DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG30020 and Zfp646

DIOPT Version :10

Sequence 1:NP_610627.2 Gene:CG30020 / 36156 FlyBaseID:FBgn0050020 Length:1309 Species:Drosophila melanogaster
Sequence 2:NP_766337.2 Gene:Zfp646 / 233905 MGIID:3665412 Length:1788 Species:Mus musculus


Alignment Length:1577 Identity:295/1577 - (18%)
Similarity:473/1577 - (29%) Gaps:569/1577 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 SADNAPELPQ----------HICLECSKSLQVAYYF---LQNALRAH---EILCRKLCP------ 109
            ||:|.|::.:          :.|.||.:    ||..   |.|...:|   |..| .|||      
Mouse   437 SAENTPKVDEVPTASLDHRPYKCNECGR----AYRHRGSLVNHRHSHRTGEYQC-SLCPRKYPNL 496

  Fly   110 -----------KVSKRLN--GT------LAQEQEKP-------------AC-------AEPVQPL 135
                       |.::|..  ||      :.:||..|             ||       :.|....
Mouse   497 MALRNHVRVHCKATRRSTDPGTEGSPSPVKKEQHDPVGMEAAFHGDEEHACKREEEATSNPSMAD 561

  Fly   136 KTMRHECQVCGVVLYNRLELKQHIRQHAEG------------LSYNCKLCSFTSLKQRTLFEHYV 188
            :|:...|.:||::..:...|:.|...|.||            .::.|:.|..:.....:|..|..
Mouse   562 RTVPQVCSICGMLFEDLKSLEHHSVTHREGEKSRTDSTVSPTRTFACQDCGKSYRHSGSLINHRQ 626

  Fly   189 TMHNMPLSQAEEYVKSKHLPAPKEEEVKAVCTLEDMELLIPTVLRPEDYVQPHPHIDNDQLRDID 253
            |......|..   ..:||                     ..|:...:.:::.|....|.:.:..|
Mouse   627 THQTGDFSCG---ACAKH---------------------FHTMAAMKSHLRRHSRQWNRRRQKQD 667

  Fly   254 HQLAVSMDEPVPSVDSLTSTLPP-------------MDTPNVSIG-----TEYLVLPDGSLQQV- 299
                        |.....:||||             .|:....:|     ||..:..||...|. 
Mouse   668 ------------SGTGEVATLPPGGAWTLKLENDEDPDSSQDPLGESPCETEDNLERDGDCLQAG 720

  Fly   300 -NGSGVVIE-----------------------YIDD-SKPNSSSNVNVSLQNL------------ 327
             .|:..|::                       ::|| ..|....|.......|            
Mouse   721 SRGNECVLKREEACFLGDKEGTEEGLEEREACFLDDLGTPGDECNETGFCGGLPGMDSDRKRGIC 785

  Fly   328 ---LSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTH 389
               .|||  |.|.|                    .:..:...|.|..|..:||..|.|.||:..|
Mouse   786 HSDSSSH--PADAD--------------------TVWKAAATHTCSDCGDSFSHAAGLLSHRSCH 828

  Fly   390 SNLPKFF-CDQC--DFYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMC--LFET 449
            .  |..: |..|  :|.||.:  |..|::.  ||..|..          .::.:.|.:|  :|..
Mouse   829 P--PGIYQCSLCPKEFDSLPA--LRSHFQT--HRPGEVA----------SAQPFLCCLCGMIFPG 877

  Fly   450 STVSQLRTHYKERHTVQP-TE-VQLRPSWTGEPTTTRGVAAKQQTPAKILN-------------- 498
            .|  ..|.|.::.|.... || .:.....|.|..:|.. ...|.:.|::||              
Mouse   878 RT--GYRRHLRQAHGASAMTEGSEEEEEGTAETASTHS-PPLQLSEAELLNQLQREVEALDGAGY 939

  Fly   499 -HTDIPLGIKYPP-GVLETQAPLPQPVVHQP---------MPDPMQ----QTEPMA------TTS 542
             |.....|..|.. |.||..        ||.         :|..::    .||.:|      |.:
Mouse   940 GHICGCCGQTYDDLGSLERH--------HQSQSSSNRTENVPSHLEGAGDATEMVADHGFEGTVT 996

