DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30020 and sall1

DIOPT Version :9

Sequence 1:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001090646.1	Gene:	sall1 / 100036618	XenbaseID:	XB-GENE-491393	Length:	1330	Species:	Xenopus tropicalis

Alignment Length:	1426	Identity:	268/1426 - (18%)
Similarity:	436/1426 - (30%)	Gaps:	523/1426 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DSVSVARSLDPADATEKIPLLRCLLFCVSADNAPELPQHICLECSKSLQVAY-YFLQN------- 95
            ||.|...:|..:..|..:|.:|.|   .:..|...:..::.:|..:|.:||. .|.|.
Frog   179 DSSSNNPTLGTSAITTSLPQVRDL---TALGNFSMINSNVIIENLQSTRVAVAQFSQEAKTKGAA 240

  Fly    96 --------------ALRAHEILCRKLCPKVSKRLNGTLAQEQEKPACAEPVQ--------PLKTM 138
                          ||:..:|....|..::..::....:|..:.|..|...|        ||.|
Frog   241 NNKLAVPALMEQLLALQQQQIHQLHLIEQIRHQILLLASQSADMPTSASGPQGALRVSATPLTT- 304

  Fly   139 RHECQVCGVVLYNRLELKQHIRQHAEGLSYNCKLCSFTSLKQRTLFEHYVTMHNMPLSQAEEYVK 203
                            |..|:.|         :|.:...|.|..            .||:.....
Frog   305 ----------------LSSHLSQ---------QLAAAAGLAQSL------------ASQSASISG 332

  Fly   204 SKHLP---APKEEEVKAVCTLE----DMELLIPTVLRPEDYVQPHPHIDNDQLRDIDHQLAVSMD 261
            .|.||   .|:...|..|.::.    :|..|..||..|          .:|::........|| :
Frog   333 MKQLPPIQLPQSNPVNTVPSISSSSPNMNALASTVTSP----------SSDKVPSSTGGSQVS-N 386

  Fly   262 EPVPSVDS----LTSTLPPMDTPNVSIGTEYLVLPD---------GSLQQVNGSGVVIEYIDDSK 313
            .|.|...|    ::|.|.|...|         :||.         |:|..:..:...:..:..||
Frog   387 PPAPVTSSPAFAISSLLSPASNP---------LLPQPAPNTTPFPGTLPSIGTTAEDLNSLRKSK 442

  Fly   314 PNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEEMMPQIRIKPKPAVIGTSIHKHKCKFCPKTFST 378
            |                                  |.:......:....:..||||:||.|.|.:
Frog   443 P----------------------------------PSVTAFETKSTSDEAFFKHKCRFCAKVFGS 473

  Fly   379 VARLKSHQLTHSNLPKFFCDQCDFYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIESRVYSCD 443
            .:.|:.|..:|                                     ||:        |.:.|:
Frog   474 DSALQIHLRSH-------------------------------------TGE--------RPFKCN 493

  Fly   444 MCLFETSTVSQLRTHYKERHTVQPTEVQLRPSWTGE-----PTTTRGVAAKQQTPAKILNHTDIP 503
            :|....||...|:.|: :||..:...:|:.|....|     ||:                 |.||
Frog   494 ICGNRFSTKGNLKVHF-QRHKEKYPHIQMNPYPVPEHLDNIPTS-----------------TGIP 540

  Fly   504 LGIKYPP-----GVLETQAPLPQPVVHQPMPDPMQQTEPMATTSTTITESGDINVVVDATPLFYA 563
            .|:..||     ..|:|:..||.......||.|     |...|.|:..::.:...:..:.|
Frog   541 YGMSIPPEKPVTNWLDTKPVLPTLTTSVGMPLP-----PTIPTLTSFIKTEEPQPIAISHP---- 596

  Fly   564 ATSNSLLVTNPAPVTTVEETTGT------ASNHAFGIFPEISEGNLPVNEAVQQAPANSSSVSVF 622
                     ..:|..:|:..|.|      .|:     .|:.:|..:|:.:..:|...||
Frog   597 ---------TASPPDSVKSETATEPLLKKTSD-----LPDEAEAAMPILDKEEQQSQNS------ 641

  Fly   623 GDMQDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFDAENL---FEDFEEE------ED 678
                |.|.|.:.:| |: |..|             :.||..|....|   .|.|:.:      .|
Frog   642 ----DCIQNLNTSA-CS-PTTG-------------SGISASFPNPLLPLMSEQFKAKFPFGGLLD 687

  Fly   679 DTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPYCIYCNKKFTSQYKF 743
            ...|.|..:.....||.:..         :||.::                |:.|.:..:.|...
Frog   688 VAPASETSKLQQLVENIDKK---------SSDPNE----------------CVICRRVLSCQSAL 727

  Fly   744 ENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPG 808
            :.|...|.|..|::|::|...:..|..|..|| :||:.||                       |.
Frog   728 KMHYRTHTGERPFKCKICGRAFTTKGNLKTHY-SVHRAMP-----------------------PL 768

  Fly   809 RIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRKLPFECPRCIRSFAAKTT 873
            |:::                                               .||.|.:.|.....
Frog   769 RVQH-----------------------------------------------SCPICQKKFTNAVV 786

