DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12344 and gabrz

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001108214.2	Gene:	gabrz / 561738	ZFINID:	ZDB-GENE-080303-26	Length:	447	Species:	Danio rerio

Alignment Length:	471	Identity:	132/471 - (28%)
Similarity:	222/471 - (47%)	Gaps:	64/471 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AFISFGLGFILMWLSEATEAHMNYTAKPRVVLPP-------NYVKEIRPPSKKGSPVIVDFSIFV 66
            :|:.|.|  :|:::|...:..:   |....:|||       .|.|.:||....| ||.|..|:.:
Zfish     5 SFVGFLL--LLLFISRIMDGSV---ANTEEILPPTIQKLMKGYNKYLRPFFGNG-PVTVGMSLDI 63

  Fly    67 VDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIA 131
            ..|::|:..:||:...:|:.|||.:.||..      :|:..::|...:.|..|.||.:.::||.:
Zfish    64 ASIDTISEINMDYTATIFLRQRWTDERLCF------DGNKSLSLDGRLVELLWVPDTFIVDSKKS 122

  Fly   132 EIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWS 196
            .:..:|.:...:.::.|.||.||.|:...:||.|:...||||.|.|.:.:||:..|.:.|...|:
Zfish   123 FLHDITVENRLIRIFPNGTVLYALRITTTVACSMDLTKYPMDRQTCMLQLESWGYNVKDVVFYWT 187

  Fly   197 --DSGVTLNPELKLLQYNLGQPLELEESDGYMPE-----KVGNFSRLTVYFRFERQIGHHLIQTF 254
              :..|:....|:|.||.|        .|.|..|     :.||:.:|..:|:.:|.|.:.:::|:
Zfish   188 RGNQSVSGLDHLQLAQYTL--------EDHYTSESEAVYETGNYPKLIFHFKLKRSILYFILETY 244

  Fly   255 APSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPV-AYVKALDLWMAGCML 316
            .|||.:|:|||.|||:...::|.|:.:.||.:||:.|:..||  .:|.. .::||:|:::..|..
Zfish   245 VPSSALVVLSWVSFWISQSSVPARICIGVTTVLTMTTLMMGARTSLPNANCFIKAIDVYLGICFS 309

  Fly   317 SVFAALAEFVVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTP 381
            .:|.||.|:.|.....:......|..  :....:...|......|.|:...|:|:||..:
Zfish   310 FIFGALIEYAVAHFCTLHQPNAANAY--MYGQEMQEREDEMNGIVTSFGSHALRARKREE----- 367

  Fly   382 GQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWRE-----------------IDKVSRAVF 429
             ..|..|:...|.|:  :|...|:.:...|...|.|.|.                 ||..||..|
Zfish   368 -MLSRMGSVNNPTPS--ESKEDVSSSQPQTRCTKCMSRARRIIRCLYCCKVENPHYIDNYSRLTF 429

  Fly   430 PILFFVFVLLYWPILL 445
            |:.|.:..||||...|
Zfish   430 PLSFVIINLLYWTYYL 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	129/465 (28%)
gabrz	NP_001108214.2	LIC	26..444	CDD:273305	125/442 (28%)
gabrz	NP_001108214.2	LGIC_ECD_GABAAR_pi	54..235	CDD:349805	56/194 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810