Protein Alignment CG12344 and GABRB1

DIOPT Version :9

• Sequence 1: NP_001286298.1
• Gene: CG12344 / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_000803.2
• Gene: GABRB1 / 2560
• HGNCID: 4081
• Length: 474
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 140/486 - (28%)
• Similarity: 232/486 - (47%)
• Gaps: 84/486 - (17%)

  Fly    11 ISFGLGFILMWLSEATE--AHMNYTAKPRVVLPPNYVKEIRPPSKKGSPVIVDFSIFVVDINSIN 73
            :||.:...::..:.:|.  ::|:|..:....|...|...:| |...|.||.|...|.|..|:.::
Human    13 LSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLR-PDFGGPPVDVGMRIDVASIDMVS 76

  Fly    74 VEDMDFRVDMFIHQRWLESRLE---IPDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIAT 135
            ..:||:.:.|:..|.|.:.||.   ||.::        ||...|.:..|.||.||||.|.:.:..
Human    77 EVNMDYTLTMYFQQSWKDKRLSYSGIPLNL--------TLDNRVADQLWVPDTYFLNDKKSFVHG 133

  Fly   136 LTHKFTSVTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWS--DS 198
            :|.|...:.|:.:.||.|..|:....||.|:.:.||:|.|.|.:.|||:......::..|:  :.
Human   134 VTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEG 198

  Fly   199 GVT-LN----PELKLLQYNLGQPLELEESDGYMPEKV----GNFSRLTVYFRFERQIGHHLIQTF 254
            .|| :|    |:..::.|.:            :.:||    |.:.||::.||.:|.||:.::||:
Human   199 AVTGVNKIELPQFSIVDYKM------------VSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTY 251

  Fly   255 APSSLVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFT--GADIPPVAYVKALDLWMAGCMLS 317
            .||:|:.:|||.|||:..||...||.|.:|.:||:.|:.|  ...:|.:.||||:|:::.||.:.
Human   252 MPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVF 316

  Fly   318 VFAALAEFVVVKVL------------------DVQYQYQVNRIP-----KVL--PMRISNMEKGQ 357
            ||.||.|:..|..:                  :.:.:.::|::.     .:|  .:.|.|...|.
Human   317 VFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGS 381

  Fly   358 ---------CATVASWEGGAVRSRKATQTPTTPGQTSLQGNGGPPKP--ARRQSLLSVAWTD-TD 410
                     .||:.|::..:::.||...:....|: :|..:|.|.|.  .||.|.|.|...| ||
Human   382 EVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-ALDRHGVPSKGRIRRRASQLKVKIPDLTD 445

  Fly   411 TGVEKIMWREIDKVSRAVFPILFFVFVLLYW 441
            .       ..|||.||..|||.|.:|.::||
Human   446 V-------NSIDKWSRMFFPITFSLFNVVYW 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12344	NP_001286298.1	LIC	8..441	CDD:273305	138/484 (29%)
GABRB1	NP_000803.2	LIC	9..472	CDD:273305	140/486 (29%)
		Agonist binding. /evidence=ECO:0000250	120..122		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250	180..182		1/1 (100%)
		Allosteric effector binding. /evidence=ECO:0000250	290..311		7/20 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810