DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nclb and AT4G18905

DIOPT Version :9

Sequence 1:	NP_610623.1	Gene:	nclb / 36150	FlyBaseID:	FBgn0263510	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001190765.1	Gene:	AT4G18905 / 827625	AraportID:	AT4G18905	Length:	504	Species:	Arabidopsis thaliana

Alignment Length:	487	Identity:	125/487 - (25%)
Similarity:	234/487 - (48%)	Gaps:	73/487 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VPALCFVPRGVAKDRPD----------KIVLTQAELARIIGDTQQELDEESDDDAEE-------- 60
            :.|:.::|:|..|..||          |.::.....||.:..:.::.:||.::|.||
plant     2 ITAVSWIPKGNLKAVPDVAEPPSKEELKELIESGAFARNVEGSNEDEEEEIEEDGEEISEVDHAK 66

  Fly    61 ------GENAEED--QNDMDVDDHADANSENRDPQDEFQFQEYDNEANANVTSLANIVDAGEQ-- 115
                  |::::..  .:.|:||:.:....|    .|...:.|.|:|.....:.:.::.....:
plant    67 AVAEALGKSSKSKAVSSSMEVDEVSQGLKE----LDMDNYDEEDDEIELFSSGMGDLYYPSNEMD 127

  Fly   116 -----IPDEDEDSEAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQEEEA--LYTHHDFLLPSFP 173
                 :.|||::.:.:|..:||:|::|:....:||.:.:||:::.:...:  :|.||..::|.||
plant   128 PYLKDVDDEDDEEDIDDTTVKPTDSVIICARNEDDVSHLEVYLYEESSGSPNMYVHHHIIIPEFP 192

  Fly   174 LCIEWMNHDAGSEKAGNMCAIGCMD-PIITVWDLDIQDAIEPTFKLGS-----KGSRKQNKEQ-- 230
            ||..|::......:.||..|||..| |.|.:||||::|.:.|..:||.     ...:|::|:|
plant   193 LCTAWLDCPLKGGEKGNFVAIGSKDTPTIEIWDLDVRDEVLPCIQLGGIEEMIVSKKKKSKKQKP 257

  Fly   231 --------------YGHKDAVLDLSWNTNFEHILASGSVDQTVILWDMDEGQPHTTITAFGKQIQ 281
                          ..|.::||.|:||..|.:||||.|.|:.|.:||:..|....|:....|::|
plant   258 VCASNSSISSSSMASSHTESVLGLAWNKEFRNILASASADKKVKVWDVATGTCKITMEHHTKEVQ 322

  Fly   282 SLEFHPQEAQSILTGCADGYVRLFDCRDAEGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDG 346
            ::.::....:.:|:|..|..|.:   :|....:.|..:|.|..:||.:.|.|.....|:|...||
plant   323 AVAWNHYAPEVLLSGSFDQTVVM---KDGRQPSHSGFKWSVMSDVESLAWDPHCEHSFVVSLEDG 384

  Fly   347 TLHYADKR-----SPGQL--LWSVKAHNEE--ISGVCFNNQKPNLLTSTSTEGTLKVWNFDGTEA 402
            |:...|.|     |...|  .::::||.::  :|.:.:|...||||.:.|.:.::|:|:....|.
plant   385 TVKGFDIRAAQSGSDSDLNPTYTIQAHAQDRGVSSISYNISTPNLLATGSMDKSVKLWDLSNNEP 449

  Fly   403 KHVYEHEFNMGRLQCMRQCPEDPYTLAFGGEK 434
            ..:..|:.|.|.:..:....::|:.||.||.|
plant   450 SCIATHQPNAGAVFSISFAVDNPFLLAIGGSK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nclb	NP_610623.1	WD40	<189..426	CDD:330360	75/267 (28%)
		WD40 repeat	237..274	CDD:293791	17/36 (47%)
		WD40 repeat	282..319	CDD:293791	6/36 (17%)
		WD40 repeat	326..364	CDD:293791	13/44 (30%)
		WD40 repeat	415..454	CDD:293791	6/20 (30%)
AT4G18905	NP_001190765.1	WD40	<274..>503	CDD:225201	62/211 (29%)
		WD40	274..>489	CDD:295369	62/211 (29%)
		WD40 repeat	279..316	CDD:293791	16/36 (44%)
		WD40 repeat	321..357	CDD:293791	7/38 (18%)
		WD40 repeat	365..409	CDD:293791	12/43 (28%)
		WD40 repeat	417..454	CDD:293791	10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I2325
eggNOG	1	0.900	-	-		E1_KOG0270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5129
Inparanoid	1	1.050	190	1.000	Inparanoid score	I1386
OMA	1	1.010	-	-		QHG53981
OrthoDB	1	1.010	-	-		D737539at2759
OrthoFinder	1	1.000	-	-		FOG0003681
OrthoInspector	1	1.000	-	-		otm3377
orthoMCL	1	0.900	-	-		OOG6_102416
Panther	1	1.100	-	-	O	PTHR14091
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2553
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840