DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nclb and AT4G35370

DIOPT Version :9

Sequence 1:	NP_610623.1	Gene:	nclb / 36150	FlyBaseID:	FBgn0263510	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_195263.4	Gene:	AT4G35370 / 829690	AraportID:	AT4G35370	Length:	433	Species:	Arabidopsis thaliana

Alignment Length:	441	Identity:	116/441 - (26%)
Similarity:	214/441 - (48%)	Gaps:	49/441 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VPALCFVPRGVAKDRP-------------DKIVLTQAELARIIGDT--QQELDEESDDDAEEGEN 63
            :.||.::|:..:|..|             |:|...|...|:.:..:  :.::...|..||:|
plant     3 IVALSWIPKEASKAMPVAAESPCMEEKMDDEIQNAQVTHAKSVAKSFGKSKVASSSSTDADE--- 64

  Fly    64 AEEDQNDMDVDDHADANSENRDPQDEFQFQEYDNEANANVTSLANIVDAGEQIPDEDEDSEAEDE 128
            ..:...::|:|::.:.:.|          .|..:....::...:|.:|...:..|.|.|||..|:
plant    65 VVKFLKELDMDNYDEEDDE----------IELFSSGQGHLYYPSNDMDPYLKDTDGDYDSEDHDD 119

  Fly   129 V-IKPSDNLILVGHVQDDAASMEVWVFNQEEEALYTHHDFLLPSFPLCIEWMNHDAGSEKAGNMC 192
            : |:|:|:||:...::.:...:||:|: :|.|.:|..:|.::...|||..|::........||..
plant   120 LTIRPTDSLIICAAIKHEVNYLEVYVY-EESENIYLRNDMIISELPLCTAWLDCPLKGGGKGNFV 183

  Fly   193 AIGCMDPIITVWDLDIQDAIEPTFKLGSKGSRKQNKEQYGHKDAVLDLSWNTNFEHILASGSVDQ 257
            |||.|:..|.:||||:..........|:..|         |...|:||:||..|.:|:||||.|:
plant   184 AIGTMESSIEIWDLDLVCTCATLCTTGTDNS---------HTGPVIDLAWNKEFRNIVASGSEDK 239

  Fly   258 TVILWDMDEGQPHTTITAFGKQIQSLEFHPQEAQSILTGCADGYVRLFDCRDAEGVNSSSIEWKV 322
            .|.:||:..|:...|:....|::.::.::....:.:|:|..|..|.|.|.||.   ::|.::|..
plant   240 KVKVWDVATGKCKVTMEHHEKKVHAVAWNNYTPEVLLSGSRDRTVVLKDGRDP---SNSGLKWST 301

  Fly   323 DGEVEKVLWHPTQTDYFIVGTNDGTLHYADKR----SPGQLLWSVKAHNEEISGVCFNNQKPNLL 383
            :.:|||:.|.|.....|:|...|||:...|.|    ||.   :.:.||:.|:|.:.:|...||||
plant   302 EAKVEKLAWDPHSEHSFVVSLKDGTVKGFDTRASDLSPS---FIIHAHDSEVSSISYNIHAPNLL 363

  Fly   384 TSTSTEGTLKVWNFDGTEAKHVYEHEFNMGRLQCMRQCPEDPYTLAFGGEK 434
            .:.|.:.::|:|:....:...:..::.|.|.:..:....:.|:.||.||.:
plant   364 ATGSADESVKLWDLSNNQPSWIATNKPNAGEVFSVSFSADCPFLLAVGGSE 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nclb	NP_610623.1	WD40	<189..426	CDD:330360	70/240 (29%)
		WD40 repeat	237..274	CDD:293791	17/36 (47%)
		WD40 repeat	282..319	CDD:293791	9/36 (25%)
		WD40 repeat	326..364	CDD:293791	14/41 (34%)
		WD40 repeat	415..454	CDD:293791	5/20 (25%)
AT4G35370	NP_195263.4	WD40	<178..>416	CDD:225201	75/252 (30%)
		WD40	<180..407	CDD:295369	71/241 (29%)
		WD40 repeat	219..256	CDD:293791	17/36 (47%)
		WD40 repeat	263..302	CDD:293791	10/41 (24%)
		WD40 repeat	305..342	CDD:293791	14/39 (36%)
		WD40 repeat	350..388	CDD:293791	9/37 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E1_KOG0270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5129
Inparanoid	1	1.050	190	1.000	Inparanoid score	I1386
OMA	1	1.010	-	-		QHG53981
OrthoDB	1	1.010	-	-		D737539at2759
OrthoFinder	1	1.000	-	-		FOG0003681
OrthoInspector	1	1.000	-	-		otm3377
orthoMCL	1	0.900	-	-		OOG6_102416
Panther	1	1.100	-	-	O	PTHR14091
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2553
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840