Protein Alignment alka and GLRA3

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 136/424 - (32%)
• Similarity: 212/424 - (50%)
• Gaps: 54/424 - (12%)

  Fly    44 YVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRL---EIPDDIFEEGD 105
            |...|| |:.||.||.|..:||:....||....||:||::|:.|:|.:.||   |.|||..:
Human    57 YDARIR-PNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLD--- 117

  Fly   106 DYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLY 170
                |.|.:.::.|:||.:|.|.|.|....:|.....:.::||..|.|:.|:...::|.|:.:.:
Human   118 ----LDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNF 178

  Fly   171 PMDIQVCPIYIESFSSNNQKVKLRWSDSG-VTLNPELKLLQYNLGQPLELEESDGYMPEKVGNFS 234
            |||:|.|.:.:|||......:...|.|.. |.:...|.|.|:.|.:..:|.....:.  ..|.|:
Human   179 PMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHY--NTGKFT 241

  Fly   235 RLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTG--AD 297
            .:.|.|..|||:|::|||.:.||.|:|:|||.|||:.:||.|.||.|.:|.:||:.|..:|  |.
Human   242 CIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRAS 306

  Fly   298 IPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVA 362
            :|.|:||||:|:|||.|:|.||:||.|:..|..:..|::       ::|..|.....|.:...:.
Human   307 LPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHK-------ELLRFRRKRKNKTEAFALE 364

  Fly   363 SW-----EGGAVRSRKATQTPTTPGQTSLQGNG----GPPKPAR---------RQSLLSVAWTDT 409
            .:     ....||..:.:.|....|......:|    ||..|.:         |:..:..|
Human   365 KFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRA---- 425

  Fly   410 DTGVEKIMWREIDKVSRAVFPILFFVFVLLYWPI 443
                     ::||.:|||.||:.|.:|.:.||.|
Human   426 ---------KKIDTISRACFPLAFLIFNIFYWVI 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	133/420 (32%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	136/424 (32%)