Protein Alignment alka and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 371
• Identity: 81/371 - (21%)
• Similarity: 161/371 - (43%)
• Gaps: 57/371 - (15%)

  Fly    17 FILMWLSEATEAHMNYTAKPRVV-----LPPNYVKEIRPPSKKGSPVIVDFSIFVVDINSINVED 76
            |:|:.|:.:| |.:::.|.|...     |..||.:.|||.......:.|...:.:..:..:|:::
  Fly    10 FLLVPLANST-APISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKN 73

  Fly    77 MDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFT 141
            .....::::.|||.:.:|..  |..|.|......:|.  |:.|.||....|:.....
  Fly    74 QVMTTNLWVKQRWFDYKLRW--DPEEYGGVEQLYVPS--EHIWVPDIVLYNNWDGNY-------- 126

  Fly   142 SVTLYKNKTVRYAARMH----AII--ACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDS-- 198
            .|||....|::|...:.    ||.  :|:|..:.:|.|.|:|.:...|::.|..:|.|:..|.
  Fly   127 EVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIP 191

  Fly   199 -------GVTLNPELKLLQYNLGQPLEL--EESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTF 254
                   |:.|......:::::   ||:  .:::.|.|:.:..||.:|......|:...:.:...
  Fly   192 GSNLVQVGIDLTEFYLSVEWDI---LEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLI 253

  Fly   255 APSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMF--TGADIPPVAY-VKALDLWMAGCML 316
            .|...:..|:...|:|..|: ..:|||.::.:::|...|  ....|||.:. |..|..::...|:
  Fly   254 VPCVALTFLTVLVFYLPSDS-GEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMI 317

  Fly   317 SVFAALAEFVVVKVLDVQYQYQ-------------VNRIPKVLPMR 349
            .|  :|:.:..|.||::.::..             ::.:||::.||
  Fly   318 LV--SLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMR 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	81/371 (22%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	81/371 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	49/232 (21%)
		Cys-loop	154..168	CDD:349832	5/13 (38%)