Protein Alignment nclb and pwp-1

DIOPT Version :10

• Sequence 1: NP_610623.1
• Gene: nclb / 36150
• FlyBaseID: FBgn0263510
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_502541.2
• Gene: pwp-1 / 178277
• WormBaseID: WBGene00010435
• Length: 467
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 147/476 - (30%)
• Similarity: 238/476 - (50%)
• Gaps: 53/476 - (11%)

  Fly    14 VPALCFVPRGVAKDRPDKIVLTQAELARII---------GDTQQELDEESDDDAEEGENAEEDQN 69
            |..|.::.|||||:.||||.|...:|..:|         .:|:.:.|||||::..:|.....|
 Worm     7 VSDLSWIQRGVAKEIPDKIKLDDEKLKELIEGAIPESTDNETELDDDEESDNEKLKGLRGRGD-- 69

  Fly    70 DMDVDDHADANSENRDPQDEFQFQEYDNEANANVTSLANIVD----------------AGEQIPD 118
                       .|.:|.:.||: ::|....|.|:.......|                ..||: |
 Worm    70 -----------VEMKDEESEFE-KKYMKGYNENIKDEPEGQDGMKGIAMYSTNKDDPYVTEQV-D 121

  Fly   119 EDEDSEAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQEEEALYTHHDFLLPSFPLCIEWMNHDA 183
            .||:.|.::.:::..||::.|..:.....::|.:|:|:.:...|.|||::|.:.|||||.:.||.
 Worm   122 SDEEEEKDEIMVRKDDNMVAVAKIDKGDFTLECYVYNEADSDWYCHHDYILDAPPLCIEPVQHDP 186

  Fly   184 GSEKA--GNMCAIGCMDPIITVWDLDIQDAIEPTFKLGSK-------GSRKQNKEQYGHKDAVLD 239
            |:|:.  ||:.|:|.|:..|.:|||||.:...|...||.|       ..:|::....||.|||:.
 Worm   187 GNEETGKGNLLAVGTMNSEIHIWDLDIMNTATPFLTLGKKERKVKGAARKKRDNSAQGHTDAVIS 251

  Fly   240 LSWNTNFEHILASGSVDQTVILWDMDEGQPHTTITAFGKQIQSLEFHPQEAQSILTGCADGYVRL 304
            |:||....|:||||..|:||:|||:||.:|...|...|.:||::::||.|:..:|.|...|.|.:
 Worm   252 LAWNRITTHVLASGGADKTVVLWDLDEAKPAQIIPDQGGEIQTMKWHPNESTFLLLGTMKGQVNV 316

  Fly   305 FDCRDAEGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDGTLHYADKRSPGQLLWSVKAHNEE 369
            .|||::.|  ::|..||.||::|||:|:..........::||.|.:.|.|.||:.||...||:..
 Worm   317 VDCRESSG--NASAAWKFDGQIEKVIWNHFNPFTAFCSSDDGRLRHLDMRKPGECLWEGVAHDGP 379

  Fly   370 ISGVCFNNQKPNLLTSTSTEGTLKVWNFDGTEA--KHVYEHEFNMGRLQCMRQCPEDPYTLAFGG 432
            |.|:..:.....||.:...:..:.||..:.|..  :.|:..:..:|.|.|.:..|:....|:.||
 Worm   380 IGGLTLSALTKGLLVTVGEDEMMNVWKVEDTNGGIEKVHSEKLTIGELHCAQFNPDVAAVLSVGG 444

  Fly   433 EKPPRCAIFNIKNSIAVRRTF 453
            .......|.::.....|.:.|
 Worm   445 TAADLIRIIDLTKYEPVVKAF 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nclb	NP_610623.1	WD40	<189..426	CDD:475233	85/245 (35%)
		WD40 repeat	237..274	CDD:293791	18/36 (50%)
		WD40 repeat	282..319	CDD:293791	12/36 (33%)
		WD40 repeat	326..364	CDD:293791	13/37 (35%)
		WD40 repeat	415..454	CDD:293791	9/39 (23%)
pwp-1	NP_502541.2	WD40	<194..409	CDD:441893	79/216 (37%)
		WD40 repeat	249..285	CDD:293791	18/35 (51%)
		WD40 repeat	293..329	CDD:293791	13/37 (35%)
		WD40 repeat	336..374	CDD:293791	13/37 (35%)
		WD40 repeat	382..426	CDD:293791	7/43 (16%)