DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nclb and Y32H12A.8

DIOPT Version :9

Sequence 1:	NP_610623.1	Gene:	nclb / 36150	FlyBaseID:	FBgn0263510	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_498151.2	Gene:	Y32H12A.8 / 175742	WormBaseID:	WBGene00021316	Length:	3849	Species:	Caenorhabditis elegans

Alignment Length:	444	Identity:	91/444 - (20%)
Similarity:	150/444 - (33%)	Gaps:	144/444 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PRGVAKDRPDKIVLTQAELARIIGDTQQELDEESDDDAEEGEN-AEEDQNDMDVDDHADANSENR 84
            |..|.|....:|:.  ||..|               .:.|||: ..|::..:|:.|..||.|.||
Worm     6 PNNVFKKPSPEILF--AEYGR---------------SSTEGEDPTPENKRVIDLYDPVDAMSLNR 53

  Fly    85 DPQDEFQFQEYDNEANANVTSLANIVDAGEQIPDEDEDSEAEDEVIKPSDNLILVGH--VQDDAA 147
                     |.|....:.:..:..|:.                  |:.|.|.::.|.  |:|
Worm    54 ---------EKDRVVVSGIRGVLQIIK------------------IQNSTNDLIEGPSIVKD--- 88

  Fly   148 SMEVWVFNQ-EEEALYTHHDFLLPSFPLCIEWMNHDAGSEKAGNMCAIGCMDPIITVWDLDIQDA 211
             :::.|:.: :...||:..:         ::|      ::......|....:..|..|::.
Worm    89 -LDMRVYRKGKVNILYSAQN---------VKW------NQLYDQYIATTSSNGSIVCWNIS---- 133

  Fly   212 IEPTFKLGSKGSRKQNKEQY-GHKDAVLDLSWNTNFEHILASGSVDQTVILWDMDEGQPHTTITA 275
                         ::||..: .|:.:...|.|:....:||.|||.|.||..:||.....|
Worm   134 -------------RRNKSVFKSHERSATCLDWHATTPYILVSGSRDCTVKSYDMRVKDNH----- 180

  Fly   276 FGKQIQSLEFHPQEAQSILTGCADGYVRLFDCRDAEGVNSSSIEWKVDGEVEKVLWHPTQTDYFI 340
                  .|.|..:..:||              ||.....:                 |...|||.
Worm   181 ------QLTFSDRNCESI--------------RDVAMCKA-----------------PGFDDYFF 208

  Fly   341 VGTNDGTLHYADKRSPGQLLWSVKAHNEEISGVCFNNQKPNLL-TSTSTEGTLKVWNFDGTEAKH 404
            .|.:.|.|...|.|...:.::...||...:|.:..|.....|: |....:..:|:|.:.|.|...
Worm   209 TGDDGGVLRLWDLRQTRRWVFQKVAHRSFVSTLSLNPHNRTLIATGGGRDKMVKIWEWTGPELNR 273

  Fly   405 --VYEHEFNMGRLQCMRQCPEDPYTLAFGGEKPPRCAIFNIKNSI---AVRRTF 453
              |.|....:||:...   |:.||.||       .||..| :.|:   .|||.:
Worm   274 ISVVETTAPLGRVAWR---PDRPYHLA-------TCASVN-ETSVHVWDVRRPY 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nclb	NP_610623.1	WD40	<189..426	CDD:330360	49/240 (20%)
		WD40 repeat	237..274	CDD:293791	13/36 (36%)
		WD40 repeat	282..319	CDD:293791	6/36 (17%)
		WD40 repeat	326..364	CDD:293791	9/37 (24%)
		WD40 repeat	415..454	CDD:293791	12/42 (29%)
Y32H12A.8	NP_498151.2	WD40 repeat	106..142	CDD:293791	6/67 (9%)
		WD40	136..>360	CDD:392136	57/234 (24%)
		WD40 repeat	148..197	CDD:293791	19/73 (26%)
		WD40 repeat	202..230	CDD:293791	8/27 (30%)
		WD40 repeat	239..267	CDD:293791	6/27 (22%)
		WD40 repeat	274..323	CDD:293791	16/54 (30%)
		WD40 repeat	329..372	CDD:293791
		mRING-H2-C3H3C2_Mio	787..835	CDD:319605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158356
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14091
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940