zn finger	2135..2156	CDD:275368
		C2H2 Zn finger	2306..2326	CDD:275368
		C2H2 Zn finger	2352..2372	CDD:275368
		C2H2 Zn finger	2380..2401	CDD:275368
		C2H2 Zn finger	2466..2486	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100