Protein Alignment IMPDH2 and ras

DIOPT Version :10

• Sequence 1: NP_001397688.1
• Gene: IMPDH2 / 3615
• HGNCID: 6053
• Length: 538
• Species: Homo sapiens
• Sequence 2: NP_001356940.1
• Gene: ras / 43873
• FlyBaseID: FBgn0003204
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 346/527 - (65%)
• Similarity: 420/527 - (79%)
• Gaps: 31/527 - (5%)

Human    16 DGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAI 80
            |||:.::||..|:||||||||||||||||||::|||:|.|||.:||:.||||||||||||:.|||
  Fly    38 DGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTESEMAI 102

Human    81 AMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPIT 145
            ||||.||||.||||||||:||.||.|||||:.||:.||.|:||.:.|.||.||:.::||.|.|:|
  Fly   103 AMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKNGFTGYPVT 167

Human   146 DTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLP 210
            :.|::|.:|:|:::|||||| :|.:.:..|.:|||  .:||.||.||.|..||.||::|||||||
  Fly   168 ENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILEKSKKGKLP 229

Human   211 IVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDS 275
            |||:..||||:||||||||.|.||.||||:.||||.||||||..:||.||.||...||||::|||
  Fly   230 IVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANGVDVIILDS 294

Human   276 SQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVAPKI 340
            |||||::|:.||||||:.||.||||||||||.||||||||||||.||||||||||||||||
  Fly   295 SQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICITQEV---- 355

Human   341 PPDIKSHSPKCPSTVTGCYMLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGA 405
                                :|||.|||||||:||.|||:||||||||||||::|||.||:||||
  Fly   356 --------------------MACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGA 400

Human   406 STVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM---DKHLSSQNRYF-SEADKIKVAQG 466
            |.||||||||.|:|||||||||||:|||||||||||:||   |...::.:||: :|.||:|||||
  Fly   401 SAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQG 465

Human   467 VSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLH 531
            |||::.||||:.:::|||..|:|||||||||.|:.::|.|:|:|:|:|.|||.|||:||.||.|.
  Fly   466 VSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLF 530

Human   532 SYEKRLF 538
            |||||||
  Fly   531 SYEKRLF 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IMPDH2	NP_001397688.1	PLN02274	15..538	CDD:215154	344/525 (66%)
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	340/521 (65%)