DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nclb and pwp1

DIOPT Version :9

Sequence 1:	NP_610623.1	Gene:	nclb / 36150	FlyBaseID:	FBgn0263510	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_004912880.1	Gene:	pwp1 / 100379913	XenbaseID:	XB-GENE-978886	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	174/497 - (35%)
Similarity:	275/497 - (55%)	Gaps:	67/497 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VPALCFVPRGVAKDRPDKIVLTQAELARIIGDTQQELD--------------------EESDDDA 58
            :..|.:|.|||||:.|||:.|::|||.|:|.:.:::|:                    |..:|:|
Frog     5 ITCLSWVSRGVAKESPDKVQLSEAELTRLISEAKEQLEIPLRGFLFCICSLPSNRGELEGDEDEA 69

  Fly    59 EEGENAEEDQNDMDVDDHADANSENRDPQD--------------EFQFQEYDNEANANVTSL--- 106
            |:.|.     ::|:.::.|:||...:|.::              |:....||.|...:|.:|
Frog    70 EQNEG-----DNMESNEEAEANEAPQDGEEQEESISKLNDDELAEYDLDNYDEEGRTDVINLGDS 129

  Fly   107 --------ANIVDAGEQIPDEDEDSEAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQEEEALYT 163
                    :|..||...:.| .|..|.||.||||:|||::.|..:.|..::|:.|:||||::.|.
Frog   130 LAGLSVYSSNEEDAYVTLKD-TEQYEKEDYVIKPTDNLLVCGRAEKDHCNLEIHVYNQEEDSFYV 193

  Fly   164 HHDFLLPSFPLCIEWMNHDAGSEKA-GNMCAIGCMDPIITVWDLDIQDAIEPTFKLGSKGSRKQN 227
            |||.|||::|||.||:|.|...|:: ||..|:|.|.|:|.|||||:.|.:||.|.||.|.::|:.
Frog   194 HHDILLPAYPLCTEWLNFDPSPEESTGNYVAVGNMTPVIDVWDLDLVDCLEPVFSLGCKQTKKKK 258

  Fly   228 KE----------QYGHKDAVLDLSWNTNFEHILASGSVDQTVILWDMDEGQPHTTITAFGKQIQS 282
            |:          |.||.|||||||||....::|||.|.|.||:||||..|:|..::|....::|:
Frog   259 KKGKKGASSEGTQEGHSDAVLDLSWNKQIRNVLASASADNTVLLWDMSIGKPAASLTMHTDKVQT 323

  Fly   283 LEFHPQEAQSILTGCADGYVRLFDCRDAEGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDGT 347
            |.|||.|.|::::|..|....|:|||..:   .:...|:..|:||:|:|:......|:..|:||.
Frog   324 LHFHPFEPQTLISGSFDKSAILYDCRSPQ---ENHRTWRFSGQVERVVWNHFSPRNFLASTDDGF 385

  Fly   348 LHYADKRSPGQLLWSVKAHNEEISGVCFNNQKPNLLTSTSTEGTLKVWNFDGTEAKHVYEHEFNM 412
            ::..|.|| .:.|:::|||:.|:||:..::|....|.::|.:..:|:|:....:...|:.....|
Frog   386 VYCLDARS-DKPLFTIKAHDGEVSGLALSSQIKGCLVTSSEDKYVKIWDIMLDKPSLVHSRNMKM 449

  Fly   413 GRLQCMRQCPEDPYTLAFGGEKPPRCAIFNIKNSIAVRRTFG 454
            |.|.|...||:.|:..||||:| ....:::|....||:..||
Frog   450 GVLFCAACCPDLPFLYAFGGQK-DGLRVWDISTIAAVKEAFG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nclb	NP_610623.1	WD40	<189..426	CDD:330360	92/246 (37%)
		WD40 repeat	237..274	CDD:293791	20/36 (56%)
		WD40 repeat	282..319	CDD:293791	12/36 (33%)
		WD40 repeat	326..364	CDD:293791	12/37 (32%)
		WD40 repeat	415..454	CDD:293791	13/38 (34%)
pwp1	XP_004912880.1	WD40	270..515	CDD:392136	82/226 (36%)
		WD40 repeat	278..315	CDD:293791	20/36 (56%)
		WD40 repeat	322..359	CDD:293791	13/39 (33%)
		WD40 repeat	364..401	CDD:293791	12/37 (32%)
		WD40 repeat	409..448	CDD:293791	7/38 (18%)
		WD40 repeat	453..477	CDD:293791	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3836
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5129
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2526
OMA	1	1.010	-	-		QHG53981
OrthoDB	1	1.010	-	-		D304388at33208
OrthoFinder	1	1.000	-	-		FOG0003681
OrthoInspector	1	1.000	-	-		oto102549
Panther	1	1.100	-	-	LDO	PTHR14091
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2553
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080