Protein Alignment CG12344 and lgc-43

DIOPT Version :9

• Sequence 1: NP_001286298.1
• Gene: CG12344 / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_001023062.1
• Gene: lgc-43 / 259591
• WormBaseID: WBGene00008076
• Length: 679
• Species: Caenorhabditis elegans
• Alignment Length: 457
• Identity: 96/457 - (21%)
• Similarity: 177/457 - (38%)
• Gaps: 112/457 - (24%)

  Fly     1 MLDKFNTNAFISFGLGFILMWLSEATEAHMNYTAKPRVVLPPNYVKEIRPPSKKGSPVIVDFSIF 65
            ||::...|....:|..:||..|...                 :|.....|.:....||.|..:..
 Worm   304 MLEERRANEHRDYGSSYILPVLKSV-----------------DYDNTSVPLAFNDIPVNVAVAFN 351

  Fly    66 VVDINSINVEDMDFRVDMFIHQRWLESRL----EIPDDIFEEGDDYVTLLPEVFENFWQPDPYFL 126
            .:.:.:.:.|.|:|.:|:.:...|::.||    ..|..|.|:         .:.|..|:||||.:
 Worm   352 FLYLANFDSEMMEFSMDVEMEFSWIDIRLVNNYTKPIRIREK---------PIIEQIWRPDPYIV 407

  Fly   127 NSKIAEIATLTHKFTSVTLYKNKTVR--------YAARMHAIIACQMEFQLYPMDIQVCPIYIES 183
            |||        |.:.....:.|..:|        |..|:.::.:|.|.|.|||.|.|.|.:.|.|
 Worm   408 NSK--------HSYFHYVSFPNIRMRITPEGLVTYTVRVSSVCSCFMSFCLYPHDRQECDLRISS 464

  Fly   184 FSSNNQKVKLRWSDSGVTLNPELKLLQYNLGQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGH 248
            .:.:||.||..|..:.:....::.|.:.::   .:::.::.....|:.:.|.|.:.|..||....
 Worm   465 IAYSNQYVKFHWHSNPIKFQSKITLPELHI---TKIKTAECSTKGKLVDASCLRIIFSLERDSAR 526

  Fly   249 HLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGADIPPVAYVKALDLWMAG 313
            .:|:.:.||:|.:|.:|.:.::..:....|:...:|.:||||.|..|......:|:.::|:|
 Worm   527 FVIEKYVPSTLAMMFAWVAPYVPYNYEDVRIITPITVLLTLVQMEKGDKEIRTSYLTSIDVW--- 588

  Fly   314 CMLSVFAALAEFVVVKVLDVQYQYQVNRIPKVLPMRISNMEKG-----QCATVASWEGGAVRSRK 373
                 |||:..|.|:.:|:   ...|..:.|.......|.|:.     :|    ::|..|.|..:
 Worm   589 -----FAAMKSFTVLSLLE---SLAVLALIKRSRAMTKNAERAANEFERC----TFEAEAYRLNR 641

  Fly   374 ATQTPTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREIDKVSRAVFPILFFVFVL 438
                                                       ::..:|.:.|...|::|..|.:
 Worm   642 -------------------------------------------LYHRVDSICRFSSPVVFVAFFV 663

  Fly   439 LY 440
            .|
 Worm   664 YY 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	94/450 (21%)
lgc-43	NP_001023062.1	LGIC_ECD_anion	344..523	CDD:349788	48/198 (24%)
		LGIC_TM	527..665	CDD:365787	36/195 (18%)
		TM1 helix	527..551	CDD:349850	6/23 (26%)
		TM2 helix	555..577	CDD:349850	8/21 (38%)
		TM3 helix	583..609	CDD:349850	9/36 (25%)
		TM4 helix	610..665	CDD:349850	12/101 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910