  Fly   543 TTITESGDI-------NVVVDATPLFYAATSNSLLVTNPAPVTTVE-----ETTGTASNH----- 590
            :...|.|||       ..|.|:..:   ....|.|.::|.|....:     ...|:..||     
Mouse   997 SVSEEGGDIKSEEGVGGTVADSLCM---QAGESFLESHPRPFQCNQCGKTYRHGGSLVNHRKIHQ 1058

  Fly   591 --------AFGIFPEI---------------SEGNL-PVNEA-----VQQAPANSSSVSVFGDMQ 626
                    ....:|.:               ||..: |::||     .|.|.......:|.|.:|
Mouse  1059 TGDFICPVCSRCYPNLAAYRNHLRNHPRCKGSEPQMGPISEAGGCSEPQNAAEAGQEQAVIGQLQ 1123

  Fly   627 DFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAENLFE--DFEEEEDDTVADEEDEAD 689
            :                                   :...|.|.|  ..:||..:..|.:|:|.:
Mouse  1124 E-----------------------------------ELKVEPLEELAGVKEEVWEGTAVKEEELE 1153

  Fly   690 NEDENDNNDAATDQ----------------NLLLTSDDDDVDDFDDEQSKHLQKPYCIYCNKKFT 738
            .|.|.......|.:                :|        ::.....|:.|..   |..|:|.|:
Mouse  1154 QELETGCQTEVTSERPFSCEVCGRTYKHAGSL--------INHRQSHQTGHFG---CQACSKGFS 1207

  Fly   739 SQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQ-AKGDKVSVARTNI 802
            :....:||..:|.....:||..|...:.:::.|..|.:...:|..:|...: .:.|:        
Mouse  1208 NLMSLKNHRRIHADPRQFRCSECGKAFRLRKQLANHQRVHAERRRSRGTQKLTREDR-------- 1264

  Fly   803 EKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNA--HHGINDGVSEHANEVFIIRKLPFECPRCI 865
                              ||.|.......:|..:  :|..|...|.            :.||.|.
Mouse  1265 ------------------PFRCGQCGRTYRHAGSLMNHQCNPEASR------------YSCPFCF 1299

  Fly   866 RSFAAKTTLSRHLQRSHLVDTIIEMQT--PHCGEAITTTMA----TSSSTISEPVNSVTVDGQHN 924
            ::::.:|.|..| ||.| .|:....|:  |....|:..|:.    :...::.:.:.      :|.
Mouse  1300 KTYSNRTALKDH-QRVH-SDSQQRRQSGCPQRAAAVRCTLCGCGFSGQGSLEQHLQ------EHE 1356

  Fly   925 EMMQTDVGAEKMTEALGNG-----DGNEEG-------GTDDGTGVKAEPAVPEEELDPVTLDAAT 977
            :        .|:..|.|.|     :|:||.       |..|||.|.   .|..|...|       
Mouse  1357 D--------TKLEVASGQGGQHATEGSEENLDDWGLEGRSDGTEVL---QVEHETKRP------- 1403

  Fly   978 AVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYD--------IMRDEAQQS 1034
                           ...:.|..||..:..:.||...........|..        :::|:..:.
Mouse  1404 ---------------GGHSQSPSSPACSGGTESTQQVGKVDGSQGDRGQMNHNGAWVLQDQLTKP 1453

  Fly  1035 SPNIHD-VSKALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSS------------- 1085
            ...:.| ||:       :.|.::||.....|.....| .||..|.|:|...|             
Mouse  1454 EGKLEDTVSR-------NPCHLSESQSNGPTLRYRDS-WKGADSGSQLQPESHCCSQCGKAYCQP 1510

  Fly  1086 ------------IHICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCAICNTSYRTLTLLK 1138
                        .|||.||::.|     |.....|:|::|...|:...:...:|.:.....|.:|
Mouse  1511 DGLLNPSINGKDCHICLLCSKEF-----LNPVTTEIHNHTTAQRFACSNCSKVCESHSELATHMK 1570

  Fly  1139 FHMKRHSNRKSQCKLCPKSFVTIAELER------------------------------HTKAKHS 1173
            .|...||....|.:........:||:..                              |..|...
Mouse  1571 THAVEHSQMSGQMEKTRGPQAGMAEVGPPGPGKAQEAPSELPGDPEENGVPANGGQGIHFPAAED 1635

