Protein Alignment CG12344 and GABRB3

DIOPT Version :9

• Sequence 1: NP_001286298.1
• Gene: CG12344 / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_000805.1
• Gene: GABRB3 / 2562
• HGNCID: 4083
• Length: 473
• Species: Homo sapiens
• Alignment Length: 454
• Identity: 131/454 - (28%)
• Similarity: 212/454 - (46%)
• Gaps: 75/454 - (16%)

  Fly    43 NYVKE----------IR-PPSKKGSPVIVDFSIFVVDINSINVEDMDFRVDMFIHQRWLESRLE- 95
            ::|||          || .|...|.||.|..:|.:..|:.::..:||:.:.|:..|.|.:.||.
Human    35 SFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY 99

  Fly    96 --IPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTHKFTSVTLYKNKTVRYAARMH 158
              ||.::        ||...|.:..|.||.||||.|.:.:..:|.|...:.|:.:.||.|..|:.
Human   100 SGIPLNL--------TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156

  Fly   159 AIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRW--SDSGVTLNPELKLLQYNLGQPLELEE 221
            ...||.|:.:.||:|.|.|.:.|||:......::..|  .|..||....::|.|:::.:...:..
Human   157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSR 221

  Fly   222 SDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSSLVVMLSWFSFWLGLDAIPGRVTLLVTCM 286
            :..:   ..|.:.||::.||.:|.||:.::||:.||.|:.:|||.|||:..||...||.|.:|.:
Human   222 NVVF---ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTV 283

  Fly   287 LTLVTMFT--GADIPPVAYVKALDLWMAGCMLSVFAALAEFVVV--------------------K 329
            ||:.|:.|  ...:|.:.||||:|:::.||.:.||.||.|:..|                    |
Human   284 LTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAK 348

  Fly   330 VLDVQYQYQVNRIPKVLPMRISNMEK-----------GQCATVA-SWEGGAVRSRKATQTPTTPG 382
            ..:.:.:.:.||:.....:.::::|.           |.....| |::...::.||  |:....|
Human   349 AKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRK--QSMPREG 411

  Fly   383 QTSLQGNGGPPKP----ARRQSLLSVAWTD-TDTGVEKIMWREIDKVSRAVFPILFFVFVLLYW 441
            .....|:...|..    .||.|.|.:...| ||...       ||:.||.|||..|.:|.|:||
Human   412 HGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNA-------IDRWSRIVFPFTFSLFNLVYW 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	129/452 (29%)
GABRB3	NP_000805.1	LIC	10..471	CDD:273305	131/454 (29%)
		Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990	120..122		1/1 (100%)
		Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990, ECO:0007744|PDB:4COF	180..182		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810