DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12344 and GABRG2

DIOPT Version :9

Sequence 1:	NP_001286298.1	Gene:	CG12344 / 36145	FlyBaseID:	FBgn0033558	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_944493.2	Gene:	GABRG2 / 2566	HGNCID:	4087	Length:	515	Species:	Homo sapiens

Alignment Length:	519	Identity:	126/519 - (24%)
Similarity:	216/519 - (41%)	Gaps:	105/519 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNTNAFISFGLGFILMWLS--------EATEAHMNYTAKPRVVLPP----------------NYV 45
            ::|..|......:||:.||        ::.:.:.:|.:....||.|                .|.
Human    14 YSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYD 78

  Fly    46 KEIRPPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLEIPDDIFEEGDDYVTL 110
            .::||.... .|.::...::|..|..:|..:|::.:|:|..|.|.:.||:     |......:.|
Human    79 NKLRPDIGV-KPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLK-----FNSTIKVLRL 137

  Fly   111 LPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQ 175
            ...:....|.||.:|.|||.|:...:|.....:.::.:..|.|..|:.....||::...:|||..
Human   138 NSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEH 202

  Fly   176 VCPIYIESFSSNNQKVKLRWSDSGVTLNPELKLLQYNLGQPLELEE-----SDGYMPEKV----- 230
            .||:   .|||.::.:......||| ::....|..:....|..|..     ||||..|::
Human   203 SCPL---EFSSWSRSIAQAGMCSGV-ISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWK 263

  Fly   231 ---------------------------------GNFSRLTVYFRFERQIGHHLIQTFAPSSLVVM 262
                                             |::..::|||...|::|:..|||:.|.:|:|:
Human   264 RSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVV 328

  Fly   263 LSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAALAEF 325
            |||.|||:..||:|.|.:|.:|.:||:.|:.|.|  .:|.|:||.|:||:::.|.:.||:||.|:
Human   329 LSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEY 393

  Fly   326 VVVKVLDVQYQYQVNRIPKVLPMRISNMEKGQCATVASWEGGAVRSRKATQTPTTPGQTSLQGN- 389
            ..:      :.:..||.|.   ......:|.....:.|::...:..|..:.|......|.||..
Human   394 GTL------HYFVSNRKPS---KDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERD 449

  Fly   390 ---GGPPKPARRQSLLSVAWTDTDTGVEKIMWR---------EIDKVSRAVFPILFFVFVLLYW 441
               |......:..:.....:.|..||.    ||         ::|..:|..||..|.:|.|:||
Human   450 EEYGYECLDGKDCASFFCCFEDCRTGA----WRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYW 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	123/514 (24%)
GABRG2	NP_944493.2	LIC	69..512	CDD:273305	116/464 (25%)
		Neur_chan_LBD	69..312	CDD:280998	54/252 (21%)
		Neur_chan_memb	319..509	CDD:280999	57/202 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820