Protein Alignment alka and GLRB

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 138/516 - (26%)
• Similarity: 235/516 - (45%)
• Gaps: 101/516 - (19%)

  Fly     7 TNAFISFGLGFILMWLSEATEAHMN----------------YTAKPRVVLPPN------------ 43
            |.||    |..|.:|:.||.....:                .:|:....:|.|
Human     6 TTAF----LILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVS 66

  Fly    44 YVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYV 108
            |...|| |:.||.||.|..:||:....||....||:||::|:.|:|.:.||::|.|.  .|.|.:
Human    67 YDPRIR-PNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDF--RGSDAL 128

  Fly   109 TLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMD 173
            |:.|.:::..|:||.:|.|.|.|....:|.:...:.::::..|..:.|:...::|.::..|:|||
Human   129 TVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMD 193

  Fly   174 IQVCPIYIESFSSNNQKVKLRWSDSGVTLNPELKLLQYNL-GQPLELEESDGYMPEKVGNFSRLT 237
            .|.|.:.:|||......::..|.........::.|.|::: .:.:|......|. :..|.::.:.
Human   194 TQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYY-KGTGYYTCVE 257

  Fly   238 VYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFT--GADIPP 300
            |.|...||:|.:::..:||:.|:|:|||.|||:..||...||.|.:..:|:|.:..|  .|::|.
Human   258 VIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPK 322

  Fly   301 VAYVKALDLWMAGCMLSVFAALAEFVVVKVL---DVQYQYQVNRIPKV----------------- 345
            |:||||||:|:..|:|..||:|.|:.||:|:   ..:.:.:..||.|.
Human   323 VSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVN 387

  Fly   346 ---LPMRISNMEKGQ--CATVASWEGGAVRSRKATQTPTTP---------------------GQT 384
               .|:.||.::.|:  |..|.:.:.. :||...:...:.|                     |::
Human   388 GTGTPVHISTLQVGETRCKKVCTSKSD-LRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKS 451

  Fly   385 SLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVLLYWPILL 445
            ..:.|..|| ||:              .|.....:.||..:||:||..|..|.::||.|.|
Human   452 QAKNNKKPP-PAK--------------PVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	133/509 (26%)
GLRB	NP_000815.1	LIC	43..496	CDD:455710	128/472 (27%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	50/188 (27%)
		Cys-loop	183..197	CDD:349811	6/13 (46%)