Protein Alignment alka and nAChRalpha4

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 314
• Identity: 65/314 - (20%)
• Similarity: 129/314 - (41%)
• Gaps: 38/314 - (12%)

  Fly    43 NYVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDY 107
            ||.|.:||.......:.|...:.:..:..:|:::.....::::.|.|.:.:|.      .|..:|
  Fly    22 NYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLR------WEPKEY 80

  Fly   108 --VTLLPEVFENFWQPDPYFLNSKIAEI-ATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQL 169
              |.:|....::.|:||....|:..... .||.   |..|:|....|.:........:|:::.:.
  Fly    81 GGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLA---TKATIYSEGLVEWKPPAIYKSSCEIDVEY 142

  Fly   170 YPMDIQVCPIYIESFSSNNQKVKLRWSDS---------GVTLNPELKLLQYNLGQPLELEESDGY 225
            :|.|.|.|.:...|::.:..||.||..|.         ||.|:      ::.:....::.|....
  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLS------EFYMSVEWDILEVPAV 201

  Fly   226 MPEKVGN-----FSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTC 285
            ..||...     :..:|......|:...:.:....|...:..|:..:|:|..|: ..:|||.::.
  Fly   202 RNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS-GEKVTLSISI 265

  Fly   286 MLTLVTMF--TGADIPPVA-YVKALDLWMAGCMLSVFAALAEFVVVKVLDVQYQ 336
            :::|...|  ....|||.: .|..|..::...|:.|..::.  |.|.||:|.::
  Fly   266 LISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISIC--VTVVVLNVHFR 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	65/314 (21%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	65/314 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	43/221 (19%)
		Cys-loop	136..150	CDD:349832	4/13 (31%)