DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30020 and Zfp92

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_033592.2	Gene:	Zfp92 / 22754	MGIID:	108094	Length:	488	Species:	Mus musculus

Alignment Length:	314	Identity:	73/314 - (23%)
Similarity:	115/314 - (36%)	Gaps:	112/314 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1027 MRDEAQQSSPNIHDVSKALSDNASSSCPINESYKLLSTTALETSP---AKGLRSNSRLHRSSI-- 1086
            :||:..:|              |:.||..|.    :.|..|.:.|   .:||..|:  .|||:
Mouse    74 IRDDGMES--------------AARSCAGNR----IKTKTLTSKPKLFGRGLLRNT--SRSSLQR 118

  Fly  1087 ----------------------HICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCAICNT 1129
                                  ::|:.|.::|.....|:||.: :||..:      .::|:.|..
Mouse   119 RPHDFRPNPIVRYQHSRIADKRYLCQQCGKSFSRSFNLIKHRI-IHSREK------PYECSECGK 176

  Fly  1130 SY-RTLTLLKFHMKRHSNRKS-QCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDG-------- 1184
            .: |:|.||: |.:.||..|. :|..|.|:|...:.|.:| :..||.:....|.|.|
Mouse   177 QFQRSLALLE-HQRIHSGDKPYECGECGKTFTRSSNLVKH-QVIHSSEMPFVCRMCGKVFRRSFA 239

  Fly  1185 ------------------CRKTFAFKHHLIRHQKASHLSTRYICPVCNKEEK--------SNVH- 1222
                              |.|.|:...:||.||:.......|||..|.|..|        ..:|
Mouse   240 LLEHTRIHSGERPFECTECGKAFSRSSNLIEHQRIHSGQKPYICKECGKAFKGVSQLIHHQLIHR 304

  Fly  1223 -------------------LKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHALI 1257
                               |..|..||:||..|:|.:|.|::.||..|..|.::
Mouse   305 GDKPFTCHEYGKAFRGLSGLSQHQRVHRGEKPYECSECGRAFGRRANLFKHQVV 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368
		C2H2 Zn finger	758..777	CDD:275368
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	10/48 (21%)
		C2H2 Zn finger	1210..1230	CDD:275368	7/47 (15%)
		C2H2 Zn finger	1238..1254	CDD:275368	6/15 (40%)
Zfp92	NP_033592.2	KRAB	14..74	CDD:214630	73/314 (23%)
		COG5048	<134..299	CDD:227381	42/173 (24%)
		C2H2 Zn finger	143..163	CDD:275368	6/20 (30%)
		C2H2 Zn finger	171..191	CDD:275368	7/20 (35%)
		C2H2 Zn finger	199..219	CDD:275368	6/20 (30%)
		C2H2 Zn finger	227..247	CDD:275368	3/19 (16%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	283..303	CDD:275368	4/19 (21%)
		C2H2 Zn finger	311..331	CDD:275368	2/19 (11%)
		zf-H2C2_2	324..348	CDD:372612	10/23 (43%)
		C2H2 Zn finger	339..359	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..408
		C2H2 Zn finger	412..432	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832239
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930