Protein Alignment LTV1 and LTV1

DIOPT Version :10

• Sequence 1: NP_610620.1
• Gene: LTV1 / 36146
• FlyBaseID: FBgn0027525
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_116249.2
• Gene: LTV1 / 84946
• HGNCID: 21173
• Length: 475
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 214/532 - (40%)
• Similarity: 298/532 - (56%)
• Gaps: 106/532 - (19%)

  Fly     5 KKPYIDRKKAVTFHLVHRSQHDPLVTDENAPQRVLLEAAARQQKPKDPEPPTDPAQRQEELKKFG 69
            |||:|::||||:||||||||.|||..||:|||||||           |....|..:|:.|.:|:|
Human     6 KKPFIEKKKAVSFHLVHRSQRDPLAADESAPQRVLL-----------PTQKIDNEERRAEQRKYG 59

  Fly    70 IHFDDDYDYMQHLKKRE--NDVVWEFMENPNQARKQKVQDSEKPGPAPKLMLPSSVFASEFEESE 132
            :.|||||||:||||:..  ::::.....:.:..|::|.:....|....|  ||||||||||||..
Human    60 VFFDDDYDYLQHLKEPSGPSELIPSSTFSAHNRREEKEETLVIPSTGIK--LPSSVFASEFEEDV 122

  Fly   133 GMLNKAAPQT-LRLDWDPDVVAALDSDCENEE----LEDDFVIQA-MAEGD-----------SDD 180
            |:||||||.: .|||:|||:|||||.|.:.::    |||||::|| .|.|:           .||
Human   123 GLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPDNLLEDDFILQANKATGEEEGMDIQKSENEDD 187

  Fly   181 EEWDDEDGEE-QSDMDFDSDDLNEDENEDELMDRLAPLMRERRFDDEEVKSRFTEYSMSSSVIRR 244
            .||:|.|.|: .|:.|:||..|..||:...:..:....:.:..|..||.|||||||||:|||:||
Human   188 SEWEDVDDEKGDSNDDYDSAGLLSDEDCMSVPGKTHRAIADHLFWSEETKSRFTEYSMTSSVMRR 252

  Fly   245 NEQLSLLDDRFEKFYATYDDPELGDLALEDIEGNWHQKHPVVMQCFQEFKKKDKGIEYNKEWDRE 309
            ||||:|.|:||||||..|||.|:|.|...::||:.......:.:...::.|
Human   253 NEQLTLHDERFEKFYEQYDDDEIGALDNAELEGSIQVDSNRLQEVLNDYYK-------------- 303

  Fly   310 RIEKYRNVV----------------EGEEDPTEELVEYEVDDPKQKKWDCESILSTYSNIYNHPK 358
              ||..|.|                |.:|...||::...:::.|: |||||||.|||||:||||:
Human   304 --EKAENCVKLNTLEPLEDQDLPMNELDESEEEEMITVVLEEAKE-KWDCESICSTYSNLYNHPQ 365

  Fly   359 VID-EPRRSRRSSASTNPAPIQIDPKTGLPTNVL--RGGVDGQLTAK-----ALANLADESPAAT 415
            :|. :|:          |..|:|..|||:|.|||  :|     ||||     .:.|.:|....:|
Human   366 LIKYQPK----------PKQIRISSKTGIPLNVLPKKG-----LTAKQTERIQMINGSDLPKVST 415

  Fly   416 GPKSLCAKSVLSTLSVLSIRPKDETHEEKKERKRLLKDYRNERRIEKKANTEAFKEEKKRQTHVK 480
            .|:|                 |:|:.|:|:.||:.:|:.|.|||:|||||..|||.||:||....
Human   416 QPRS-----------------KNESKEDKRARKQAIKEERKERRVEKKANKLAFKLEKRRQEKEL 463

  Fly   481 INQRTNQQGASI 492
            :|.:.|.:|..:
Human   464 LNLKKNVEGLKL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LTV1	NP_610620.1	LTV	10..356	CDD:461211	159/381 (42%)
LTV1	NP_116249.2	LTV	15..363	CDD:461211	161/384 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..54		15/30 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..99		10/26 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..213		19/56 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..447		9/41 (22%)