Protein Alignment alka and GABRR2

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 111/414 - (26%)
• Similarity: 196/414 - (47%)
• Gaps: 41/414 - (9%)

  Fly    51 PSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTLLPEVF 115
            |:..|..:.|...:.|..::||:..||||.:.:::...|.:.||...    ...:..:|....:.
Human    70 PAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFS----SASNKSMTFDGRLV 130

  Fly   116 ENFWQPDPYFLNSKIAEIATLTHKFTS----VTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQV 176
            :..|.||.:|::||    .:.||..|:    :.::.:..|.|:.|:.....|.|:|..:|:|.|.
Human   131 KKIWVPDVFFVHSK----RSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQT 191

  Fly   177 CPIYIESFSSNNQKVKLRWSDSGVTLNPELK------LLQ-YNLGQPLELEESDGYMPEKVGNFS 234
            |.:.:||::..::.:.|.|.:...:|..:.|      |:| ::....|....|.|:       ::
Human   192 CSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGW-------YN 249

  Fly   235 RLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTG--AD 297
            ||.:.|...|.|...|:||:.|::|:|||||.|||:...|:|.||:|.:|.:||:.|:.||  |.
Human   250 RLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNAS 314

  Fly   298 IPPVAYVKALDLWMAGCMLSVFAALAEFVVVKVLDVQYQYQVNRIPKVLP-------MRISNMEK 355
            :|.|:||||:|:::....:.||.::.|:..|..|....:.:..::.:..|       .:...::.
Human   315 MPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLHSKTMMLDG 379

  Fly   356 GQCATVASWEGGAVRSRKATQTPTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIM-WR 419
            ....:.|:...|..||...|:...........|..|....||::.||.     ..||..... ..
Human   380 SYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLK-----GQTGFRIFQNTH 439

  Fly   420 EIDKVSRAVFPILFFVFVLLYWPI 443
            .|||.||.:||..:..|.|:||.:
Human   440 AIDKYSRLIFPASYIFFNLIYWSV 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	109/410 (27%)
GABRR2	NP_002034.3	LIC	51..464	CDD:455710	111/414 (27%)
		LGIC_ECD_GABAAR_rho	76..261	CDD:349806	46/199 (23%)
		Cys-loop	178..192	CDD:349806	6/13 (46%)