Protein Alignment alka and Gabra2

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: XP_017454595.1
• Gene: Gabra2 / 289606
• RGDID: 61856
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 481
• Identity: 129/481 - (26%)
• Similarity: 212/481 - (44%)
• Gaps: 94/481 - (19%)

  Fly    13 FGLGFILMWLS--------EATEAHMNYTAKPRVV--LPPNYVKEIRPPSKKGSPVIVDF-SIFV 66
            |.|..:|:|..        :..||..|.|...|::  |...|...:||  ..|..:...| :|:|
  Rat    65 FPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRP--GLGDSITEVFTNIYV 127

  Fly    67 VDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSK-- 129
            .....::..||::.:|:|..|:|.:.||:     |:...:.:.|...:....|.||.:|.|.|
  Rat   128 TSFGPVSDTDMEYTIDVFFRQKWKDERLK-----FKGPMNILRLNNLMASKIWTPDTFFHNGKKS 187

  Fly   130 IAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLR 194
            :|...|:.:|.  :.:..:.|:.|..|:.....|.|..:.:|||...||:...|::....:|...
  Rat   188 VAHNMTMPNKL--LRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYI 250

  Fly   195 W----SDSGVTLNPE-LKLLQYN-LGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQT 253
            |    ||| |.:.|: .:|.||: |||.:..|.    :....|.::.:|.:|..:|:||:.:|||
  Rat   251 WTYNASDS-VQVAPDGSRLNQYDLLGQSIGKET----IKSSTGEYTVMTAHFHLKRKIGYFVIQT 310

  Fly   254 FAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCML 316
            :.|..:.|:||..||||..:::|.|....||.:||:.|:...|  .:|.|||..|:|.::|.|..
  Rat   311 YLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYA 375

  Fly   317 SVFAALAEFVVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRK-------- 373
            .||:||.||..|...                     .::|.     :|:|.:|.:.|
  Rat   376 FVFSALIEFATVNYF---------------------TKRGW-----AWDGKSVVNDKKKEKGSVM 414

  Fly   374 ----------ATQTPT---TPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVS 425
                      |...|.   .|..:::..:...|:|.::..........|...|.|     ||::|
  Rat   415 IQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSK-----IDRMS 474

  Fly   426 RAVFPILFFVFVLLYW-------PIL 444
            |.|||:||..|.|:||       |:|
  Rat   475 RIVFPVLFGTFNLVYWATYLNREPVL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	125/469 (27%)
Gabra2	XP_017454595.1	LIC	64..493	CDD:455710	127/472 (27%)
		LGIC_ECD_GABAAR_A2	100..302	CDD:349836	55/215 (26%)
		Cys-loop	219..233	CDD:349836	5/13 (38%)