DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12344 and GABRQ

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_061028.3	Gene:	GABRQ / 55879	HGNCID:	14454	Length:	632	Species:	Homo sapiens

Alignment Length:	405	Identity:	120/405 - (29%)
Similarity:	195/405 - (48%)	Gaps:	48/405 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILMWLSEAT------EAHMNY-TAKPRVVLP---------------------PNYVKEIRPPSKK 54
            |..||:|..      :.|..: :|.|.|||.                     ..|...:| |:..
Human    16 IRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQKILDRVLSRYDVRLR-PNFG 79

  Fly    55 GSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFW 119
            |:||.|..||:|..|..|:..:||:.:.||.||.|.:|||     .:.|....:||...:.|..|
Human    80 GAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL-----AYYETTLNLTLDYRMHEKLW 139

  Fly   120 QPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESF 184
            .||.||||||.|.:..:|.:.....|:.:.||||..|:....||.::...:|||.|.|.:.:||:
Human   140 VPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESY 204

  Fly   185 SSNNQKVKLRWSDSG--VTLNPELKLLQYN-LGQPLELEESDGYMPEKVGNFSRLTVYFRFERQI 246
            ....:.:.|.|.|:|  :.:..||.:.|:. ||:.:..:|...|    .|::.||.:.|:.:|::
Human   205 GYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFY----TGSYIRLILKFQVQREV 265

  Fly   247 GHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDL 309
            ..:|:|.:.|:.|..:.||.|||:..|:...|||:.:|.||.|.|:.:..  .:|.::.:||:|:
Human   266 NSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDI 330

  Fly   310 WMAGCMLSVFAALAEFVVVKVLDVQYQYQVNRIPK--VLPMRISNMEKGQCATVASWEGGAVRSR 372
            ::..|:..||.:|.|:|.:..|  .|.....|.|:  ..|.|:....:.|...|.:.:.|.:...
Human   331 YILVCLFFVFLSLLEYVYINYL--FYSRGPRRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVE 393

  Fly   373 KATQT-PTTPGQTSL 386
            ....: |.||.|..|
Human   394 DGVSSLPITPAQAPL 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	120/405 (30%)
GABRQ	NP_061028.3	Neur_chan_LBD	60..>353	CDD:332142	97/304 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..458
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810