DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and Zfp521

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_663467.1	Gene:	Zfp521 / 225207	MGIID:	95459	Length:	1311	Species:	Mus musculus

Alignment Length:	1180	Identity:	237/1180 - (20%)
Similarity:	384/1180 - (32%)	Gaps:	380/1180 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 KEEEVKAVCTLEDMELLIPTVLRPEDYVQPHPHIDNDQLRDIDHQLAVSMDEPVPSVDSLTSTLP 275
            |:...|....:||.| .:....||||    ...::.|.:...|..|.|        .:||:..
Mouse    13 KDPNCKLEDKIEDGE-AVDCKKRPED----GEELEEDAVHSCDSCLQV--------FESLSDI-- 62

  Fly   276 PMDTPNVSIGTEYLV----LPDGSLQQVNGSGVVIEYIDD---SKPNSSSNVNVSLQNLLSSHND 333
                      ||:.:    |.||           ::..||   |.|.||.:   |......||.:
Mouse    63 ----------TEHKIHQCQLTDG-----------VDVEDDPSCSWPASSPS---SKDQTSPSHGE 103

  Fly   334 PMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTHSNLPKFFCD 398
            ..|..     .||..|.:   |.|           |:||.|:||.::.||.|:.:||:...|.|.
Mouse   104 GCDFG-----EEEGGPGL---PYP-----------CQFCDKSFSRLSYLKHHEQSHSDKLPFKCT 149

  Fly   399 QCD--FYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMCLFETSTVSQLRTHYKE 461
            .|.  |...||.|  :|.|:         .||.::        |.|..|....|....|:.|.|.
Mouse   150 YCSRLFKHKRSRD--RHIKL---------HTGDKK--------YHCSECDAAFSRSDHLKIHLKT 195

  Fly   462 RHTVQPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQ 526
            ..:.:|.:..:         ..||..:.    :.:..|..                      ||:
Mouse   196 HTSNKPYKCAV---------CRRGFLSS----SSLHGHMQ----------------------VHE 225

  Fly   527 PMPDPMQQTEPMA------TTSTTITESG-----DINVVV-----DATP-----LFYAATSNSLL 570
            ...|..|....|.      |...:..|.|     |:...:     :.:|     .......:.|.
Mouse   226 RNKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCMYCHELF 290

  Fly   571 VTNPAPVTTVEETTGTASNHAFGIFPEISEGNLPVNEAV-----QQAP-----ANSSSVSVFGDM 625
            |...:.:..:|:..|....::..|   .||..|.|.|..     .|.|     :||.|:...|
Mouse   291 VEETSLMNHIEQVHGGEKKNSCSI---CSESFLTVEELYSHMDSHQQPESCNHSNSPSLVTVG-- 350

  Fly   626 QDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAENLFEDFEEEEDDTVADEEDEADN 690
                 .|.|::  |.|               ::|:|:|              ..|:.   :.|..
Mouse   351 -----YTSVSS--TTP---------------DSNLSVD--------------SSTMV---EAAPP 376

  Fly   691 EDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPY-CIYCNKK-FTSQYKFENH---MFVH 750
            ..::.....|..|          ..|.....||..:..| ||||||: |:|....:.|   |.:.
Mouse   377 IPKSRGRKRAAQQ----------TSDMTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLD 431

  Fly   751 RGLAPYRCELC----TNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIK 811
            :....:.|:.|    .:|||:.    :|.|.||:                             .:
Mouse   432 KPEQAHICQYCLEVLPSLYNLN----EHLKQVHE-----------------------------AQ 463

  Fly   812 NPMLMCAKCP---FECESDSE-------MRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIR 866
            :|.|:.:..|   ::|...||       :::|:...||..:..::.:|..|        ||.|..
Mouse   464 DPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAKDSNAFF--------CPHCYM 520

  Fly   867 SFAAKTTLSRHLQRSHLVDTIIEMQTPHCG---EAITTTMATSSSTISEPVNSVTVDGQHNEMMQ 928
            .|...::|..|:::.|...:.....:|..|   |.:....:.|..|.|...|||....:|  :.:
Mouse   521 GFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKH--IKE 583

