DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and znf335

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_005167155.1	Gene:	znf335 / 100148891	ZFINID:	ZDB-GENE-130530-814	Length:	1534	Species:	Danio rerio

Alignment Length:	1581	Identity:	294/1581 - (18%)
Similarity:	487/1581 - (30%)	Gaps:	578/1581 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TNVEYVKL-DSVSVARSLDPADATEKIPLLRCLLFCVSADNAPELPQHICLECSKSLQVAYYF-- 92
            |:|..|.| ||.|||:|                   .|..:...:.|.:.:  |:|:||..:.
Zfish    74 TDVRRVHLPDSSSVAQS-------------------TSVSSVSTVTQSVLV--SESVQVLVHSSA 117

  Fly    93 ------------------LQNALRAHEILCRKLCPKVSKRLNGTLAQEQEKPACAEPVQPLKTMR 139
                              |.:|:  .:|:...:.|.:   :||.:|....:...||..|.|....
Zfish   118 VSEGGMMVSDSTASTSSDLGSAI--DKIIESTIGPDI---MNGCIAVTSAEDGSAETTQYLILQG 177

  Fly   140 HE------CQVCGVVLYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFEHYVTMHNMPLSQA 198
            .:      .|:....|.:|:.    |...|:|.:..|       |.|..|.|:  ...||...|.
Zfish   178 PDDGAPMVAQMSSSALSSRIA----IEALADGPTSTC-------LDQPDLSEN--PQGNMEPDQP 229

  Fly   199 EEYVKSKHLPAPKEEEVKAVCTLEDMELLIPTVLRPEDYVQPHPHIDNDQLRDIDHQLAVSMDEP 263
            ......:|........                  || |..|...:||.||.|:..: :..|.||
Zfish   230 GHSGYREHDDGSSSSS------------------RP-DQPQHSQYIDPDQTREARY-IQCSADE- 273

  Fly   264 VPSVDSLTSTLPPMDTPNVSIGTEY-LVLPDGSLQQ----------------VNGSGVVIEYID- 310
                        |..||..|..|:| |...:..||:                ...|..|:|..|
Zfish   274 ------------PDQTPRHSGVTDYNLADSEEPLQRYAAECSGTNDIPQRSSYRSSRYVVECSDG 326

  Fly   311 --------DSKPNSSSNVNVSLQNLLSSHNDPMDIDVNEL---IVEE----MMPQIRIKPKPAVI 360
                    :.:|..|..::       ||.:|...:..:|.   .:||    .|||..:......:
Zfish   327 YLEYEADGEDRPQHSRYID-------SSMDDREHVSASEQEGGALEEPQHSYMPQESLYADEGAV 384

  Fly   361 GTSIHKHKCKFCPKTFSTVARLKSHQLTHS-NLPKFFCDQCDFYSLRSADLIQHYKMVHHRVDEN 424
            ..|:           ..||....:.|:..| |||..:......||..:...:....:    |||.
Zfish   385 QHSL-----------ADTVGSQLNDQMDCSDNLPGPYISSSGTYSTNTEPEVVESGV----VDEP 434

  Fly   425 GKTGKEQAQGIESRV-------YSCDMCLFETSTVSQLRTHYKERHTVQPTEVQLRPSWTGEPTT 482
            |:.....|: :|..:       :.|.||.:::.:...|..|.:::|.              :|..
Zfish   435 GQRTPNMAE-LEEMMEVVIVQQFKCKMCPYKSVSKDTLINHMRDKHF--------------KPAG 484

  Fly   483 TRGVAAKQQTPAKILNHTDIPLGIKY---PPGVLETQAPLPQPVVHQPMPDPMQQTEPMATTSTT 544
            :|...|        ::|.|.|...|.   .|...|::|.....|..:..|   ::.|.....:..
Zfish   485 SRSGGA--------VSHADGPGQRKRGRGRPRKSESKAGAVVVVKKEEQP---EEEEDDIVDAGA 538

  Fly   545 ITESGDINVVVDATPLFYAATSNSLLVTN--PAPVTTVEETTGTASNHAFGIFPEISEGN----L 603
            :.:.||    .|..|....|.|. |.|::  |.|..:......|:...     |....|.    |
Zfish   539 LDDQGD----SDYKPADEEARSR-LAVSHFTPPPSCSSSSPASTSRKR-----PRRMVGPPRKFL 593

  Fly   604 PVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAEN 668
            |.:|    :||..|..          :||:         |.....:.....:||.:.|
Zfish   594 PDSE----SPAAPSET----------NNTE---------DPQAPEEASSSGLDNGSSS------- 628

  Fly   669 LFEDFEEEEDDTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQ----SKHLQKPY 729
             |.:..|.|...   .:.:::|.|.:.|            :..||::....::    .:.|||.|
Zfish   629 -FSNGTEVEPGV---SQSDSENRDPSSN------------TSPDDLEFLPKKRGRPSKRFLQKKY 677

  Fly   730 ---------------------CIYCNKKFTSQ-----------------YK-------------F 743
                                 |..|..:|.||                 ||             .
Zfish   678 KKYMNRNKYYRSLKPLLRPHNCWICGSRFLSQEDLKFHVDSHEGNDPERYKCLQCSYRCKRWSSL 742

  Fly   744 ENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMV---QAKGDKVSVARTN---- 801
            :.|||.|.|..||:||:|            .|.:|:|:..||...   ::|..|:.|:..|
Zfish   743 KEHMFNHEGTKPYKCEMC------------DYTSVYKKDVTRHSAVHNKSKSRKIDVSCVNPSQV 795

  Fly   802 ----------IEKLYP--GRIKNPML--------MCAKCPFECESDSEMRKHLNAH--------- 837
                      ..::||  .|:...|.        ||.||....:.....:.||..|
Zfish   796 SKVSEFPCPICSRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQNCGNSLF 860

