DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30020 and ZNF497

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001193938.1	Gene:	ZNF497 / 162968	HGNCID:	23714	Length:	498	Species:	Homo sapiens

Alignment Length:	531	Identity:	109/531 - (20%)
Similarity:	167/531 - (31%)	Gaps:	184/531 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   730 CIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDK 794
            |..|.|.|:.......|..||.|..||.|..|...:.....|.:|.: :|..
Human   108 CGECGKAFSQGSYLLQHRRVHTGEKPYTCPECGKAFAWSSNLSQHQR-IHSG------------- 158

  Fly   795 VSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPF 859
                    ||.|         .|.:|.....:.|::..|...|.|:.                ||
Human   159 --------EKPY---------ACRECGKAFRAHSQLIHHQETHSGLK----------------PF 190

  Fly   860 ECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHN 924
            .||.|.:||...|||.:| :|:|..:...|  .|.||:|.:.             ||..:  :|.
Human   191 RCPDCGKSFGRSTTLVQH-RRTHTGEKPYE--CPECGKAFSW-------------NSNFL--EHR 237

  Fly   925 EMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAIS 989
            .:                           .||.:....
Human   238 RV---------------------------HTGARPHAC--------------------------- 248

  Fly   990 AAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRD--EAQQSSPNIHDVSKALSDNASSS 1052
                                                  ||  :|...|.|:.:..|..:.....:
Human   249 --------------------------------------RDCGKAFSQSSNLAEHLKIHAGARPHA 275

  Fly  1053 CPINESYKLLSTTALETSPAKGLRSNSRLHRSSIHI-CKLCNQTFDELGKLVKHEMELHSNTERS 1116
            ||  :..|.....|       |||.:.|.|.|.... |..|.:.|.|..:|::|        :|:
Human   276 CP--DCGKAFVRVA-------GLRQHRRTHSSEKPFPCAECGKAFRESSQLLQH--------QRT 323

  Fly  1117 RWGYQ-HKCAICNTSYRTLTLLKFHMKRHSNRKSQ-CKLCPKSFVTIAELERHTKAKHSKDKTLR 1179
            ..|.: .:||.|..::...:.|..|.:.|:..|.. |..|.|:|...:.|..|.:. ||..|...
Human   324 HTGERPFECAECGQAFVMGSYLAEHRRVHTGEKPHACAQCGKAFSQRSNLLSHRRT-HSGAKPFA 387

  Fly  1180 CFMDGCRKTFAFKHHLIRHQKASHLSTR-YICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDR 1243
            |  ..|.|.|.....| .|.:.||...| :.|..|.|..:.:..|:.|..:|.||..:.|..|.:
Human   388 C--ADCGKAFRGSSGL-AHHRLSHTGERPFACAECGKAFRGSSELRQHQRLHSGERPFVCAHCSK 449

  Fly  1244 SYLRRGRLVTH 1254
            :::|:..|::|
Human   450 AFVRKSELLSH 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368	5/19 (26%)
		C2H2 Zn finger	758..777	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1210..1230	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1238..1254	CDD:275368	4/15 (27%)
ZNF497	NP_001193938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..104
		COG5048	107..492	CDD:227381	109/531 (21%)
		C2H2 Zn finger	108..128	CDD:275368	5/19 (26%)
		zf-H2C2_2	120..144	CDD:290200	8/23 (35%)
		C2H2 Zn finger	136..156	CDD:275368	4/20 (20%)
		zf-H2C2_2	148..171	CDD:290200	8/53 (15%)
		C2H2 Zn finger	164..184	CDD:275368	4/19 (21%)
		zf-C2H2	190..212	CDD:278523	11/22 (50%)
		C2H2 Zn finger	192..212	CDD:275368	10/20 (50%)
		zf-H2C2_2	205..228	CDD:290200	9/25 (36%)
		C2H2 Zn finger	220..240	CDD:275368	7/61 (11%)
		C2H2 Zn finger	248..268	CDD:275368	6/84 (7%)
		C2H2 Zn finger	276..296	CDD:275368	8/28 (29%)
		zf-H2C2_2	289..311	CDD:290200	7/21 (33%)
		C2H2 Zn finger	304..324	CDD:275368	7/27 (26%)
		zf-H2C2_2	317..340	CDD:290200	7/30 (23%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	344..369	CDD:290200	8/24 (33%)
		C2H2 Zn finger	360..380	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	6/22 (27%)
		C2H2 Zn finger	416..436	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..453	CDD:290200	7/24 (29%)
		C2H2 Zn finger	444..464	CDD:275368	5/17 (29%)
		zf-H2C2_2	456..481	CDD:290200	2/5 (40%)
		C2H2 Zn finger	472..492	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930