DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LTV1 and LTV1

DIOPT Version :9

Sequence 1:	NP_001286300.1	Gene:	LTV1 / 36146	FlyBaseID:	FBgn0027525	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_116249.2	Gene:	LTV1 / 84946	HGNCID:	21173	Length:	475	Species:	Homo sapiens

Alignment Length:	532	Identity:	214/532 - (40%)
Similarity:	298/532 - (56%)	Gaps:	106/532 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKPYIDRKKAVTFHLVHRSQHDPLVTDENAPQRVLLEAAARQQKPKDPEPPTDPAQRQEELKKFG 69
            |||:|::||||:||||||||.|||..||:|||||||           |....|..:|:.|.:|:|
Human     6 KKPFIEKKKAVSFHLVHRSQRDPLAADESAPQRVLL-----------PTQKIDNEERRAEQRKYG 59

  Fly    70 IHFDDDYDYMQHLKKRE--NDVVWEFMENPNQARKQKVQDSEKPGPAPKLMLPSSVFASEFEESE 132
            :.|||||||:||||:..  ::::.....:.:..|::|.:....|....|  ||||||||||||..
Human    60 VFFDDDYDYLQHLKEPSGPSELIPSSTFSAHNRREEKEETLVIPSTGIK--LPSSVFASEFEEDV 122

  Fly   133 GMLNKAAPQT-LRLDWDPDVVAALDSDCENEE----LEDDFVIQA-MAEGD-----------SDD 180
            |:||||||.: .|||:|||:|||||.|.:.::    |||||::|| .|.|:           .||
Human   123 GLLNKAAPVSGPRLDFDPDIVAALDDDFDFDDPDNLLEDDFILQANKATGEEEGMDIQKSENEDD 187

  Fly   181 EEWDDEDGEE-QSDMDFDSDDLNEDENEDELMDRLAPLMRERRFDDEEVKSRFTEYSMSSSVIRR 244
            .||:|.|.|: .|:.|:||..|..||:...:..:....:.:..|..||.|||||||||:|||:||
Human   188 SEWEDVDDEKGDSNDDYDSAGLLSDEDCMSVPGKTHRAIADHLFWSEETKSRFTEYSMTSSVMRR 252

  Fly   245 NEQLSLLDDRFEKFYATYDDPELGDLALEDIEGNWHQKHPVVMQCFQEFKKKDKGIEYNKEWDRE 309
            ||||:|.|:||||||..|||.|:|.|...::||:.......:.:...::.|
Human   253 NEQLTLHDERFEKFYEQYDDDEIGALDNAELEGSIQVDSNRLQEVLNDYYK-------------- 303

  Fly   310 RIEKYRNVV----------------EGEEDPTEELVEYEVDDPKQKKWDCESILSTYSNIYNHPK 358
              ||..|.|                |.:|...||::...:::.|: |||||||.|||||:||||:
Human   304 --EKAENCVKLNTLEPLEDQDLPMNELDESEEEEMITVVLEEAKE-KWDCESICSTYSNLYNHPQ 365

  Fly   359 VID-EPRRSRRSSASTNPAPIQIDPKTGLPTNVL--RGGVDGQLTAK-----ALANLADESPAAT 415
            :|. :|:          |..|:|..|||:|.|||  :|     ||||     .:.|.:|....:|
Human   366 LIKYQPK----------PKQIRISSKTGIPLNVLPKKG-----LTAKQTERIQMINGSDLPKVST 415

  Fly   416 GPKSLCAKSVLSTLSVLSIRPKDETHEEKKERKRLLKDYRNERRIEKKANTEAFKEEKKRQTHVK 480
            .|:|                 |:|:.|:|:.||:.:|:.|.|||:|||||..|||.||:||....
Human   416 QPRS-----------------KNESKEDKRARKQAIKEERKERRVEKKANKLAFKLEKRRQEKEL 463

  Fly   481 INQRTNQQGASI 492
            :|.:.|.:|..:
Human   464 LNLKKNVEGLKL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LTV1	NP_001286300.1	LTV	10..462	CDD:282087	195/495 (39%)
LTV1	NP_116249.2	LTV	15..445	CDD:398035	185/473 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..54		15/30 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..99		10/26 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..213		19/56 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..447		9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149895
Domainoid	1	1.000	295	1.000	Domainoid score	I1486
eggNOG	1	0.900	-	-		E1_KOG2637
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6338
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2478
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51932
OrthoDB	1	1.010	-	-		D403171at33208
OrthoFinder	1	1.000	-	-		FOG0005029
OrthoInspector	1	1.000	-	-		oto90017
orthoMCL	1	0.900	-	-		OOG6_104128
Panther	1	1.100	-	-	LDO	PTHR21531
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R673
SonicParanoid	1	1.000	-	-		X3551
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800