  Fly  1174 KDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKC 1238
            |::...|..  |.:::.....|:.|||| |....|.|.:|.|...:.:.||||...|.....|.|
Mouse  1636 KERPFCCAQ--CGRSYRHAGSLLNHQKA-HTIGLYPCSLCPKLLPNLLSLKNHSRTHTDPKRYSC 1697

  Fly  1239 PKCDRSYLRRGRLVTHALIIH---DLRFTTEEL-----GNLSSLATNQARPNDLKVAT---PVGL 1292
            ..|.:::....||..|.. :|   :..||....     ..:|.|...|....:..|::   .|..
Mouse  1698 NICGKAFRTAARLQGHGR-VHAPQEGPFTCSHCPRRFRHRISFLRHQQQHQEEWPVSSSGASVAP 1761

  Fly  1293 LDGRKDVSGASEENGQP 1309
            ...|:|.|.||..|..|
Mouse  1762 AASREDSSTASLPNPSP 1778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30020NP_610627.2 zf-AD 25..103 CDD:214871 13/51 (25%)
C2H2 Zn finger 369..389 CDD:275368 8/19 (42%)
C2H2 Zn finger 397..418 CDD:275368 7/22 (32%)
C2H2 Zn finger 442..460 CDD:275368 6/19 (32%)
C2H2 Zn finger 730..750 CDD:275368 6/19 (32%)
C2H2 Zn finger 758..777 CDD:275368 4/18 (22%)
C2H2 Zn finger 1089..1110 CDD:275368 6/20 (30%)
C2H2 Zn finger 1124..1144 CDD:275368 4/19 (21%)
C2H2 Zn finger 1151..1172 CDD:275368 4/50 (8%)
C2H2 Zn finger 1180..1203 CDD:275368 7/22 (32%)
C2H2 Zn finger 1210..1230 CDD:275368 7/19 (37%)
C2H2 Zn finger 1238..1254 CDD:275368 4/15 (27%)
Zfp646NP_766337.2 C2H2 Zn finger 10..31 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..48
C2H2 Zn finger 69..89 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..196
C2H2 Zn finger 233..253 CDD:275368
C2H2 Zn finger 260..280 CDD:275368
C2H2 Zn finger 288..308 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..360
C2H2 Zn finger 368..388 CDD:275368
C2H2 Zn finger 395..415 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 416..449 4/11 (36%)
C2H2 Zn finger 459..479 CDD:275368 7/23 (30%)
C2H2 Zn finger 486..506 CDD:275368 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..531 5/21 (24%)
C2H2 Zn finger 568..588 CDD:275368 5/19 (26%)
C2H2 Zn finger 608..628 CDD:275368 4/19 (21%)
C2H2 Zn finger 635..655 CDD:275368 3/43 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 651..712 12/72 (17%)
C2H2 Zn finger 808..828 CDD:275368 8/19 (42%)
C2H2 Zn finger 835..855 CDD:275368 7/23 (30%)
C2H2 Zn finger 868..886 CDD:275368 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 889..916 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 956..976 5/27 (19%)
C2H2 Zn finger 1037..1057 CDD:275368 3/19 (16%)
C2H2 Zn finger 1064..1084 CDD:275368 1/19 (5%)
C2H2 Zn finger 1172..1192 CDD:275368 1/27 (4%)
C2H2 Zn finger 1199..1219 CDD:275368 6/19 (32%)
C2H2 Zn finger 1227..1247 CDD:275368 4/19 (21%)
C2H2 Zn finger 1268..1285 CDD:275368 2/16 (13%)
C2H2 Zn finger 1295..1315 CDD:275368 8/20 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1386 8/48 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1398..1439 8/62 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1455..1489 10/41 (24%)
C2H2 Zn finger 1500..1518 CDD:275368 0/17 (0%)
C2H2 Zn finger 1526..1544 CDD:275368 7/22 (32%)
C2H2 Zn finger 1552..1572 CDD:275368 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1629 3/49 (6%)
C2H2 Zn finger 1642..1662 CDD:275368 7/22 (32%)
C2H2 Zn finger 1669..1689 CDD:275368 7/19 (37%)
zf-H2C2_2 1681..1706 CDD:463886 8/24 (33%)
C2H2 Zn finger 1697..1717 CDD:275368 5/20 (25%)
C2H2 Zn finger 1726..1746 CDD:275368 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1744..1788 10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.