DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and lin-13

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_498678.3	Gene:	lin-13 / 176083	WormBaseID:	WBGene00003002	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	1473	Identity:	277/1473 - (18%)
Similarity:	469/1473 - (31%)	Gaps:	505/1473 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRKSPYSDPISGAEVDYKLSCRCCLKTNVEYVKLDSVSVARSLDPADATEKIPLLRCLLFCVSAD 69
            :|..||..|    ......||..|   :.||..|:..                          .|
Worm   945 QRIKPYKVP----RTSRWYSCSWC---DREYESLNQF--------------------------VD 976

  Fly    70 NAPELPQHICLECSKSLQVAYYFLQNALRAHEILCRKLCPKVSKRLNGTLAQEQEKPACAEPVQP 134
            :......|.|..|.|:     :..||..|.|  :|.:|..::..| ..||.  .:.|:|.|
Worm   977 HLTRFHTHPCPSCGKA-----FSSQNTRRTH--VCSRLFAEIKGR-GATLC--GQCPSCPE---- 1027

  Fly   135 LKTMRHECQVCGVVLYNRL-----------ELKQHIR------QHAEGLSYNCKLCSFTSLKQRT 182
                .|:.:...|.:.||.           ||....|      .|.|...|.   .|:.||:
Worm  1028 ----IHQVERIFVHMLNRHFSTIEYVLATGELLPPARDVGIRYNHGENGGYG---RSYESLR--- 1082

  Fly   183 LFEHYVTMHNMPLSQAEEYVKSKHLPAPKEEEVK-AVCTLEDMEL-LIP---------TVLRPED 236
                          ..|:.|.....|..:.::|| :...:..:|| .:|         ||..|:|
Worm  1083 --------------AIEQSVVDPRSPDYRLKQVKISALPIHGVELNRLPARDPPMGSFTVCPPKD 1133

  Fly   237 YVQPHPHIDNDQLRDIDHQLAVSMDE-PVPSVDSLTSTLPPMDTPNVSIGTEYLVLPDGSLQQVN 300
                         ::||.:|...|.| ...|.|.||
Worm  1134 -------------KNIDPRLMCYMCELTFDSYDELT----------------------------- 1156

  Fly   301 GSGVVIEYIDDSKPNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIH 365
                  .::|| .|...:|..      ..:.|.|...|:.:.:::|.:.||.        |.:.
Worm  1157 ------HHMDD-HPEKWANCP------FCAANTPTHFDLQKHLIQEHVVQIS--------GQAC- 1199

  Fly   366 KHKCKFCPK----------------TFSTVARLKSH---------QLTHS-NLPKFFCDQCDFYS 404
               |.||.:                :..|:..:||:         |.:|: .|.:|.|..|....
Worm  1200 ---CAFCQEHHRFMSSHILFRCKRVSRCTICGVKSNDPLANRVHIQRSHALTLRRFQCAYCIKVF 1261

  Fly   405 LRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCDMC---LFETSTVSQLRTHYKERHTVQ 466
            :...:..:|                |.|.| ..||||| .|   .|..|.: :...|:...|.::
Worm  1262 VSVGEYYEH----------------ECASG-GGRVYSC-TCSPNKFFNSPI-EFCDHFDSVHILR 1307

  Fly   467 PTEVQL----RPSWTG----EPTTTRGVAAKQQTPAK-ILNHTDIPLGIKYPPGVLETQAPLPQP 522
             .:.||    .||..|    ..|..|....|:||... ||.....|   |:..|.:......|.|
Worm  1308 -NKCQLCSYDAPSQDGMVKHRKTHMRSGCPKEQTKKLFILMKCLFP---KHNSGYMRFIEGGPVP 1368

  Fly   523 VVHQPMPDPMQQTE---PMATTSTTITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETT 584
            ..:|.: |..|...   .|.|.|.:..:|             ||          .||.|.:|...
Worm  1369 ASYQDV-DRSQMNYLMCNMGTVSPSCHKS-------------YA----------QAPRTLLEALE 1409

  Fly   585 GTASNHAFGIFPEISEGNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMP--V 647
            |.||:...|...::      ||...:....:||.|.:..|.:|  |:      |.:....:|  |
Worm  1410 GVASDSRSGGLQKV------VNVTTRMNEPSSSDVIMLSDDED--DD------CVVFEKAVPNGV 1460

  Fly   648 VDGDDIVIDN--NNISLDFDAENLFEDFEEEEDDTVADEEDEADNE------------------D 692
            ..|......|  ::|:.:...|.....:...:.....| ||:.|.|                  |
Worm  1461 AQGSSTSTPNPESSINCEVRVETSQAGYGGAQQPGYVD-EDDTDLEVAQGGKSPYGEPVVKEVVD 1524