  Fly   838 -------------HGINDGVSEHAN---------------EVFIIRKL--------PFECPRCIR 866
                         |.:|..:| |.|               |.|::..:        ||.|..|..
Zfish   861 KCEFCDYTCNDKKHLLNHQLS-HTNDKPFKCEECKYSTSKEDFLVSHIAIKHTGEKPFSCEMCHF 924

  Fly   867 SFAAKTTLSRHLQ-----------RSHLVDTIIEMQTP------------------HCGEAITTT 902
            :...:..|..|:|           |:|..:.:...|||                  ..|..:|..
Zfish   925 TTRHRKNLRLHVQCRHPETFEEWSRTHPDEPVRRRQTPVFTVEQIEELRLQHETQEFQGTIVTVD 989

  Fly   903 MATSSSTISEPVNSVTVDGQHN------EMMQTDVGAEKMTE---------------------AL 940
            ..|..:..|....||:.|...|      :...:|:.|:...:                     ||
Zfish   990 PLTLQTMESIGNTSVSQDALGNTTIIYEQAQNSDLSAQNALDLLLNMSNARELQVAVLKTDGKAL 1054

  Fly   941 GNGDGNEEGGTDDGTGVKAEPAVP---EEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESP 1002
            ..|..:..|...:|:.::.:..|.   .|..|.:..:|....|     .|:.....|.|..:|..
Zfish  1055 ETGSWSGSGSGSEGSSLQPQKIVTFHVSENGDTLVQEAFETAT-----GAVEQEETAVAQEVEQE 1114

  Fly  1003 VATT---ASSSTTLFPTPTPFDFDYDIMRDEAQQSS----------PNIHDVSKALSDNASSSCP 1054
            ||..   |...|           |:.::...:::::          |.:.:||   ::..|.|.|
Zfish  1115 VAQIGIGAYEGT-----------DFSVVEQTSEETTHSSLEEPSAEPQVMEVS---TEPLSISTP 1165

  Fly  1055 INESYKLLSTTALETSPAKGLRSNSRLHRSSIHICKLCNQTFDELGKLVKHEMELHSNTERSRWG 1119
            :.|:.:....::       ||...                        |..::||.|....|
Zfish  1166 LKENKEKFYVSS-------GLTDG------------------------VLQQVELSSEAPAS--- 1196

  Fly  1120 YQHKCAICNTSYRTLTLLKFHMKRHSNRKSQCKLCPKSFVTIAELERHTKAKHSKDKTLRCFMDG 1184
                        ..|:... |.::.:.::..|::|.::|...:::|.|.:| |...||.:|  ..
Zfish  1197 ------------PPLSPSP-HSQQLNTKRFSCRICMEAFHGRSDMENHKRA-HIDPKTFKC--PD 1245

  Fly  1185 CR---------KTFAFKHHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPK 1240
            |.         ||....|..:|..|         |..|:...|:...|:.||..|..|..|.|..
Zfish  1246 CDFTAPSWPEVKTHMALHAYLRPHK---------CTSCSFASKNKKDLRRHMMTHTNEKPYSCQV 1301

  Fly  1241 CDRSYLRRGRLVTHALIIHD------------------LRFTTEELGNLSSLATNQA--RPNDLK 1285
            |.:.:.|.|.|..|...:|.                  :....|.|..|.:|...||  .|..|:
Zfish  1302 CGQRFNRNGHLKFHMERLHTQEPSPRKARSVPSQQTIIINSDEEALATLQNLQAGQAVISPERLQ 1366

  Fly  1286 VATPVGLLDGRKDVSGASEEN 1306
            .|.      |::.:..|.:::
Zfish  1367 QAL------GQEHIIVAQDQS 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	19/95 (20%)
		C2H2 Zn finger	369..389	CDD:275368	3/19 (16%)
		C2H2 Zn finger	397..418	CDD:275368	2/20 (10%)
		C2H2 Zn finger	442..460	CDD:275368	5/17 (29%)
		C2H2 Zn finger	730..750	CDD:275368	10/49 (20%)
		C2H2 Zn finger	758..777	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1089..1110	CDD:275368	2/20 (10%)
		C2H2 Zn finger	1124..1144	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1180..1203	CDD:275368	7/31 (23%)
		C2H2 Zn finger	1210..1230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1238..1254	CDD:275368	5/15 (33%)
znf335	XP_005167155.1	COG5048	<592..838	CDD:227381	58/303 (19%)
		C2H2 Zn finger	699..719	CDD:275368	5/19 (26%)
		C2H2 Zn finger	729..749	CDD:275368	3/19 (16%)
		zf-H2C2_2	741..766	CDD:290200	11/36 (31%)
		C2H2 Zn finger	803..823	CDD:275368	4/19 (21%)
		zf-H2C2_2	816..839	CDD:290200	5/22 (23%)
		zf-C2H2	829..851	CDD:278523	6/21 (29%)
		C2H2 Zn finger	831..851	CDD:275368	5/19 (26%)
		C2H2 Zn finger	862..882	CDD:275368	3/20 (15%)
		zf-H2C2_2	874..898	CDD:290200	5/24 (21%)
		C2H2 Zn finger	890..911	CDD:275368	2/20 (10%)
		C2H2 Zn finger	919..936	CDD:275368	3/16 (19%)
		C2H2 Zn finger	1215..1235	CDD:275370	6/20 (30%)
		C2H2 Zn finger	1243..1263	CDD:275368	4/21 (19%)
		C2H2 Zn finger	1271..1291	CDD:275368	6/19 (32%)
		zf-H2C2_2	1283..1308	CDD:290200	8/24 (33%)
		C2H2 Zn finger	1299..1320	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100