Protein Alignment nclb and Pwp1

DIOPT Version :10

• Sequence 1: NP_610623.1
• Gene: nclb / 36150
• FlyBaseID: FBgn0263510
• Length: 459
• Species: Drosophila melanogaster
• Sequence 2: NP_598754.2
• Gene: Pwp1 / 103136
• MGIID: 1914735
• Length: 501
• Species: Mus musculus
• Alignment Length: 469
• Identity: 171/469 - (36%)
• Similarity: 266/469 - (56%)
• Gaps: 33/469 - (7%)

  Fly    14 VPALCFVPRGVAKDRPDKIVLTQAELARIIGDTQQELDEESDDDAEEGENAEEDQNDMDVDDHAD 78
            |..:.:|.|||||:.|||:.|::.|:.|:|.:.:.:|.||...:.||..|..||...........
Mouse     7 VTCVAWVRRGVAKETPDKVELSKEEVNRLIAEAKGKLQEEGGSEEEEAGNPSEDGMQSGPTQAPP 71

  Fly    79 ANS-ENRDPQDE----------FQFQEYDNEANANVTSLA------NIVDAGEQIP----DEDED 122
            ..| |:.||||:          :....||.|.|.:..::.      .:..:.:|.|    .:.|.
Mouse    72 RESLEDGDPQDDRTLDDDELAGYDLDNYDEEDNPDAETIGESLLGLTVYGSNDQDPYVTLKDTEQ 136

  Fly   123 SEAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQEEEALYTHHDFLLPSFPLCIEWMNHDAGSE- 186
            .|.||.:|||:||||:.|..:.:..::||.|:|||||:.|.|||.||.::||.:||:|.|...:
Mouse   137 YEHEDFLIKPTDNLIVCGRAEQEQCNLEVHVYNQEEESFYVHHDILLSAYPLSVEWLNFDPSPDA 201

  Fly   187 KAGNMCAIGCMDPIITVWDLDIQDAIEPTFKLGSKGSRKQNKE------QYGHKDAVLDLSWNTN 245
            ..||..|:|.|.|:|.||||||.|::||.|.||||.|:|:.|:      ..||.|||||||||..
Mouse   202 STGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKT 266

  Fly   246 FEHILASGSVDQTVILWDMDEGQPHTTITAFGKQIQSLEFHPQEAQSILTGCADGYVRLFDCRDA 310
            ..::|||.|.|.||:|||:..|:....:||...::|:|:|||.|||::::|..|..|.|:||||.
Mouse   267 VRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRDP 331

  Fly   311 EGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDGTLHYADKRSPGQLLWSVKAHNEEISGVCF 375
               :.:..:|:..|::|:|.|:.....:|:..|:||.::..|.|| .:.::::.|||:||||:..
Mouse   332 ---SQNHRQWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS-DKPIFTLNAHNDEISGLDL 392

  Fly   376 NNQKPNLLTSTSTEGTLKVWNFDGTEAKHVYEHEFNMGRLQCMRQCPEDPYTLAFGGEKPPRCAI 440
            ::|....|.:.|.:..:|:|:..|.....::..:..||.|.|...||:.|:..||||:| ....:
Mouse   393 SSQIKGCLVTASADKFVKIWDILGDRPSLIHSRDMKMGVLFCSSCCPDLPFVYAFGGQK-EGLRV 456

  Fly   441 FNIKNSIAVRRTFG 454
            ::|....:|...||
Mouse   457 WDISTVSSVNEAFG 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nclb	NP_610623.1	WD40	<189..426	CDD:475233	95/242 (39%)
		WD40 repeat	237..274	CDD:293791	18/36 (50%)
		WD40 repeat	282..319	CDD:293791	15/36 (42%)
		WD40 repeat	326..364	CDD:293791	10/37 (27%)
		WD40 repeat	415..454	CDD:293791	12/38 (32%)
Pwp1	NP_598754.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..107		18/68 (26%)
		WD 1	185..229		20/43 (47%)
		WD40	<198..286	CDD:441893	45/87 (52%)
		WD40	<252..413	CDD:475233	63/164 (38%)
		WD 2	253..293		22/39 (56%)
		WD40 repeat	258..295	CDD:293791	18/36 (50%)
		WD 3	296..336		17/42 (40%)
		WD40 repeat	302..341	CDD:293791	17/41 (41%)
		WD40 repeat	344..381	CDD:293791	10/37 (27%)
		WD 4	382..422		13/39 (33%)
		WD40 repeat	389..422	CDD:293791	7/32 (22%)
		WD 5	427..467		14/40 (35%)
		WD40 repeat	432..457	CDD:293791	10/25 (40%)