  Fly   693 ENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPY-CIYCNKKFTSQYKFENHMFVHRGLAPY 756
            ||.:::.|     ::...::.........|...:|.: |..|:..|.:....|:||..||..|
Worm  1525 ENGDDELA-----VVAEVENSTGTLPSSISAGREKKFKCQKCSLAFYTNGSLESHMRDHRQDA-- 1582

  Fly   757 RCELCTNLYNMKRL-----LIKHYKTVHKRMPTRDMVQA-KGDK---------VSVARTNIEK-L 805
            ..:|||..|.:..:     |.::...|.:..|......| .||.         ::...|.|:. :
Worm  1583 GAQLCTETYGIPVVTKASWLCRNCCVVFENQPKYQKHMAIHGDTCLTCIHCSGIAFNHTAIQNHM 1647

  Fly   806 YPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGIN---------------DGVSEH-----ANE 850
            .....|.....|..|.....||..:..||:..||::               |.|.:|     .:.
Worm  1648 KSHEEKKVRYSCGTCLCTFASDLALFDHLSVAHGVSLYYFCKVCGFGSTSADSVFQHISIHNGHN 1712

  Fly   851 VFIIRKLPFECPRCIRSFAAKTTLSRHLQ----------------RSHLV--DTIIEMQTPHCGE 897
            ..::::.. .||..:.::.....|....|                ||.|:  :|::..:|.||.:
Worm  1713 YSLVQRFG-ACPAQLLNYDPTDELEFRSQILNKTIQLVSPSDCSHRSMLLQCETVVSCKTCHCTQ 1776

  Fly   898 AITTTMATSSST----------------------ISEPVNSVTVDGQHNEMMQTDVGAEKMTEAL 940
            |....||.::.:                      :|..:|      :.|.:..:..|..|
Worm  1777 AWFNYMAFNNHSEETGFPQFKNVDLANDYRRDFPLSRHLN------ERNALSMSQFGNAK----- 1830

  Fly   941 GNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLE----S 1001
             :|..|...|       :|:|                  ........:....||..:||:    |
Worm  1831 -HGSANHSHG-------QAQP------------------NKRTFRHEVPYRTAAPRSSLQTNGSS 1869

  Fly  1002 PVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKALSDN---------ASSSCPINE 1057
            ..:.|.:....:.|:| |...:..:.|...||:.|....::.:..:|         .::.|...:
Worm  1870 MGSVTTNGGRVVRPSP-PNSMNVTLRRAPPQQAPPRRIVIANSAPNNTNVLRNHVAVTTKCQFKD 1933

  Fly  1058 SYKLLSTTALETSPAKGLRSNSRLHRSSIH------ICKLCNQTFDELGKLVKHEMELH------ 1110
            ..|:|.:           ..:.:||  |:|      .|:.|..:......|..|.:::|
Worm  1934 CDKVLHS-----------EFDRQLH--SMHSSNSSWFCRQCGHSPKSEIDLFLHYIQVHLKPAYD 1985

  Fly  1111 ---SNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKSQCKLCPKSFVTIAELERHTKAKH 1172
               ||:.:|. .:..||.|     |:.|..:|.             .||:|      |:|.:..|
Worm  1986 KHQSNSFKSN-VFHLKCPI-----RSCTSPEFQ-------------SPKAF------EKHMRTAH 2025

  Fly  1173 SKDKTLR--CFMDGCRKTFAFKHHLIRH--QKASHLSTR----YICPVCN--------KEEKSNV 1221
            :.:....  |    |...||.|...::|  :.||.|.:.    ..||:|.        |:..::.
Worm  2026 AAELPFEASC----CDARFASKALCVKHDQEHASFLDSNGTDASCCPICGSLSMWSLPKDPHTDC 2086

  Fly  1222 HLKNHMSVHKGEITYKCPKCDRSY---LRRGRLVTHALIIHDL 1261
             |::|:..|..:....|.:|.:.:   :.:.:::.|.|..|.:
Worm  2087 -LQSHIIRHGLDYRSSCRQCLKQFPADVNQDQVIAHILDTHGM 2128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	15/80 (19%)
		C2H2 Zn finger	369..389	CDD:275368	7/44 (16%)
		C2H2 Zn finger	397..418	CDD:275368	3/20 (15%)
		C2H2 Zn finger	442..460	CDD:275368	5/20 (25%)
		C2H2 Zn finger	730..750	CDD:275368	6/19 (32%)
		C2H2 Zn finger	758..777	CDD:275368	5/23 (22%)
		C2H2 Zn finger	1089..1110	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1124..1144	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1151..1172	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1180..1203	CDD:275368	7/24 (29%)
		C2H2 Zn finger	1210..1230	CDD:275368	6/27 (22%)
		C2H2 Zn finger	1238..1254	CDD:275368	2/18 (11%)
lin-13	NP_498678.3	C2H2 Zn finger	961..982	CDD:275368	6/49 (12%)
lin-13	NP_498678.3	C2H2 Zn finger	986..1003	CDD:275368	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100