Protein Alignment CG12344 and GLRA2

DIOPT Version :9

• Sequence 1: NP_001286298.1
• Gene: CG12344 / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 148/441 - (33%)
• Similarity: 219/441 - (49%)
• Gaps: 73/441 - (16%)

  Fly    35 KPRVVLPPN------------YVKEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQ 87
            :|...|.|:            |...|| |:.||.||.|..:||:....|:....||:||::|:.|
Human    37 QPSQTLSPSDFLDKLMGRTSGYDARIR-PNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQ 100

  Fly    88 RWLESRL---EIPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNK 149
            :|.:|||   |.|||..:       |.|.:.::.|:||.:|.|.|.|....:|.....:.:.||.
Human   101 QWNDSRLAYSEYPDDSLD-------LDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNG 158

  Fly   150 TVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRW-SDSGVTLNPELKLLQYNL 213
            .|.|:.|:...::|.|:.:.:|||:|.|.:.:|||......:...| ||..|.:...|.|.|:.|
Human   159 KVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFIL 223

  Fly   214 GQPLELEESDGYMPE--KVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIP 276
            .:..||    ||..:  ..|.|:.:.|.|..|||:|::|||.:.||.|:|:|||.|||:.:||.|
Human   224 KEEKEL----GYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAP 284

  Fly   277 GRVTLLVTCMLTLVTMFTG--ADIPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQY---- 335
            .||.|.:|.:||:.|..:|  |.:|.|:||||:|:|||.|:|.|||||.|:..|..:..|:
Human   285 ARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFL 349

  Fly   336 -----QYQVNR---IPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQTSLQGNGGP 392
                 |.:.|:   :.:......|....|.|..|.  :|.||::..|...|.            |
Human   350 RLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVK--DGTAVKATPANPLPQ------------P 400

  Fly   393 PKPARRQSLLSVAWTDTDTGVEKIMWR--EIDKVSRAVFPILFFVFVLLYW 441
            ||             |.|...:|.:.|  .||.:|||.||:.|.:|.:.||
Human   401 PK-------------DGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYW 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	146/439 (33%)
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	145/432 (34%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3841
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860