  Fly   929 TDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAA- 992
            ...........:.||.             |:....|   |.||.::..|......:....:.|:
Mouse   584 NHKNIPLALNYIHNGK-------------KSRALSP---LSPVAIEQTTLKMMQTVGGGPARASG 632

  Fly   993 -------AATATSLESPVATTASSSTTLFPTPT-PFDFDYDIMRDEAQQSSPNIHDVSKALSDNA 1049
                   .|..|||:|......:...|:.|..| |          :..:..||    .::|..:.
Mouse   633 EYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCP----------QCNKEFPN----QESLLKHV 683

  Fly  1050 SSSCPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHI-----CKLCNQTFDELGKLVKHEMEL 1109
            :....|..:|.:..:...:.:....|:.    |...:|.     |.||.:.||....:..|....
Mouse   684 TIHFMITSTYYICESCDKQFTSVDDLQK----HLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVK 744

  Fly  1110 HSNTER------SRWGYQ--------------------HKCAICNTSYRTLTLLKFHMKRHSNRK 1148
            |||.::      ..|.::                    |||..|..|:.|...|:.|:..|| :|
Mouse   745 HSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHS-KK 808

  Fly  1149 SQCKLCPKSFVTIAELERHTKAKHS--KDKTLRCFMDGC----RKTFAFKHHLIRHQKASHLS-- 1205
            ..|:.|.|:|..:..||:|.:.||.  :.||..|..:|.    :|..|....|:.:.:.||.|
Mouse   809 YNCRFCSKAFHAVILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEAELQTLLTNSQESHNSHD 873

  Fly  1206 ----------TRYICPVCNKEEKSNVHLKNHM----SVHKGEI------------TYKCPKCDRS 1244
                      ..|.|.:|.........|:||.    ::..||.            .|||..|.|:
Mouse   874 GSEEDVDSSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRT 938

  Fly  1245 YLRRGRLVTH 1254
            :.....|..|
Mouse   939 FFSENGLREH 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368	9/19 (47%)
		C2H2 Zn finger	397..418	CDD:275368	8/22 (36%)
		C2H2 Zn finger	442..460	CDD:275368	5/17 (29%)
		C2H2 Zn finger	730..750	CDD:275368	10/23 (43%)
		C2H2 Zn finger	758..777	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1151..1172	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1180..1203	CDD:275368	5/26 (19%)
		C2H2 Zn finger	1210..1230	CDD:275368	5/23 (22%)
		C2H2 Zn finger	1238..1254	CDD:275368	4/15 (27%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108		9/29 (31%)
		COG5048	<83..236	CDD:227381	50/228 (22%)
		C2H2 Zn finger	120..140	CDD:275368	9/19 (47%)
		C2H2 Zn finger	148..168	CDD:275368	8/30 (27%)
		C2H2 Zn finger	176..196	CDD:275368	6/19 (32%)
		C2H2 Zn finger	204..224	CDD:275368	3/54 (6%)
		C2H2 Zn finger	248..265	CDD:275368	3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..398		10/82 (12%)
		C2H2 Zn finger	407..428	CDD:275368	9/20 (45%)
		C2H2 Zn finger	439..460	CDD:275368	7/24 (29%)
		C2H2 Zn finger	479..498	CDD:275368	4/18 (22%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		C2H2 Zn finger	666..686	CDD:275368	4/33 (12%)
		C2H2 Zn finger	696..713	CDD:275368	1/20 (5%)
		C2H2 Zn finger	724..745	CDD:275368	6/20 (30%)
		C2H2 Zn finger	754..774	CDD:275368	1/19 (5%)
		C2H2 Zn finger	785..805	CDD:275368	6/19 (32%)
		C2H2 Zn finger	811..829	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..883		3/19 (16%)
		C2H2 Zn finger	888..909	CDD:275368	5/20 (25%)
		C2H2 Zn finger	932..952	CDD:275368	5/17 (29%)
		C2H2 Zn finger	961..981	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1136
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1258..1279	CDD:275368
		C2H2 Zn finger	1288..1307	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002621
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010