DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12344 and Gabra5

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_058991.2	Gene:	Gabra5 / 29707	RGDID:	61859	Length:	464	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	126/454 - (27%)
Similarity:	209/454 - (46%)	Gaps:	45/454 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ISFGLGFILMWLSEA-TEAHMNYTAKPRVV--LPPNYVKEIRPP-SKKGSPVIVDFSIFVVDINS 71
            :|...||..|..|.. .|.:.|.|...|::  |...|...:||. .::.:.|..|  |:|.....
  Rat    24 LSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTD--IYVTSFGP 86

  Fly    72 INVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATL 136
            ::..:|::.:|:|..|.|.:.||.     |:.....:.|...:....|.||.:|.|.|    .::
  Rat    87 VSDTEMEYTIDVFFRQSWKDERLR-----FKGPMQRLPLNNLLASKIWTPDTFFHNGK----KSI 142

  Fly   137 THKFTS----VTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSD 197
            .|..|:    :.|..:.|:.|..|:.....|.|:.:.:|||...||:...|::..|.:|...|::
  Rat   143 AHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTN 207

  Fly   198 ----SGVTLNPELKLLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPS 257
                |.|......:|.||:| ||.:..|.    :....|.::.:|.:|..:|:||:.:|||:.|.
  Rat   208 GSTKSVVVAEDGSRLNQYHLMGQTVGTEN----ISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPC 268

  Fly   258 SLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFA 320
            .:.|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|...||:
  Rat   269 IMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFS 333

  Fly   321 ALAEFVVVKVLDVQ-YQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQT 384
            ||.||..|.....: :.:...:     .:..:.::|.:...:.:....|..:.|.|..|..|.:.
  Rat   334 ALIEFATVNYFTKRGWAWDGKK-----ALEAAKIKKKERELILNKSTNAFTTGKLTHPPNIPKEQ 393

  Fly   385 SLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWR---EIDKVSRAVFPILFFVFVLLYWPILL 445
            ...|.|.....|      |:..::..|...|..:.   :|||:||.||||||..|.|:||...|
  Rat   394 LPGGTGNAVGTA------SIRASEEKTSESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATYL 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	123/448 (27%)
Gabra5	NP_058991.2	LIC	15..450	CDD:273305	125/451 (28%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	51/212 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..414		8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820