  Fly   874 LSRHLQRSHLVDTIIEMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTDVGA--EKM 936
            |.:|::.             |.|..|..|....|               :.:.|::|.|:  ||.
Frog   787 LQQHIRM-------------HMGGQIPNTPIAES---------------YPDSMESDTGSFDEKT 823

  Fly   937 TEALGN-GDGNEEGGTDDGT------------GVKAEPAVPEEELDPVT-LDAATAVTTTAIAAA 987
            .:.|.| .|.|.|...|...            .:.:.|..|  |:..:| |:....:....:|..
Frog   824 IDDLDNFSDENMEDCPDSSVPDTPKSVDASQDSLSSSPLPP--EVSSITALENQMKLINAGLAEQ 886

  Fly   988 ISAAAAATAT-SLESPVATTASSS------TTLFPTPTPFDFDYDIMRDEAQQSSPNIHDVSKAL 1045
            :.|:..:|.. |:|....|..|||      :....:|.            |.:|:.::|.:|.:.
Frog   887 LQASLKSTENGSIEGDGMTNDSSSLGGDMESQSAGSPA------------ASESTYSMHALSPSN 939

  Fly  1046 SDNASSSCP-----INESYKLLSTTALETSPAKG-----LRSNSRLHRSSIH------------- 1087
            |.|.....|     |:.:..|..|:.|..:||.|     ..||:.......|
Frog   940 STNDYLKSPNTDEKIHRALSLDPTSGLSPTPANGGALDLTSSNTDKVIKDEHLGVLFPFRERGKY 1004

  Fly  1088 ---ICKLCNQTFDELGKLVKHEMELH--SNTERSRWGYQHKCAICNTSYRTLTLLKFHMKRHSNR 1147
               ||.:|.:||     ..:..:::|  |:|:...:    .|.:||..:.|...||.||..|..|
Frog  1005 KNTICDICGKTF-----ACQSALDIHYRSHTKERPF----ICTVCNRGFSTKGNLKQHMLTHQMR 1060

  Fly  1148 KSQCKLCPKS----------------FVTIAELE----RHTKAKHSKDKTLRCFMDGCRKTFAFK 1192
            ....:|...|                ..||.:.|    .|..::..|::.......|...:.|..
Frog  1061 DLPSQLFEPSSSMTPTPTVPSTPTNPLATIIKTEFNGFMHGSSQDIKEQPTNIVSSGSLPSSATS 1125

  Fly  1193 HHLIRHQKASHLSTRYICPVCNKEEKSNVHLKNHMSVHKGEITYKCPKCDRSYLRRGRLVTHALI 1257
            ..|: ...|.....::.|..|.|...|:..|:.|...|.||..:.|..|.|::..:|.|..|
Frog  1126 PVLL-PALARRTPKQHYCNACGKSFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVH--- 1186

  Fly  1258 IHDLRFTTEELGNLSSLATNQARPNDLKVATPVGLLDG---------RKDVSGASEENGQP 1309
                      :|.....:|...|...|.|..|:..|.|         :||: |....|..|
Frog  1187 ----------MGTHMWNSTPARRGRRLSVDGPMAFLGGNPVKFPEMFQKDL-GTRAGNADP 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	18/88 (20%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..418	CDD:275368	0/20 (0%)
		C2H2 Zn finger	442..460	CDD:275368	6/17 (35%)
		C2H2 Zn finger	730..750	CDD:275368	4/19 (21%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1124..1144	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1151..1172	CDD:275368	6/40 (15%)
		C2H2 Zn finger	1180..1203	CDD:275368	4/22 (18%)
		C2H2 Zn finger	1210..1230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1238..1254	CDD:275368	5/15 (33%)
sall1	NP_001090646.1	PHA03247	<278..683	CDD:223021	112/607 (18%)
		PRK10856	<326..>438	CDD:236776	26/131 (20%)
		SUF4-like	461..543	CDD:411020	30/144 (21%)
		C2H2 Zn finger	464..485	CDD:411020	8/57 (14%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:411020	6/20 (30%)
		C2H2 Zn finger	492..512	CDD:275368	6/20 (30%)
		C2H2 Zn finger	714..734	CDD:275368	4/19 (21%)
		zf-H2C2_2	726..751	CDD:404364	6/24 (25%)
		C2H2 Zn finger	742..762	CDD:275368	6/20 (30%)
		zf-C2H2	772..794	CDD:395048	6/81 (7%)
		C2H2 Zn finger	774..794	CDD:275368	6/32 (19%)
		C2H2 Zn finger	1009..1029	CDD:275370	5/24 (21%)
		SUF4-like	1012..>1056	CDD:411020	14/52 (27%)
		C2H2 Zn finger	1012..1030	CDD:411020	5/22 (23%)
		zf-C2H2	1035..1057	CDD:395048	8/25 (32%)
		C2H2 Zn finger	1037..1057	CDD:275370	8/19 (42%)
		C2H2 Zn finger	1037..1056	CDD:411020	8/18 (44%)
		SUF4-like	1140..>1187	CDD:411020	15/59 (25%)
		C2H2 Zn finger	1142..1163	CDD:411020	6/20 (30%)
		C2H2 Zn finger	1142..1162	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1170..1190	CDD:275368	7/32 (22%)
		C2H2 Zn finger	1170..1187	CDD:411020	6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000