DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30020 and ZNF513

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_653232.3	Gene:	ZNF513 / 130557	HGNCID:	26498	Length:	541	Species:	Homo sapiens

Alignment Length:	678	Identity:	136/678 - (20%)
Similarity:	201/678 - (29%)	Gaps:	240/678 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 LPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAE 667
            :|..:.....|.....|.|  |.:|.:|                  :|...::..:::.|..|.|
Human     1 MPRRKQSHPQPVKCEGVKV--DTEDSLD------------------EGPGALVLESDLLLGQDLE 45

  Fly   668 NLFEDFEEEED-DTVADEEDEADNEDENDNNDAATDQNLLLTSD----------DDDVDD---FD 718
              ||:.||||: |..:|:....:.:.|.|:..|.......|:.|          :.:|::   ..
Human    46 --FEEEEEEEEGDGNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPARGP 108

  Fly   719 DEQSKHLQKPYCIYCNKKFTSQYKFENHMFVHRGLAP------------------YRCELCTNLY 765
            .|.......|.|..|...              .|..|                  |.|.|||
Human   109 GEARGERPGPACQLCGGP--------------TGEGPCCGAGGPGGGPLLPPRLLYSCRLCT--- 156

  Fly   766 NMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEM 830
                 .:.||.:..|    |.|....|:|            |.|       |.:||:.......:
Human   157 -----FVSHYSSHLK----RHMQTHSGEK------------PFR-------CGRCPYASAQLVNL 193

  Fly   831 RKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTTLSRHLQRSHLVDTIIEMQTPHC 895
            .:|...|.|                :.|:.||.|..:.::...|.|| ||:|....  ....|.|
Human   194 TRHTRTHTG----------------EKPYRCPHCPFACSSLGNLRRH-QRTHAGPP--TPPCPTC 239

  Fly   896 GEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTDV------GAEKMTEALGNGDGNEEGGTDDG 954
            |....|.......:.:|...:|. ....:.::..|:      |........|...|..||..  |
Human   240 GFRCCTPRPARPPSPTEQEGAVP-RRPEDALLLPDLSLHVPPGGASFLPDCGQLRGEGEGLC--G 301

  Fly   955 TGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESPVATTASSSTTLFPTPTP 1019
            ||  :|| :| |.|.|.|.............:.:.||.....
Human   302 TG--SEP-LP-ELLFPWTCRGCGQELEEGEGSRLGAAMCGRC----------------------- 339

  Fly  1020 FDFDYDIMRDEAQQSSPNIHDVSKALSDNASSSCPINESYKLLSTTALETSPAKGLRSNSRLHRS 1084
                   ||.||               ...:|..|...|.|..:
Human   340 -------MRGEA---------------GGGASGGPQGPSDKGFA--------------------- 361

  Fly  1085 SIHICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNRKS 1149
                |.||.........|.:| |:.||..:..|      ||.|..:...|..||.|.:.|:..|.
Human   362 ----CSLCPFATHYPNHLARH-MKTHSGEKPFR------CARCPYASAHLDNLKRHQRVHTGEKP 415

  Fly  1150 -QCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDGCRKTFAFKHHLIRHQKASHLSTRYICPVC 1213
             :|.|||.:...:|.|:||.:. ||.||..|                              |.:|
Human   416 YKCPLCPYACGNLANLKRHGRI-HSGDKPFR------------------------------CSLC 449

  Fly  1214 NKEEKSNVHLKNHMSVHKGEITYKCPKC 1241
            |.....:::||.||..|.||..::|..|
Human   450 NYSCNQSMNLKRHMLRHTGEKPFRCATC 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..418	CDD:275368
		C2H2 Zn finger	442..460	CDD:275368
		C2H2 Zn finger	730..750	CDD:275368	2/19 (11%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1124..1144	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1151..1172	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1180..1203	CDD:275368	0/22 (0%)
		C2H2 Zn finger	1210..1230	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1238..1254	CDD:275368	2/4 (50%)
ZNF513	NP_653232.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		26/138 (19%)
		C2H2 Zn finger	152..172	CDD:275368	9/31 (29%)
		COG5048	176..>228	CDD:227381	18/87 (21%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		zf-H2C2_2	192..217	CDD:316026	7/40 (18%)
		C2H2 Zn finger	208..228	CDD:275368	8/20 (40%)
		C2H2 Zn finger	362..382	CDD:275368	6/20 (30%)
		COG5048	<372..>450	CDD:227381	29/115 (25%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		COG5048	414..>487	CDD:227381	26/95 (27%)
		C2H2 Zn finger	418..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..493	CDD:275368	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100