DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nclb and Pwp1

DIOPT Version :9

Sequence 1:	NP_610623.1	Gene:	nclb / 36150	FlyBaseID:	FBgn0263510	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_598754.2	Gene:	Pwp1 / 103136	MGIID:	1914735	Length:	501	Species:	Mus musculus

Alignment Length:	469	Identity:	171/469 - (36%)
Similarity:	266/469 - (56%)	Gaps:	33/469 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VPALCFVPRGVAKDRPDKIVLTQAELARIIGDTQQELDEESDDDAEEGENAEEDQNDMDVDDHAD 78
            |..:.:|.|||||:.|||:.|::.|:.|:|.:.:.:|.||...:.||..|..||...........
Mouse     7 VTCVAWVRRGVAKETPDKVELSKEEVNRLIAEAKGKLQEEGGSEEEEAGNPSEDGMQSGPTQAPP 71

  Fly    79 ANS-ENRDPQDE----------FQFQEYDNEANANVTSLA------NIVDAGEQIP----DEDED 122
            ..| |:.||||:          :....||.|.|.:..::.      .:..:.:|.|    .:.|.
Mouse    72 RESLEDGDPQDDRTLDDDELAGYDLDNYDEEDNPDAETIGESLLGLTVYGSNDQDPYVTLKDTEQ 136

  Fly   123 SEAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQEEEALYTHHDFLLPSFPLCIEWMNHDAGSE- 186
            .|.||.:|||:||||:.|..:.:..::||.|:|||||:.|.|||.||.::||.:||:|.|...:
Mouse   137 YEHEDFLIKPTDNLIVCGRAEQEQCNLEVHVYNQEEESFYVHHDILLSAYPLSVEWLNFDPSPDA 201

  Fly   187 KAGNMCAIGCMDPIITVWDLDIQDAIEPTFKLGSKGSRKQNKE------QYGHKDAVLDLSWNTN 245
            ..||..|:|.|.|:|.||||||.|::||.|.||||.|:|:.|:      ..||.|||||||||..
Mouse   202 STGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKT 266

  Fly   246 FEHILASGSVDQTVILWDMDEGQPHTTITAFGKQIQSLEFHPQEAQSILTGCADGYVRLFDCRDA 310
            ..::|||.|.|.||:|||:..|:....:||...::|:|:|||.|||::::|..|..|.|:||||.
Mouse   267 VRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRDP 331

  Fly   311 EGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDGTLHYADKRSPGQLLWSVKAHNEEISGVCF 375
               :.:..:|:..|::|:|.|:.....:|:..|:||.::..|.|| .:.::::.|||:||||:..
Mouse   332 ---SQNHRQWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS-DKPIFTLNAHNDEISGLDL 392

  Fly   376 NNQKPNLLTSTSTEGTLKVWNFDGTEAKHVYEHEFNMGRLQCMRQCPEDPYTLAFGGEKPPRCAI 440
            ::|....|.:.|.:..:|:|:..|.....::..:..||.|.|...||:.|:..||||:| ....:
Mouse   393 SSQIKGCLVTASADKFVKIWDILGDRPSLIHSRDMKMGVLFCSSCCPDLPFVYAFGGQK-EGLRV 456

  Fly   441 FNIKNSIAVRRTFG 454
            ::|....:|...||
Mouse   457 WDISTVSSVNEAFG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nclb	NP_610623.1	WD40	<189..426	CDD:330360	95/242 (39%)
		WD40 repeat	237..274	CDD:293791	18/36 (50%)
		WD40 repeat	282..319	CDD:293791	15/36 (42%)
		WD40 repeat	326..364	CDD:293791	10/37 (27%)
		WD40 repeat	415..454	CDD:293791	12/38 (32%)
Pwp1	NP_598754.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..107		18/68 (26%)
		WD 1	185..229		20/43 (47%)
		WD40	<252..493	CDD:225201	81/224 (36%)
		WD40	<252..413	CDD:295369	63/164 (38%)
		WD 2	253..293		22/39 (56%)
		WD40 repeat	258..295	CDD:293791	18/36 (50%)
		WD 3	296..336		17/42 (40%)
		WD40 repeat	302..341	CDD:293791	17/41 (41%)
		WD40 repeat	344..381	CDD:293791	10/37 (27%)
		WD 4	382..422		13/39 (33%)
		WD40 repeat	389..422	CDD:293791	7/32 (22%)
		WD 5	427..467		14/40 (35%)
		WD40 repeat	432..457	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834818
Domainoid	1	1.000	163	1.000	Domainoid score	I3965
eggNOG	1	0.900	-	-		E1_KOG0270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5129
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2546
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53981
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003681
OrthoInspector	1	1.000	-	-		oto92248
orthoMCL	1	0.900	-	-		OOG6_102416
Panther	1	1.100	-	-	LDO	PTHR14091
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1728
SonicParanoid	1	1.000	-	-		X2553
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790