DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12344 and gabrg1

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	XP_009305483.1	Gene:	gabrg1 / 556202	ZFINID:	ZDB-GENE-141215-66	Length:	454	Species:	Danio rerio

Alignment Length:	477	Identity:	119/477 - (24%)
Similarity:	205/477 - (42%)	Gaps:	93/477 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LMWL-------------SEATE-------AHMNYTAKPRVV----------LPPNYVKEIRPPSK 53
            |:||             |:|.|       .:..:...|:|.          |...|..::||...
Zfish    11 LVWLLPGLLGVCMAFGPSKAEEEDYEDVPINKTWVLSPKVYESDVTLILNKLLQGYDNKLRPDIG 75

  Fly    54 KGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENF 118
            . .|.:::.:::|..|..::..:|::.:|:|..|.|.:|||:     |......:.|...:....
Zfish    76 V-RPTVIETAVYVNSIGPVDPINMEYTIDIFFAQTWYDSRLK-----FNSSMKLLMLNSNMVGKI 134

  Fly   119 WQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIES 183
            |.||.:|.||:.::...:|.....:.|:.|..|.|..|:.....|.::...:|||...||:...|
Zfish   135 WIPDTFFRNSRKSDAHWITTPNRLLRLWSNGRVMYTLRLTINAECYLKLHNFPMDEHSCPLEFSS 199

  Fly   184 FSSNNQKVKLRWSDSGVTLNPE--LKLLQYNLGQPLELEESDGYMPEKVGNFSRLTVYFRFERQI 246
            :.....:::.||....|.:..:  .:|.|:..   :.|..|......:.|.:..:|::|...|::
Zfish   200 YGYPKNEIQYRWQRRSVEVADQRYWRLYQFAF---VGLRNSSDVANTQSGEYVVMTIFFDLSRRM 261

  Fly   247 GHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFT--GADIPPVAYVKALDL 309
            |:..|||:.|.|::|:|||.|||:..||:|.|.:|.:|.:||:.|:.|  ...:|.|:||.|:||
Zfish   262 GYFTIQTYIPCSMIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTISRKSLPKVSYVTAMDL 326

  Fly   310 WMAGCMLSVFAALAEFVVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKA 374
            :::.|.:..||||.|:..:      :.:..||..|              .|.:|      .::|.
Zfish   327 FVSVCFIFTFAALMEYGTL------HYFTSNRQNK--------------KTKSS------HAQKP 365

  Fly   375 TQTPTTPGQTSLQGNGGPP-----------KPARRQSLLSVAWTDTDTGVEKIMWRE-------- 420
            :.....||.:.||.|...|           ...:..:.....:.|..:|.    |||
Zfish   366 SMVNIRPGTSLLQMNNIAPYHEDDDYAYECLDGKDCTSFFCCFDDCRSGA----WRENRMHVHVS 426

  Fly   421 -IDKVSRAVFPILFFVFVLLYW 441
             ||..||..||..|.:|.|:||
Zfish   427 KIDSYSRIFFPTAFGLFNLVYW 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	117/475 (25%)
gabrg1	XP_009305483.1	Neur_chan_LBD	56..261	CDD:280998	47/213 (22%)
		LIC	58..451	CDD:273305	111/430 (26%)
		Neur_chan_memb	268..448	CDD:280999	59/209 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920