Protein Alignment alka and GABRA6

DIOPT Version :10

• Sequence 1: NP_610619.2
• Gene: alka / 36145
• FlyBaseID: FBgn0033558
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 129/483 - (26%)
• Similarity: 210/483 - (43%)
• Gaps: 98/483 - (20%)

  Fly    18 ILMWLSEA---TEAHMNYTAK--PRVV--LPPNYVKEIRPPSKKGSPVIVDFSIFVVDINSINVE 75
            |::||..|   .|...|:.::  .|::  |...|...:| |...|:...|...|:|.....::..
Human    10 IILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLR-PGFGGAVTEVKTDIYVTSFGPVSDV 73

  Fly    76 DMDFRVDMFIHQRWLESRLEI--PDDIFEEGDDYVTLLPEVFENFWQPDPYFLNSKIAEIATLTH 138
            :|::.:|:|..|.|.:.||:.  |.:|       ::|...:....|.||.:|.|.|    .::.|
Human    74 EMEYTMDVFFRQTWTDERLKFGGPTEI-------LSLNNLMVSKIWTPDTFFRNGK----KSIAH 127

  Fly   139 KFTS----VTLYKNKTVRYAARMHAIIACQMEFQLYPMDIQVCPIYIESFSSNNQKVKLRWSDSG 199
            ..|:    ..:.:|.|:.|..|:.....|.|....:|||...||:...|::....::...|. .|
Human   128 NMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWK-KG 191

  Fly   200 VTLNPEL-----KLLQYNL-GQPLELEESDGYMPEKVGNFSRLTVYFRFERQIGHHLIQTFAPSS 258
            ...:.|:     .||||:| ||.:..|.    :....|.:..:||||..:|::|:.:||.:.|..
Human   192 PLYSVEVPEESSSLLQYDLIGQTVSSET----IKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCI 252

  Fly   259 LVVMLSWFSFWLGLDAIPGRVTLLVTCMLTLVTMFTGA--DIPPVAYVKALDLWMAGCMLSVFAA 321
            :.|:||..|||:..:::|.|....:|.:||:.|:...|  .:|.|:|..|:|.::|.|...||:|
Human   253 MTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSA 317

  Fly   322 LAEFVVVKVL-DVQYQ-----YQVNRIPKV----------------------LPMRISNMEKGQC 358
            |.||..|... ::|.|     .|....|.|                      |..||:::   ..
Human   318 LIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSL---SL 379

  Fly   359 ATVASWEGGAVRSRK--ATQTPTTPGQTSLQGNGGPPKPARRQSLLSVAWTDTDTGVEKIMWREI 421
            ..|:|.|...|.:|.  ...||.||          ||        ||.|:..|.         :|
Human   380 PIVSSSEANKVLTRAPILQSTPVTP----------PP--------LSPAFGGTS---------KI 417

  Fly   422 DKVSRAVFPILFFVFVLLYWPILLMKSS 449
            |:.||.:||:.|..|.|:||.:.|.|.:
Human   418 DQYSRILFPVAFAGFNLVYWVVYLSKDT 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alka	NP_610619.2	LIC	8..441	CDD:455710	125/473 (26%)
GABRA6	NP_000802.2	LIC	5..440	CDD:455710	127/476 (27%)
		LGIC_ECD_GABAAR_A6	42..239	CDD:349840	53/213 (25%)
		Cys-loop	156..170	CDD:349840	5/13 (38%)